Aloe vera : Potential candidate in health management via modulation of biological activities

Abstract

Treatment based on natural products is rapidly increasing worldwide due to the affordability and fewer side effects of such treatment. Various plants and the products derived from them are commonly used in primary health treatment, and they play a pivotal role in the treatment of diseases via modulation of biochemical and molecular pathways. Aloe vera, a succulent species, produces gel and latex, plays a therapeutic role in health management through antioxidant, antitumor, and anti-inflammatory activities, and also offers a suitable alternative approach for the treatment of various types of diseases. In this review, we summarize the possible mechanism of action and the therapeutic implications of Aloe vera in health maintenance based on its modulation of various biological activities.

Aloe Genus Plants: From Farm to Food Applications and Phytopharmacotherapy

“…Presently, they account among the most economically important medicinal plants and are commonly used in primary health treatment, where they play a pivotal role in the treatment of various types of diseases, through biochemical and molecular pathway modulation [ 4 ]. Indeed, Aloe plants have been reported for multiple biological properties, including antibacterial and antimicrobial, antitumor, anti-inflammatory, anti-arthritic, anti-rheumatoid, anticancer, and antidiabetic activities, detoxification, treating constipation, flushing out toxins and wastes from the body, promoting digestion (on gastrointestinal disorders treatment), and reducing illnesses likelihood, as well as for immune system deficiencies [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Besides, several clinical trials validated the use of Aloe gel against several diseases, such as diabetes or antihyperglycemic, wound, and burn-healing topical agents [ 5 , 10 , 11 ].…”

Phytochemical analysis and acaricidal activity of Aloe arborescens Mill. extracts against Rhipicephalus (Boophilus) microplus

“…Aloe is a genus characterized by the presence of anthraquinones, polyphenols, saponins, vitamins and minerals (LUCINI et al, 2015;RAHMANI et al, 2015). In this study, the qualitative analysis of the chemical composition of A. arborescens extracts showed that only water-soluble tannins were present in all fresh extracts, which indicates that all solvents (pure or mixed) were effective in the extraction of these secondary metabolites ( Figure 2).…”

Brief Challenges on Medicinal Plants: An Eye‐Opening Look at Ageing‐Related Disorders

“…It is known that the activation of fibroblast has been associated with enhancement of collagen and proteoglycan synthesis, subsequently to support tissue repair . Based on the currently available literature, approximately 75 potentially active ingredients were already proposed to be responsible for the observed effects; among them are vitamins, enzymes, minerals, sugars, lignin, saponins, salicylic acids and amino acids . Wound healing is one of the possible concerns in repairing trauma during ageing.…”

“…Also, it was reported that Aloe vera extract could induce considerable improvements in decreased CAT, SOD, GSH, GPx and glutathione‐ S ‐transferase levels in liver and kidney of diabetic rats, suggesting their immunomodulatory and antioxidant effects . For certain aspects, Aloe vera 's antioxidant activity seems to be strictly correlated with their anti‐inflammatory, free radicals‐ and superoxide radical‐scavenging effects, that is through reducing the production of prostaglandin E2 from arachidonic acid, inactivation of different transcription factors and even the activity of several enzymes, such as cyclooxygenase and lipoxygenase . Besides, the antioxidant potency of polysaccharides from Aloe vera against doxorubicin (DOX)‐induced myocardial oxidative stress in albino Wistar rats has also been shown, thus reporting insightful data about the cardiovascular disorders often related to aged individuals .…”