Aloesin up‐regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK‐HEP‐1 cells

Lee, Kwang Youl; Park, Jeong Hill; Chung, Myung Hee; Park, Young In; Kim, Kyu Won; Lee, Young Joo; Lee, Seung Ki

doi:10.1080/15216549700201291

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…5b), flavonoids and tannins (Ali Khan et al, 2012). Similar anthraquinone glycosides have also been reported to stimulate cellular proliferation (Choi et al 2001;Lee et al 1997;Yagi et al 2002). It has been postulated that the proliferative effect of anthraquinone glycosides may be due to their high antioxidant activities (Araya-Maturana et al 2008;Gomes et al 2009).…”

Section: Wound Healingmentioning

confidence: 95%

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

2015

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Plants of the genus Terminalia are amongst the most widely used plants for traditional medicinal purposes worldwide. Many species are used for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, antioxidant, antiinflammatory and anticancer activities. Wound healing and cardiovascular effects have also been credited to some species. Many Terminalia species have multiple beneficial effects for multiple diseases and ailments. Indeed, the Indian species Terminalia chebula is known as the king of plants in Ayurveda due to its broad range of medicinal uses. However, apart from the reported ethnopharmacological uses of many Terminalia species, surprisingly few studies have rigorously examined this important genus for their medical properties/mechanisms and phytochemistry. This is likely due to the high tannin content common to many Terminalia species and the perception that these tannins may be responsible for much of their beneficial properties. As the complexities of tannins make them poor candidates for drug design, most interest in Terminalia species has been for their pharmacognostic and nutraceutical value and they have often been overlooked as potentials for drug discovery. However, recent reports have identified many other interesting phytochemicals and demonstrated that these may be responsible for several of the reported bioactivities of the Terminalia species used in traditional medicinal systems. The last decade has seen a large increase in the number of studies into the use of Terminalia species as therapeutic agents. Several species used in Ayurvedic medicine (Terminalia arjuna, Terminalia bellerica, Terminalia catappa, T. chebula) in particular have received much recent attention. Similarly, recent reports have also highlighted the medicinal potential of species from Africa, Australia and the Americas. The aim of this report is to summarise the recent research into the medicinal properties, phytochemistry and therapeutic mechanisms of Terminalia species and thus to highlight and direct future areas of research into the medicinal activities of this important genus.

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Section: Wound Healingmentioning

confidence: 95%

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

2015

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“…Chomones isolated from various Aloe species have been reported to have diverse biological activity. Aloesin have reportedly inhibited tyrosinase activity [8] and up-regulate cyclin E-dependent kinase activity [9]. Those chromones isolated from Aloe barbadensis also demonstrate anti-inflammatory [10] and antioxidant activity [11].…”

Section: Introductionmentioning

confidence: 99%

Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model

Yimam

Zhao

Corneliusen

et al. 2014

Diabetol Metab Syndr

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BackgroundThere are a few nutritional approaches to address the increased needs of managing diabetic conditions. Previously it has been reported that UP780, a standardized composition of aloe chromone formulated with an aloe polysaccharide, has a significant impact in reducing HbA1C, fasting blood glucose, fructosamine and plasma insulin level in humans and improved impaired glucose and insulin resistance in high-fat diet-induced and db/db non-insulin dependent diabetic mouse models. Here we describe activity of UP780 and its constituents to improve insulin sensitivity in alloxan induced insulin dependent diabetic mouse model.Materials and methodInsulin dependent diabetes was induced by administering a single intraperitoneal injection of alloxan monohydrate at a dose of 150 mg/kg to CD-1 mice. Aloesin (UP394) was formulated with an Aloe vera inner leaf gel powder polysaccharide (Qmatrix) to yield a composition designated UP780. Efficacy of oral administration of UP780 at 2000 mg/kg and its constituents (aloesin at 80 mg/kg and Qmatrix at 1920 mg/kg) were evaluated in this model. Glyburide, a sulfonylurea drug used in the treatment of type 2 diabetes, was used at 5 mg/kg as a positive control. Effect of UP780 on non-diabetic normal mice was also addressed.ResultsMice administered intraperitoneal alloxan monohydrate developed progressive type-1 diabetes like symptom. After 4 weeks of daily oral administration, reductions of 35.9%, 17.2% and 11.6% in fasting blood glucose levels were observed for UP780, the UP780 Aloe vera inner leaf gel polysaccharide preparation without chromone (Qmatrix), and Aloesin (UP394), treated animals respectively, compared to vehicle treated animals. UP780 has no impact on blood glucose level of non-diabetic healthy mice. UP780 showed statistically significant improvement for blood glucose clearance in oral glucose tolerance tests. Similarly, enhanced improvement in plasma insulin level and statistically significant reduction in triglyceride level was also observed for animals treated with the composition.ConclusionThese findings suggest that UP780, a chromone standardized Aloe based composition, could possibly be used as a natural supplement alternative to facilitate maintenance of healthy blood glucose levels.

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“…The Aloe vera chromone aloesin has also been reported to stimulate cellular proliferation. [51,61,99] It is possible that the proliferative effect of aloesin is due to its high anti-oxidant activity. [42,43] In contrast, cinnamic acid has been shown to down-regulate expression of cell proliferation and anti-apoptotic gene products, although the affects of both high and low concentrations were not examined.…”

Section: Antiseptic Activitymentioning

confidence: 99%

Problems of Reproducibility and Efficacy of Bioassays Using Crude Extracts, with reference to Aloe vera

Cock¹

2011

Phcog Commn.

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Aloe vera has a long history of medicinal usage and its biological activities have been well documented in a variety of bioassays. However, isolated Aloe vera leaf components generally do not display the same bioactivities, or have lower efficacies than crude juice/extracts. It is likely that several components work in a synergistic manner in the crude mixture, resulting in increased bioactivities. Furthermore, different laboratories often report varying bioactivities using the same extraction procedure on plant material from the same species. Individual Aloe vera cultivars may have widely varying levels of the bioactive phytochemicals. Due to the structure and chemical nature of many of the Aloe vera phytochemicals, it is likely that many of its reported medicinal properties are due to anti-oxidant or pro-oxidant effects. The anti-oxidant/prooxidant activities of many of Aloe vera's phytochemicals is dependent not only on their individual levels, but also on the ratios of various components, and on their individual redox states. Therefore, discrepancies between bioactivity studies are likely when using different crude mixtures. The potential differences between these crude mixtures need to be taken into account when analysing the reproducibility and efficacy of bioassays of crude extracts.

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Aloesin up‐regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK‐HEP‐1 cells

Cited by 14 publications

References 14 publications

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model

Problems of Reproducibility and Efficacy of Bioassays Using Crude Extracts, with reference to Aloe vera

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