Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Haghani, Fatemeh; Arabnezhad, Mohammad-Reza; Mohammadi, Salman; Ghaffarian-Bahraman, Ali

doi:10.1007/s43450-022-00231-3

Cited by 45 publications

(24 citation statements)

References 142 publications

(184 reference statements)

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“…Moreover, the application of Aloe gel and/or olive oil reduced the expression of nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) and increased the cell proliferation and angiogenesis markers in the healing wound. Agreeing, that the beneficial effects of A. vera in streptozotocin‐induced diabetic rats were recently reviewed by Haghani et al [39] …”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the application of Aloe gel and/or olive oil reduced the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) and increased the cell proliferation and angiogenesis markers in the healing wound. Agreeing, that the beneficial effects of A. vera in streptozotocininduced diabetic rats were recently reviewed by Haghani et al [39] To date, most studies about its wound-healing effects are based on the A. vera gel and latex. Innovatively, Razia and collaborators [40] showed for the first time the synergistic effect of the A. vera flower and Aloe gel on cutaneous wound healing, revealing its molecular mechanism targeting microfibril-associated glycoprotein 4 (MFAP4) and its associated signaling pathway.…”

Section: Aloe Vera (L) Burmfmentioning

confidence: 99%

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Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Pereira

Cury

Nunes

et al. 2023

Chemistry & Biodiversity

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In southern Brazil, the biodiversity is great and the traditional use of medicinal plants for wound healing has been documented in ethnobotanical studies and pharmacological studies have assessed their wound properties and phytochemistry. Therefore, this study evaluated ethnobotanical surveys regarding medicinal plants used in southern Brazil for wound healing and studies about the healing properties of these plants published between 2000 and 2022. To retrieve articles related to the study, Web of Science, PubMed (NLM), Open Access Journals, Scielo, Lilacs, and Google Scholar, with keywords including medicinal plants, wound healing, and South of Brazil, have been used. As a result, 73 medicinal plants belonging to 39 families were found in ethnobotanical surveys as a traditional resource used for wound healing in southern Brazil, 15 of which were cited more than once. Besides, 14 of these 15 plants were also used as healing agents worldwide. The most cited plant with healing actions in southern Brazil was Symphytum officinale L. (comfrey). From 2000 to date, 44 articles scientifically demonstrated the wound‐healing effects of the southern Brazilian plants found in ethnobotanical surveys reviewed. The folk medicine of southern Brazil presents a variety of medicinal plants for wound‐healing purposes, and scientific data were found for some of those plants. However, the wound‐healing properties of many plants have yet to be investigated, and the current literature still needs more phytochemical information about the plants studied. Aside from this, the future focus should be on the standardization of herbal extracts, and further research is required to investigate the pharmacological mechanisms. Clinical research in this area remains in its infancy and warrants more robust further clinical studies.

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Section: Resultsmentioning

confidence: 99%

Section: Aloe Vera (L) Burmfmentioning

confidence: 99%

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Pereira

Cury

Nunes

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…In Iranian medicine, aloe is applied as an anti-fever, anti-infection, and wound healing reagent ( Dey et al, 2017 ). Nowadays, this medicinal plant is frequently used in the field of cosmetology ( Haghani et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

The current status of old traditional medicine introduced from Persia to China

Shi

Yang²,

Zhou³

et al. 2022

Front. Pharmacol.

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Traditional Chinese medicine (TCM) includes over ten thousand herbal medicines, some of which were introduced from outside countries and territories. The Silk Road enabled the exchange of merchandise such as teas, silks, carpets, and medicines between the East and West of the Eurasia continent. During this time, the ‘Compendium of Materia Medica’ (CMM) was composed by a traditional medicine practitioner, Shizhen Li (1,518–1,593) of the Ming Dynasty. This epoch-making masterpiece collected knowledge of traditional medical materials and treatments in China from the 16th century and before in utmost detail, including the origin where a material was obtained. Of 1892 medical materials from the CMM, 46 came from Persia (now Iran). In this study, the basic information of these 46 materials, including the time of introduction, the medicinal value in TCM theory, together with the current status of these medicines in China and Iran, are summarized. It is found that 20 herbs and four stones out of the 46 materials are registered as medicinal materials in the latest China Pharmacopoeia. Now most of these herbs and stones are distributed in China or replacements are available but saffron, ferula, myrrh, and olibanum are still highly dependent on imports. This study may contribute to the further development, exchange, and internationalization of traditional medicine of various backgrounds in the world, given the barriers of transportation and language are largely eased in nowadays.

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“…The antidiabetic effect of Aloe vera (L.) Burm.f. has been extensively reviewed ( Radha and Laxmipriya, 2015 ; Suksomboon et al, 2016 ; Haghani et al, 2022 ). A systematic review of the evaluation of biological properties and clinical effectiveness of Aloe vera (L.) Burm.f.…”

Section: Medicinal Plants In Zimbabwe With Antidiabetic Propertiesmentioning

confidence: 99%

Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review

2022

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Use of medicinal plants and herbs in the treatment and management of diseases, including diabetes mellitus and its complications remains an integral part of African tradition. In Zimbabwe, nearly one million people are living with diabetes mellitus. The prevalence of diabetes mellitus in Zimbabwe is increasing every year due to lifestyle changes, and has accelerated the use of traditional medicines for its treatment and management in urban areas. In addition, the high cost of modern medicine has led many people in rural parts of Zimbabwe to rely on herbal plant medicine for the treatment of diabetes mellitus and its complications. This review highlights a number of studies carried out to evaluate the antidiabetic properties of indigenous plants found in Zimbabwe with the goal of treating diabetes mellitus. Further, we discuss the mechanism of action of various plant extracts in the treatment and management of diabetes mellitus. Together, this review article can open pathways leading to discovery of new plant derived medicines and regularization of use of crude plant remedies to treat diabetes mellitus by the Zimbabwean government and others across Africa.

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Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Cited by 45 publications

References 142 publications

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

The current status of old traditional medicine introduced from Persia to China

Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review

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