In recent years, much effort has been expended to developing miniaturized, reliable sensors for measuring physical and chemical liquid properties. Microacoustic devices may be employed to determinate physical quantities perturbing the propagation conditions of the acoustic wave, even in liquid environments. For liquid sensors, acoustic modes with shear polarization are often used in order to avoid radiation losses. Examples are shear bulk modes, surface skimming bulk waves, shear-horizontal acoustic plate modes, and Love modes. Furthermore, modes with sagittal polarization may be applied if their phase velocity is sufficiently lower than the sound velocity in the adjacent liquid. General interactions between acoustic waves and liquids are viscous coupling, acoustoelectric effects, and mass loading. The resulting changes in device frequency and attenuation may be utilized for sensing purposes.The general advantages of microacoustic sensors are high sensitivity, simple fabrication, and quasidigital frequency readout. Hence, a wide variety of devices based on different modes for very different applications has been discussed in the relevant literature. The aim of this review is to provide a systematic overview of microacoustic sensors particularlay suited for operation in liquids.First, we provide a brief introductionto surfaceacousticwave devices and the underlying physics, basic microacoustic structures, and general measurement techniques. A description of the mechanisms of interaction between liquids and acoustic waves is then followed by a comprehensive survey covering the different types of microacoustic liquid sensors, with emphasis on the mode-specific device properties. Thereafter, aspects of material selection and device fabrication are summarized. Lastly, an overview is given indicating where microacoustic liquid sensors have already been put into practice and where their application may be expected in the near future.