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Nuzhdin, Sergey V.; Reiwitch, Sarah G

doi:10.1023/a:1016335504009

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…However, when studying individual QTLs associated with lifespan, conflicting results have been obtained. For example, some authors have observed QTL effects associated with sex [164,166,168,173,189,211], including in lines selected for late fecundity and increased lifespan ("O" lines) [171], while other authors have noted the absence of such effects; that is, QTLs affected lifespan in males and females equally [184,186,187]. Furthermore, many of the detected sex-specific QTLs could be a consequence of errors in statistical analysis [212] or a result of keeping males and females separate.…”

Section: Sexual Dimorphism and Lifespan Controlmentioning

confidence: 99%

Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm

Bylino,

Ogienko,

Batin

et al. 2024

IJMS

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Lifespan is a complex quantitative trait involving genetic and non-genetic factors as well as the peculiarities of ontogenesis. As with all quantitative traits, lifespan shows considerable variation within populations and between individuals. Drosophila, a favourite object of geneticists, has greatly advanced our understanding of how different forms of variability affect lifespan. This review considers the role of heritable genetic variability, phenotypic plasticity and stochastic variability in controlling lifespan in Drosophila melanogaster. We discuss the major historical milestones in the development of the genetic approach to study lifespan, the breeding of long-lived lines, advances in lifespan QTL mapping, the environmental factors that have the greatest influence on lifespan in laboratory maintained flies, and the mechanisms, by which individual development affects longevity. The interplay between approaches to study ageing and lifespan limitation will also be discussed. Particular attention will be paid to the interaction of different types of variability in the control of lifespan.

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Section: Sexual Dimorphism and Lifespan Controlmentioning

confidence: 99%

Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm

Bylino,

Ogienko,

Batin

et al. 2024

IJMS

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“…Charlesworth & Willis, 2009) acting on TL. For instance, the observed fitness benefits of outcrossing inbred populations (Frankham, 2015) could be reflected in TL restoration (Nuzhdin & Reiwitch, 2002;Ozawa et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Inbreeding is associated with shorter early-life telomere length in a wild passerine

Pepke

Niskanen

Kvalnes

et al. 2021

Preprint

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Inbreeding can have negative effects on survival and reproduction, which may be of conservation concern in small and isolated populations. However, the physiological mechanisms underlying inbreeding depression are not well-known. The length of telomeres, the DNA sequences protecting chromosome ends, has been associated with health or fitness in several species. We investigated effects of inbreeding on early-life telomere length in two small island populations of wild house sparrows (Passer domesticus) known to be affected by inbreeding depression. Using genomic and pedigree-based measures of inbreeding we found that inbred nestling house sparrows have shorter telomeres. This negative effect of inbreeding on telomere length may have been complemented by a heterosis effect resulting in longer telomeres in individuals that were less inbred than the population average. Furthermore, we found some evidence of stronger effects of inbreeding on telomere length in males than females. Thus, telomere length may reveal subtle costs of inbreeding in the wild and demonstrate a route by which inbreeding negatively impacts the physiological state of an organism already at early life-history stages.

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Inbreeding is associated with shorter early-life telomere length in a wild passerine

et al. 2022

View full text Add to dashboard Cite

Inbreeding can have negative effects on survival and reproduction, which may be of conservation concern in small and isolated populations. However, the physiological mechanisms underlying inbreeding depression are not well-known. The length of telomeres, the DNA sequences protecting chromosome ends, has been associated with health or fitness in several species. We investigated effects of inbreeding on early-life telomere length in two small island populations of wild house sparrows (Passer domesticus) known to be affected by inbreeding depression. Using genomic measures of inbreeding we found that inbred nestling house sparrows (n = 371) have significantly shorter telomeres. Using pedigree-based estimates of inbreeding we found a tendency for inbred nestling house sparrows to have shorter telomeres (n = 1195). This negative effect of inbreeding on telomere length may have been complemented by a heterosis effect resulting in longer telomeres in individuals that were less inbred than the population average. Furthermore, we found some evidence of stronger effects of inbreeding on telomere length in males than females. Thus, telomere length may reveal subtle costs of inbreeding in the wild and demonstrate a route by which inbreeding negatively impacts the physiological state of an organism already at early life-history stages.

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Untitled

Cited by 4 publications

References 20 publications

Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm

Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm

Inbreeding is associated with shorter early-life telomere length in a wild passerine

Inbreeding is associated with shorter early-life telomere length in a wild passerine

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