Aloe Vera Ethanol Extract as a Therapy for Alveolar Mandible Regeneration in Lipopolysaccharide-Exposed Rats

Abstract

Objective:The study examined the effects of Aloe vera ethanol extract on alveolar mandible regeneration in rats (Rattus norvegicus).Methods: Rats were divided into five groups as follows: Negative control group received no treatment, positive control group received Escherichia coli lipopolysaccharide (LPS) alone for 5 days, and Groups P1, P2, and P3 received LPS for 5 days followed by 40, 80, and 160 mg/kg BW A. vera ethanol extract, respectively, orally on days 6-12. Alveolar bone tissues were taken and histologically processed through hematoxylin-eosin staining. Osteoblast and osteoclast numbers in alveolar tissue were also examined. Results:One-way ANOVA revealed strong relationships between the A. vera ethanol extract dosage and the numbers of osteoblasts (r=0.921, p<0.05) and osteoclasts (r=−0.631, p<0.05) in rats. Conclusion:A. vera ethanol extract appears capable of stimulating alveolar bone regeneration following LPS exposure.

Effects of Centella Asiatica (L.) Leaf Extract on Bone Calcium and Phosphate Levels of Ovariectomized Rats

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Effect of Centella Asiatica L. On the Number of Osteoclasts, Osteoblasts, and Osteocytes in the Tibiae of Ovariectomized Rats

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