Allylation of Aryl Grignard Reagents in the Presence of Transition Metal Catalysis and Organic Catalysis

Abstract

The allylation yield and regioselectivity of phenyl Grignard reagent in THF was investigated in the presence of complexed transition metals and also uncomplexed or complexed transition metal salts. Additionally, the effect of Lewis acids and Lewis bases on the yield and the regioselectivity of the allylic arylation was also observed. Neither P-containing ligands for transition metal complexes, nor transition metal salts did make a difference on the yield and : product ratio and gave the is -product as the main product. However, donor cosolvents resulted in decrease in the yield and change of the regioselectivity.