Aloin From Aloe Vera Leaves: A Potential Natural Aluminium Detoxificant

Mahor, Gajendra; Ali, Sharique A.; Parveen, Naima

doi:10.21786/bbrc/12.2/41

Cited by 4 publications

(3 citation statements)

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“…SCFAs are well reported for their health benefits, such as decline of renal fibrosis, amelioration of tubular damage, decreasing serum creatinine and blood urea nitrogen, to improve the renal function 36 . Another study revealed that aluminium toxicity can result in renal damage and elevated levels of creatinine, urea, and uric acids; however, these toxic levels can be reduced by treatment with A. vera 37 . One more interesting study conducted by Tanomand et al .…”

Section: Discussionmentioning

confidence: 99%

Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)

Anand

Yoshida

Aoyagi

2021

Sci Rep

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Hyperphosphataemia is treated with phosphate binders, which can cause adverse effects. Spray-dried synbiotic powder (SP) composed of Lactobacillus casei JCM1134 (a phosphate-accumulating organism; PAO) and Aloe vera is potentially a safer alternative for efficient phosphate removal. In this study, a novel strategy was developed; lysine-derivatized deacetylated A. vera (DAVK) was synthesised and fabricated on phosphate-deficient PAO (PDP) for efficient phosphate transfer and then spray-dried with the supernatant of DAV centrifugation to form a sacrificial layer on PDP for SP integrity during gastric passage. In vitro experiments revealed that PAO removed only 1.6% of the phosphate from synthetic media, whereas SP removed 89%, 87%, and 67% (w/v) of the phosphate from milk, soft drink, and synthetic media, respectively, confirming the protective role of A. vera and efficient phosphate transport. Compared with commercial binders, SP effectively removed phosphate from synthetic media, whereas SP and CaCO3 exhibited comparative results for milk and soft drink. Importantly, CaCO3 caused hypercalcaemia. Thus, the described SP presents a promising tool to prevent hyperphosphataemia. This study also revealed a novel factor: diets of patients with chronic kidney disease should be monitored to determine the optimal phosphate binders, as phosphate removal performance depends on the accessible phosphate forms.

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Section: Discussionmentioning

confidence: 99%

Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)

Anand

Yoshida

Aoyagi

2021

Sci Rep

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“…Previous studies documented the potential effects of aloe vera in treating various toxicities in animal models. Aloe vera in AlP-exposed rats prevented renal damage [21]. Additionally, attractive studies have been conducted in the field of bio-engineering, where aloe vera was observed to block the surface-active sites of metals, particularly by the tan-nin compound of aloe vera [22].…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Acute Aluminum Phosphide Poisoning by Aloe Vera Syrup: A Case Report

Shakeri

Soroosh

Shakeri

et al. 2021

IJMTFM

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Background: Aluminum phosphide, known as rice pill in Iran, is a very effective pesticide for commercial and industrial ‎use. The high lethality of Aluminum phosphide is due to Phosphine gas (PH3) which is released by its ‎reaction with water. One of the most important properties of aluminum phosphide, which despite being ‎very lethal to almost all living creatures, still makes it one of the most widely used pesticides, is its very ‎high yield, ease of use, and, most importantly, the absence of residues in products after application; while ‎its exposure to the human body is associated with high mortality.‎ Case Presentation: In this article, we reported the successful treatment of rice pill-induced poisoning in a 30-year-old man using a novel approach. Accordingly, we used sodium bicarbonate (50 ccs) and aloe vera syrup (1-2 L), followed by olive oil (150 cc olive oil was given every 2 hours). Conclusion: While numerous studies recommend observing patient conditions as the treatment approach, our presented case was a successful experience of treating acute aluminum phosphide poisoning.

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“…11,12 The nanoformulation aloin preparation parameters, including the polymer concentration, time and concentrated stabilizers were optimized according to the method of central composite. 13,14…”

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confidence: 99%

Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability

Chauhan,

Singh,

Singh

et al. 2024

IJPQA

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This research aimed to prepare and assess an aloin nanoparticle that might increase its oral bioavailability. Utilizing the nanoprecipitation process, aloin Poly lactic-co-glycolic acid (PLGA) nanoparticulate was formulated and studied for the best strategy based on their characteristics and in-vitro release. The aloin nanoparticle stability research was evaluated at room temperature for a duration of three months. Additionally, pharmacokinetic (PK) tests were analyzed by using various parameters and experiments done by taking female wistar albino rats, with weights of approximately (150–200 gm). The animal was appropriately given the proper housing according to the protocol and placed in a period of twelve hours day and night. The drug was administered for 72 hours at a dosage of 10 mg/kg. of all the aloin nanoformulations developed, the one with the best size of particles was 98.5 nm with an entanglement efficacy of 98.09%. The results show that when compared to pure aloin, aloin PLGA nanoparticulate has a higher bioavailability.

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Aloin From Aloe Vera Leaves: A Potential Natural Aluminium Detoxificant

Cited by 4 publications

References 0 publications

Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)

Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)

Successful Treatment of Acute Aluminum Phosphide Poisoning by Aloe Vera Syrup: A Case Report

Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability

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