Allylamine and Allyl Alcohol Plasma Copolymerization: Synthesis of Customizable Biologically‐Reactive Three‐Dimensional Scaffolds

Hawker, Morgan J.; Pegalajar‐Jurado, Adoracion; Hicks, Kiah I.; Shearer, Jeffrey C.; Fisher, Ellen R.

doi:10.1002/ppap.201500098

Cited by 8 publications

(7 citation statements)

References 58 publications

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“…Thus, plasma polymers do not have much in common with conventional counterparts. In the case of plasma polymers prepared from mixtures of precursors, chemical functionalities of different monomers become homogeneously and randomly mixed in a single phase, and no phase separation is typically observed. − …”

Section: Introductionmentioning

confidence: 99%

Microphase-Separated PE/PEO Thin Films Prepared by Plasma-Assisted Vapor Phase Deposition

Choukourov

Gordeev

Ponti

et al. 2016

ACS Appl. Mater. Interfaces

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Immiscible polymer blends tend to undergo phase separation with the formation of nanoscale architecture which can be used in a variety of applications. Different wet-chemistry techniques already exist to fix the resultant polymeric structure in predictable manner. In this work, an all-dry and plasma-based strategy is proposed to fabricate thin films of microphase-separated polyolefin/polyether blends. This is achieved by directing (-CH2-)100 and (-CH2-CH2-O-)25 oligomer fluxes produced by vacuum thermal decomposition of poly(ethylene) and poly(ethylene oxide) onto silicon substrates through the zone of the glow discharge. The strategy enables mixing of thermodynamically incompatible macromolecules at the molecular level, whereas electron-impact-initiated radicals serve as cross-linkers to arrest the subsequent phase separation at the nanoscale. The mechanism of the phase separation as well as the morphology of the films is found to depend on the ratio between the oligomeric fluxes. For polyolefin-rich mixtures, polyether molecules self-organize by nucleation and growth into spherical domains with average height of 22 nm and average diameter of 170 nm. For equinumerous fluxes and for mixtures with the prevalence of polyethers, spinodal decomposition is detected that results in the formation of bicontinuous structures with the characteristic domain size and spacing ranging between 5 × 10(1) -7 × 10(1) nm and 3 × 10(2)-4 × 10(2) nm, respectively. The method is shown to produce films with tunable wettability and biologically nonfouling properties.

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Section: Introductionmentioning

confidence: 99%

Microphase-Separated PE/PEO Thin Films Prepared by Plasma-Assisted Vapor Phase Deposition

Choukourov

Gordeev

Ponti

et al. 2016

ACS Appl. Mater. Interfaces

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“…Notably, it can be challenging to measure WCA values on polymer substrates that are porous, especially those that are hydrophilic (either inherently or following plasma modification to enhance hydrophilicity. For these types of materials, it is often more useful to measure differences in water absorption behavior prior to and following plasma treatment . Methods to evaluate the surface wettability of plasma-modified polymer substrates with complex architectures has been reviewed elsewhere …”

Section: Characterizing Plasma-modified Polymer Surfacesmentioning

confidence: 99%

“…For these types of materials, it is often more useful to measure differences in water absorption behavior prior to and following plasma treatment. 68 Methods to evaluate the surface wettability of plasma-modified polymer substrates with complex architectures has been reviewed elsewhere. 69 Multiple probe liquids with different surface tensions can be used to estimate changes in polymer surface energy following plasma modification.…”

Section: Characterizing Plasma-modified Polymer Surfacesmentioning

confidence: 99%

Utilizing Radio Frequency Plasma Treatment to Modify Polymeric Materials for Biomedical Applications

Morelli

Hawker

2021

ACS Biomater. Sci. Eng.

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Studies that utilize radio frequency plasma modification as a strategy to tune the surface properties of polymeric constructs with the goal of enhancing their use as biomedical devices have grown considerably in number over the past decade. In this Review, we present the importance of plasma surface treatment to biomedical applications, including tissue engineering and wound healing. First, we introduce several key polymeric materials of interest for use as biomaterials, including those that are naturally derived and synthetic. We, then, provide an overview of possible outcomes of plasma modification, such as surface activation, etching, and deposition of a thin film, all of which can be used to alter the surface properties of a given polymer. Following this discussion, we review the methods used to characterize plasma-treated polymer surface properties, as well as the techniques used to evaluate their interactions with biological species of interest such as mammalian cells, bacteria, and blood components. To close, we provide a perspective on future outlooks of this exciting and rapidly evolving field.

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“…Plasma modified surfaces from different monomers including those having amino groups such as pyrrole, allylamine, propylamine and cyclopropylamine have been used as substrates to study the interaction of cells with materials (Tserepi et al, 2016, Boespflug et al, 2016, Manakhov et al, 2016, Klages et al, 2013. Sterile, plasmatreated samples can be used directly in live animals or for cell culture, and they are stable even after several cycles of sterilization and different substrates can be coated (Maslakcia et al, 2017, Hawker et al, 2015, Cheng et al, 2013. It may be interesting to refer that Zhang (2005) and Chen et al, (2004) * Addresss correspondence to: Elizabeth PÉREZ-TEJADA, npereztejada@ipn.mx have studied DNA hybridization on plasma-polymerized allylamine films.…”

Section: Biocellmentioning

confidence: 99%

Effect of synthesis variables of plasma synthesized polymers on growth of HepG2 cells

Perez-Tejada¹,

Morales-Corona²,

Gomez-Quiroz³

et al. 2018

Biocell

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Low pressure plasma polymer films were synthesized using pyrrole and allylamine monomers and adding iodine was used (or not) for the reaction in both cases. They were polymerized on glass substrates under the same reaction conditions. Polymerization of allylamine was also studied at different operating powers. These thin polymer films were used as culture surfaces for HepG2 cells, a cell line derived from a human hepatoma. The proliferation, differentiation and two-dimensional propagation until obtaining monolayer of the cells was studied on the different synthetized films and correlations were established between the conditions of synthesis, the physicochemical characteristics obtained and the performance as substrates for the cellular growth.

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Allylamine and Allyl Alcohol Plasma Copolymerization: Synthesis of Customizable Biologically‐Reactive Three‐Dimensional Scaffolds

Cited by 8 publications

References 58 publications

Microphase-Separated PE/PEO Thin Films Prepared by Plasma-Assisted Vapor Phase Deposition

Microphase-Separated PE/PEO Thin Films Prepared by Plasma-Assisted Vapor Phase Deposition

Utilizing Radio Frequency Plasma Treatment to Modify Polymeric Materials for Biomedical Applications

Effect of synthesis variables of plasma synthesized polymers on growth of HepG2 cells

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