Aloe vera incorporated biomimetic nanofibrous scaffold: a regenerative approach for skin tissue engineering

Suganya, S.; Venugopal, Jayarama Reddy; Mary, Soloman Agnes; Ramakrishna, Seeram; Lakshmi, Baddireddi Subhadra; Dev, V. R. Giri

doi:10.1007/s13726-013-0219-2

Cited by 91 publications

(95 citation statements)

References 26 publications

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“…In another study the addition of aloe vera (at 6%) resulted in finer and more homogeneous nanofibres with mean diameters of 150 to 350 nm [232]. A similar study on the hybrid of biodegradable PCL and aloe vera to prepare transdermal biomaterial showed homogeneity and small average diameters of the nanofibres in the presence of aloe vera (519±28 versus 215±63 nm at 10% aloe vera), and greatly improved mechanical properties and hydrophilicity [234].…”

Section: Aloe Vera With Synthetic/biopolymersmentioning

confidence: 96%

“…The metal enjoyed its success in a broad spectrum of consumer products, such as plastics, soaps, pastes, food and textiles. The antimicrobial and antifungal activity of silver nanoparticles (AgNP) makes it the most studied metal nanoparticle for different applications [234][235][236]. There are several ways by which ionic silver can be reduced into silver nanoparticles [26,238].…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

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A review on electrospun bio-based polymers for water treatment

Mokhena¹,

Jacobs²,

Luyt³

2015

Express Polym. Lett.

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Abstract. Over the past decades, electrospinning of biopolymers down to nanoscale garnered much interest to address most of the millennia issues related to water treatment. The fabrication of these nanostructured membranes added a new dimension to the current nanotechnologies where a wide range of materials can be processed to their nanosize. Electrospinning is a simple and versatile technique to fabricate unique nanostructured membranes with fascinating properties for a wide spectrum of applications such as filtration and others. These nanostructured membranes, fabricated by electrospinning, were found to be of a paramount importance because of their advanced inherited properties such as large surface-to-volume ratio, as well as tuneable porosity, stability, and high permeability. The extensive research conducted on these materials extended the success of electrospinning not only to bio-based polymer nanofibres, but to their hybrids and their derivatives. The technique also created avenues for advanced and massive production of nanofibres. This paper reviews the recent developments in the electrospinning technique. Electrospinning of biopolymers, their blends and functionalization using metals/metal oxides, and the potential applications of electrospun nanofibrous membranes in water filtration are discussed.

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Section: Aloe Vera With Synthetic/biopolymersmentioning

confidence: 96%

Section: Silver Nanoparticlesmentioning

confidence: 99%

A review on electrospun bio-based polymers for water treatment

Mokhena¹,

Jacobs²,

Luyt³

2015

Express Polym. Lett.

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“…Consequently, aloe vera has become an attractive candidate in the field of biomaterials. Aloe vera is especially attractive as a tissue engineering material because aloe vera promotes cell migration, proliferation, and growth [11,12,13,14,15,16,17]. …”

Section: Introductionmentioning

confidence: 99%

Aloe Vera for Tissue Engineering Applications

Rahman

Carter

Bhattarai

2017

JFB

158

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Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components. The bioactive components of aloe vera have effective antibacterial, anti-inflammatory, antioxidant, and immune-modulatory effects that promote both tissue regeneration and growth. The aloe vera plant, its bioactive components, extraction and processing, and tissue engineering prospects are reviewed in this article. The use of aloe vera as tissue engineering scaffolds, gels, and films is discussed, with a special focus on electrospun nanofibers.

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“…Even so, the investigation of osteogenesis with blended nanofibrous substrates of A. mylitta silk has not yet been carried out. PCL, being an aliphatic polyester, has certain recommended properties, like high mechanical strength and biodegradability, which account for its extensive use in drug delivery and bone tissue engineering (Suganya et al 2014;Lopez et al 2006). PCL, however, fails to provide a satisfactory environment for cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

“…The hydrophobic nature and the absence of any biological recognition site (Kurella and Dahotre 2005;Suganya et al 2014;Ghasemi-Mobarakeh et al 2008) account for the restricted use of PCL. Since it is desirable to counter the intrinsic hydrophobic nature of PCL, researchers have attempted to do so by inclusion of bioactive proteins like collagen (Zhang et al 2005a;Choi et al 2008), chitosan (Bhattarai et al 2009), and gelatin (Zhang et al 2005b;Chong et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Potential of inherent RGD containing silk fibroin–poly (Є-caprolactone) nanofibrous matrix for bone tissue engineering

et al. 2015

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The current study deals with the fabrication and characterization of blended nanofibrous scaffolds of tropical tasar silk fibroin of Antheraea mylitta and poly (Є-caprolactone) to act as an ideal scaffold for bone regeneration. The use of poly (Є-caprolactone) in osteogenesis is well-recognized. At the same time, the osteoconductive nature of the non-mulberry tasar fibroin is also established due to its internal integrin binding peptide RGD (Arg-Gly-Asp) sequences, which enhance cellular interaction and proliferation. Considering that the materials have the required and favorable properties, the blends are formed using an equal volume ratio of fibroin (2 and 4 wt%) and poly (Є-caprolactone) solution (10 wt%) to fabricate nanofibers. The nanofibers possess an average diameter of 152 ± 18 nm (2 % fibroin/PCL) and 175 ± 15 nm (4% fibroin/PCL). The results of Fourier transform infrared spectroscopy substantiates the preservation of the secondary structure of the fibroin in the blends indicating the structural stability of the neo-matrix. With an increase in the fibroin percentage, the hydrophobicity and thermal stability of the matrices as measured from melting temperature Tm (using DSC) decrease, while the mechanical strength is improved. The blended nanofibrous scaffolds are biodegradable, and support the viability and proliferation of human osteoblast-like cells as observed through scanning electron and confocal microscopes. Alkaline phosphatase assay indicates the cell proliferation and the generation of the neo-bone matrix. Taken together, these findings illustrate that the silk-poly (Є-caprolactone) blended nanofibrous scaffolds have an excellent prospect as scaffolding material in bone tissue engineering.

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Aloe vera incorporated biomimetic nanofibrous scaffold: a regenerative approach for skin tissue engineering

Cited by 91 publications

References 26 publications

A review on electrospun bio-based polymers for water treatment

A review on electrospun bio-based polymers for water treatment

Aloe Vera for Tissue Engineering Applications

Potential of inherent RGD containing silk fibroin–poly (Є-caprolactone) nanofibrous matrix for bone tissue engineering

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