Aloe Vera vs. Silver Sulfadiazine for Treating Second-Degree Burn Wounds: Evidence-Based Case Report

Menna, Clara; Calista, Nabilla; Aurino, Leorca; Dwijayanti, Adisti

doi:10.22159/ijap.2019.v11s6.33580

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…One well-known antibacterial topical agent for burn wounds is SSD [ 7 ]. It was first introduced by Fox in 1967 and has become the most common topical agent for burn treatments [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Histological Studies on a Newly Isolated Bacillus subtilis D10 Protease in the Debridement of Burn Wound Eschars Using Mouse Model

et al. 2021

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Background: Proteases are among the most important industrial enzymes, playing a critical role in the physiological, biochemical, and regulatory processes of all living organisms. This study evaluated the histological effects of a Bacillus subtilis D10 protease in combination with the antibacterial ointment silver sulfadiazine (SSD) on the burned skin of mice. Materials and Methods: The bacterial proteolytic enzyme was produced and purified through DEAE-Sepharose CL-6B and Sephadex G-100 FF. The in vitro protease specificity was then determined. The dorsal skin of albino mice was burned with 80% HCl solution, then treated under three conditions: cold cream, SSD, and SSD combined with the tested protease. After 15 days of daily treatment, the mice were sacrificed and skin tissue samples were histopathologically examined using hematoxylin eosin, and Masson trichrome staining. Results: The D10 protease hydrolyzed the proteinaceous components of eschars (fibrin, normal collagen, and denatured collagen) in vitro. Mice skins treated with protease and SSD mixture showed promising results, with more rapid healing than the other treatments. This group regenerated epidermis and dermis with newly formed granulated follicles, fibroblasts and blood capillaries in the dermis, and collagen fibers in the hypodermis. Conclusions: These results suggest that the serine protease produced by B. subtilis D10 promotes wound healing of mice skin burnt with HCl and restores the normal architectural pattern in a shorter time than the standard treatments.

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“…One well-known antibacterial topical agent for burn wounds is SSD [ 7 ]. It was first introduced by Fox in 1967 and has become the most common topical agent for burn treatments [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Histological Studies on a Newly Isolated Bacillus subtilis D10 Protease in the Debridement of Burn Wound Eschars Using Mouse Model

et al. 2021

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“…A burn is an injury to organic tissue or skin primarily due to heat, chemicals, friction, electricity, or radioactivity. Thermal or heat burns occur when organic tissue or skin gets damaged due to exposure to heat [1]. The healing of burn injury involves three phases.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Copper Nanoparticles Loaded Hydrogel for Burns

Kumar

Pandit²,

Nagaich

2021

Int J App Pharm

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Objective: The present study focuses on the development and optimization of copper nanoparticles (CNPs) loaded hydrogel for the treatment of dermal burn injuries. Methods: CNPs gel was prepared by dispersing the variable concentration of polyvinylpyrrolidone (PVP K30) and hydroxypropyl methylcellulose (HPMC) in distilled water, PEG 400, and copper nanoparticles. factor screening study was performed for identification of influential factors, followed by optimization study using three-factor Box-Behnken design. Results: Optimized nanogel formulation, when compared to normal control (NC), shows a significant reduction of pro-inflammatory cytokines (IL-6 = 39.74 % and TNF-α =49.37%) and increased level of anti-inflammatory cytokines (IL-10 = 30.90%), indicating reduced inflammation. Further, the wound closure rate of CNPs gel shows significant (12.27 %) wound closure as compared to the NC group and complete wound closure (100 %) on the 14th day, indicating accelerated wound healing. Conclusion: the present investigation endorses accelerated scar-free, accelerated wound healing potential of copper nanoparticles gel with anti-inflammatory potential.

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Aloe Vera vs. Silver Sulfadiazine for Treating Second-Degree Burn Wounds: Evidence-Based Case Report

Cited by 2 publications

References 6 publications

Histological Studies on a Newly Isolated Bacillus subtilis D10 Protease in the Debridement of Burn Wound Eschars Using Mouse Model

Histological Studies on a Newly Isolated Bacillus subtilis D10 Protease in the Debridement of Burn Wound Eschars Using Mouse Model

Preparation and Evaluation of Copper Nanoparticles Loaded Hydrogel for Burns

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