Alopecia and coeliac disease: report of two patients showing response to gluten-free diet

Arbato, B; Iola, V; Rillo, Giovanni; Ranchin, F; Russo, Luigi; Ucarelli, L; Rediani, F; Azzilli, M; Ardi, C

doi:10.1046/j.1365-2230.1998.00357.x

Cited by 11 publications

(9 citation statements)

References 4 publications

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“…We found no association of AA and CD, even though AA is associated with the CD susceptibility allele, HLA-DQB1*0201 [33]. There have been a few case reports of the co-occurrence of AA and CD [34, 35]. …”

Section: Discussionmentioning

confidence: 86%

Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives

Neuhausen

Steele

Ryan

et al. 2008

Journal of Autoimmunity

115

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The occurrence of other autoimmune diseases in celiac disease families has not been previously reported in a North American population. We investigated the familial aggregation of rheumatoid arthritis (RA), juvenile rheumatoid arthritis/juvenile idiopathic arthritis (JRA/JIA), hypothyroidism, insulin dependent diabetes mellitus (IDDM), and alopecia areata (AA) among individuals in families with celiac disease (CD). Family history information, obtained from questionnaires from the University of California Irvine Celiac Disease study, was reviewed for reports of RA, JRA/JIA, hypothyroidism, IDDM, and AA in celiac disease cases and their first-degree relatives. Reports of disease were compared with prevalence data from the literature and analyzed by calculating the standardized ratio (SR) with 95% confidence limits. We analyzed: 1) subjects with confirmed celiac disease or dermatitis herpetiformis (205 probands and 203 affected first-degree relatives) and 2) first-degree relatives of celiac disease cases (n=1,272). We found a significantly increased number of cases, relative to the expected number, of IDDM in both groups and hypothyroidism among subjects with celiac disease. JRA/JIA was increased among first-degree relatives of celiacs. These results indicate that the presence of IDDM within our celiac disease families may be due to shared genetic susceptibility predisposing to these diseases or autoimmune diseases in general.

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Section: Discussionmentioning

confidence: 86%

Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives

Neuhausen

Steele

Ryan

et al. 2008

Journal of Autoimmunity

115

View full text Add to dashboard Cite

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“…An association between AA and CD has recently been reported 7−12 . Both CD and AA are thought to have an immunological basis and, more specifically, a T‐cell‐immune dysregulation 13 .…”

Section: Discussionmentioning

confidence: 99%

Coeliac disease and alopecia areata in childhood

Fessatou

Kostaki

Karpathios

2003

J Paediatrics Child Health

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Coeliac disease is a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. The immune inflammatory response to gluten frequently causes damage to many other tissues of the body. We report the association of coeliac disease and alopecia areata in two children, a 13-year-old girl and a 29-month-old girl. Both of our patients had immunoglobulin A (IgA) class endomysial antibodies, IgA and immunoglobulin G (IgG) antigliadin antibodies and subtotal villous atrophy on jejunal biopsy. Administration of a gluten-free diet to our patients resulted in complete hair growth and improved the gastrointestinal symptoms.

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“…Younger patients and shorter lag times between the onset of alopecia areata and initiation of the GFD led to a more favorable hair growth response. Sex, lack of GI symptoms, and the severity of biopsy results did not appear to impact whether a patient would or would not have regrowth of hair [ 65 , 66 , 67 , 68 , 69 , 70 , 71 ].…”

Section: Alopeciamentioning

confidence: 99%