Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial

Sahebnasagh, Adeleh; Saghafi, Fatemeh; Ghasemi, Arash; Âkbari, Jafar; Alipour, Abbas; Habtemariam, Solomon; Safdari, Mohammadreza; Ghaleno, Hassan Rezai; Salehifar, Ebrahim

doi:10.1007/s12029-021-00597-y

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Dispõe-se, ainda, de estudos que ratificam que a babosa pode ser utilizada em outros efeitos colaterais associados a radioterapia, como a redução da incidência de proctite aguda e mucosite induzida por radiação 16 . Além disso, outras pesquisas demonstram o benefício do Aloe vera em relação as radiodermatites com a redução de casos moderados a graves de eritemas e de descamação úmida 17 .…”

Section: Discussionunclassified

Aloe Vera Como Estratégia De Cuidado De Enfermagem Para Tratamento De Pessoas Com Radiodermatites

De Oliveira,

Louise de Souza Fernandes Bezerra,

Carneiro de Azevedo Fernandes

et al. 2023

Nursing (São Paulo)

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Objetivo: descrever como acontece a utilização de Aloe vera como estratégia de cuidado de enfermagem para o tratamento de pessoas com radiodermatites. Metodologia: caráter retrospectivo e descritivo com a técnica da entrevista semiestruturada com as enfermeiras prescritoras de Aloe. Resultados: estruturação de conhecimentos sobre o Aloe vera como conduta de enfermagem nas radiodermatites que no Hospital Solidariedade resulta na efetiva prevenção de radiodermatites, principalmente de suas formas mais graves. Salienta-se que a babosa consegue prevenir a radiodermatite através do aumento da oxigenação da lesão e da diminuição da quantidade local de tecidos mortos. O estudo, também, proporciona uma maior compreensão sobre a função do enfermeiro na radioterapia e na reabilitação da pele. Conclusão: o Aloe vera tem um papel determinante na prevenção das radiodermatites, sendo um agente terapêutico inovador na área da enfermagem dermatológica e oncológica. DESCRITORES: Aloe vera; Cuidados de enfermagem; Radiodermatite.

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Section: Discussionunclassified

Aloe Vera Como Estratégia De Cuidado De Enfermagem Para Tratamento De Pessoas Com Radiodermatites

De Oliveira,

Louise de Souza Fernandes Bezerra,

Carneiro de Azevedo Fernandes

et al. 2023

Nursing (São Paulo)

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“…Previously, compounds with similar anti-inflammatory and antioxidant properties have been used successfully for this complication. For instance, the anti-inflammatory and antioxidant activity of herbal products has been demonstrated in different experimental and clinical evidences [3,20,40]. Rafati et al demonstrated that the topical administration of Nigella sativa 5% gel with anti-inflammatory and antioxidant properties delayed and decreased the severity of ARD and its related symptoms compared to the placebo (3).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies evaluated the effect of various topical formulations in RID, such as aloe vera, anionic phospholipids and hyaluronic acid based formulation, and corticosteroids [16][17][18][19][20]. However, until now, there is no standard measure for prevention of RID in patients with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Effects of topical timolol for the prevention of radiation-induced dermatitis in breast cancer: a pilot triple-blind, placebo-controlled trial

et al. 2022

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Introduction Radiation therapy is one of the standard methods in the treatment of breast cancer. Radiotherapy-induced dermatitis (RID) is a common complication of radiotherapy (RT) resulting in less tolerance in RT and even discontinuation of treatment. Timolol is a β-adrenergic receptor antagonist that presents the best wound healing effects on both chronic and incurable wound healing. Topical forms of timolol could be effective in the prevention of RID due to the role of β-adrenergic receptors in skin cells and keratinocyte migration, as well as the anti-inflammatory effect of timolol. However, no placebo-controlled randomized trial is available to confirm its role. The current trial aimed to evaluate the efficacy of topical timolol 0.5% (w/w) on the RID severity and patients' quality of life (QOL). Method Patients aged older than 18 years with positive histology confirmed the diagnosis of invasive and localized breast cancer were included. Patients were randomized based on the random number table to receive each of the interventions of timolol 0.5% (w/w) or placebo topical gels from the first day of initiation of RT and for 6 weeks, a thin layer of gel twice daily. Patients were asked to use a thin layer of gel for at least two hours before and after radiation therapy. Primary outcomes were acute radiation dermatitis (ARD) grade using Radiation Therapy Oncology Group and the European Organization for Research and Treatment of Cancer (RTOG/EORTC) scale and severity of desquamation based on Common Terminology Criteria for Adverse Events (CTCAE), version 5.0. Secondary outcomes were QOL based on Skindex16 (SD-16), maximum grade of ARD, and time of initial RD occurrence. Results A total of 64 female patients with an age range of 33 to 79 years were included. The means (SD) of age were 53.88 (11.02) and 54.88 (12.48) in the control and timolol groups, respectively. Considering the RTOG/EORTC and CTCAE scores the difference between groups was insignificant (P-Value = 0.182 and P-Value = 0.182, respectively). In addition, the mean (SD) of time of initial RID occurrence in placebo and timolol groups were 4.09 (0.588) and 4.53 (0.983) weeks, respectively (P-Value = 0.035). The maximum grade of RID over time was significantly lower in the timolol group. During the study period, 75.0% of patients in placebo groups had grade 2 of ARD while in the timolol group it was 31.3% (P-Value = 0.002). QoL was not significantly different between groups (P-Value = 0.148). Conclusion Although the topical formulation of timolol, 0.5% (w/w), was found to reduce the average maximum grade of ARD and increase the mean (SD) time of initial RID occurrence, it showed no effect on ARD, severity, and QOL. However, future clinical trials should be performed to assess timolol gel formulation in larger study populations. Trial registration https://irct.ir/ IRCT20190810044500N11 (17/03/2021).

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“…Some studies have shown that topical application of aloe vera gel can improve diarrhea symptoms in patients receiving pelvic radiotherapy. Gel was applied twice daily at a dose of 1 g for six weeks, 56 compared with a control group.…”

Section: Preventionmentioning

confidence: 99%

Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced rectal injury

Zhang,

Yuan

2023

Precision Radiation Oncology

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Although radiotherapy plays an important role in the treatment of cancer, it may have negative effects in some individuals. Rectal injury is a common adverse effect of abdominal and pelvic radiotherapy. This injury is caused by administering radiation to the abdomen. Appropriate treatment techniques can be determined if doctors have a better understanding of the incidence, risk factors, and clinical symptoms of radiation‐induced rectal injuries. Studies on the underlying pathophysiology of radiation‐induced rectal injury may aid in the development of effective treatment and prevention strategies. The implementation of efficient preventive measures can improve the quality of life of patients with cancer and make it easier for them to complete their treatment. Therefore, comprehensive and accurate assessments are crucial for developing holistic and individualized treatment plans for patients who have already developed symptoms, with early intervention being a priority.

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Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial

Cited by 5 publications

References 23 publications

Aloe Vera Como Estratégia De Cuidado De Enfermagem Para Tratamento De Pessoas Com Radiodermatites

Aloe Vera Como Estratégia De Cuidado De Enfermagem Para Tratamento De Pessoas Com Radiodermatites

Effects of topical timolol for the prevention of radiation-induced dermatitis in breast cancer: a pilot triple-blind, placebo-controlled trial

Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced rectal injury

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