Alopecia androgénica masculina y factores de riesgo cardiovascular: estudio de casos y controles

Arias‐Santiago, Salvador; Gutiérrez-Salmerón, María Teresa; Castellote‐Caballero, Luisa; Buendía‐Eisman, A.; Naranjo‐Sintes, Ramón

doi:10.1016/j.ad.2009.10.002

Cited by 26 publications

(13 citation statements)

References 26 publications

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“…indicated that criteria for MetS were met by 57.1% of the patients with AGA compared to 14.3% of the controls. [18] Results of the current study are in conformity with these findings. However, Yi et al .…”

Section: Discussionsupporting

confidence: 90%

Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population

Chakrabarty

Hariharan²,

Gowda

et al. 2014

Int J Trichol

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Context:Although evidences for association of androgenetic alopecia (AGA) with metabolic syndrome (MetS) are accruing, inconclusiveness with respect to the gender specificity and differential association of MetS with increasing severity of AGA continues to persist. Furthermore, data specific to Indian settings are relatively sparse.Aims:The present study aimed at assessing the frequency of MetS in individuals with early AGA in Indian settings.Settings and Design:A case-control study was conducted at a trichology clinic in Bengaluru between April 2012 and September 2012 with a total of 85 cases of AGA and 85 age-matched controls.Materials and Methods:The Norwood-Hamilton classification was used to assess the grade of AGA. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Blood pressure, blood glucose, lipid parameters, and body mass index along with anthropometric measurements were assessed in all study participants.Statistical Analysis Used:Chi-square test was used to compare proportions between groups. Means were compared between groups using Student's t-test.Results:MetS was seen in a higher proportion of patients with AGA (43.5%) as compared to the control group (2.4%) and the differences were statistically significant (P < 0.001). As compared to controls, patients with AGA had higher triglycerides (P < 0.001), systolic blood pressure (P < 0.001), diastolic blood pressure (P < 0.001) along with significantly lower high-density lipoprotein cholesterol levels (P < 0.001). Severity of AGA was not associated with MetS.Conclusions:AGA is associated with MetS in male Indian patients aged <30 years. Studies with large sample sizes may be required to conclusively define any putative associations between AGA grades and MetS.

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Section: Discussionsupporting

confidence: 90%

Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population

Chakrabarty

Hariharan²,

Gowda

et al. 2014

Int J Trichol

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“…Recent meta‐analysis by Kim, et al highlighted the association between dyslipidaemia and AGA. The findings show significant increases in both total cholesterol and LDL levels, coupled to lower HDL, though the picture for HDL is less clear with some individual case studies reporting no changes or only small, non‐significant reductions in HDL . Total cholesterol and LDL levels were more consistently increased across the studies …”

Section: Associations Between Cholesterol and Hair Pathologiesmentioning

confidence: 92%

“…A number of studies have examined links between AGA and cholesterol levels, in particular focusing on cardiovascular disease risk and metabolic syndrome . Recent meta‐analysis by Kim, et al highlighted the association between dyslipidaemia and AGA.…”

Section: Associations Between Cholesterol and Hair Pathologiesmentioning

confidence: 99%

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Palmer

Blakeborough

Harries

et al. 2019

Experimental Dermatology

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Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remain largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies.

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“…Recent studies suggested an association of metabolic syndrome—obesity, hyperlipidaemia, hypertension and diabetes mellitus type 2 or abnormally high fasting blood glucose—with FPHL. As mutations in the melanocortin 4 receptor gene ( MC4R ) have been identified in patients with morbid obesity, and about half of the women in our FPHL sample present with obesity, we considered MC4R as an interesting candidate gene. Furthermore, this neuropeptide receptor has been detected among others in the dermal papilla of the hair follicle .…”

Section: Heritable Factors—the Present Status Of Fphl Genetic Researchmentioning

confidence: 99%

Genetics and other factors in the aetiology of female pattern hair loss

Redler

Messenger

Betz

2017

Experimental Dermatology

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Pattern hair loss is the most common form of hair loss in both women and men. Male pattern hair loss, also termed male androgenetic alopecia (M-AGA), is an androgendependent trait that is predominantly genetically determined. Androgen-mediated mechanisms are probably involved in female pattern hair loss (FPHL) in some women but the evidence is less strong than in M-AGA; other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Genome-wide association studies have identified several genetic loci for M-AGA and have provided better insight into the underlying biology. However, the role of heritable factors in and it has long been assumed that FPHL shares the same aetiology;hence, the term "female androgenetic alopecia" is often applied to this condition. However, the role of androgens in causing FPHL is less clear than in men. The genetic studies performed so far have not led to any firm conclusions but rather suggest different pathways for M-AGA and FPHL.In this review, we summarize what is known about the aetiology of FPHL and its relationship to M-AGA. Our main focus is on the results of genetic studies performed within the last decade. We also discuss the role of endocrine and other factors in the pathogenesis. | PREVALENCEPublished data on the prevalence of FPHL show some variation between studies, perhaps reflecting the difficulty in classifying mild forms of the condition. However, all show an increasing prevalence with age. Studies in women of white European ethnicity in the USA, [2] UK [3] and Australia [4] record a prevalence of 3%-12% in the third decade, rising to 14%-28% in the sixth decade and 29%-56%

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Alopecia androgénica masculina y factores de riesgo cardiovascular: estudio de casos y controles

Cited by 26 publications

References 26 publications

Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population

Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Genetics and other factors in the aetiology of female pattern hair loss

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