Alopecia Areata in the Elderly: A 10-Year Retrospective Study

Jang, Yong Hyun; Park, Kyung Hea; Kim, Sang Lim; Lim, Hyun Jung; Lee, Weon Ju; Lee, Seok Jong; Kim, Do Won

doi:10.5021/ad.2015.27.4.411

Cited by 10 publications

(23 citation statements)

References 17 publications

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“…In our study, approximately 10% of all patients with AA experienced onset at age 50 years and above. This coincides with data from previous epidemiological studies, which describe 14.5 and 7.1% of AA patients experiencing onset beginning at age 40 and 50, respectively [2,8,11] . While our results, like several other studies [10,11,13] , show a decline in incidence of lateonset AA with advancing age, it was not statistically significant, perhaps due to the small study group.…”

Section: Discussionsupporting

confidence: 78%

“…This coincides with data from previous epidemiological studies, which describe 14.5 and 7.1% of AA patients experiencing onset beginning at age 40 and 50, respectively [2,8,11] . While our results, like several other studies [10,11,13] , show a decline in incidence of lateonset AA with advancing age, it was not statistically significant, perhaps due to the small study group. Possible reasons for this decline may include an age-associated increase in the incidence and severity of androgenetic alopecia (AGA) and senescent alopecia, as well as hair graying (based on the theory that hair follicle melanocytes are the target for the immune system in AA) [10,11,14] .…”

Section: Discussionsupporting

confidence: 78%

“…While our results, like several other studies [10,11,13] , show a decline in incidence of lateonset AA with advancing age, it was not statistically significant, perhaps due to the small study group. Possible reasons for this decline may include an age-associated increase in the incidence and severity of androgenetic alopecia (AGA) and senescent alopecia, as well as hair graying (based on the theory that hair follicle melanocytes are the target for the immune system in AA) [10,11,14] . This decline in AA differs from the rise in various autoimmune disorders presumed to be caused by a decline in immunocompetence, seen with aging [15] .…”

Section: Discussioncontrasting

confidence: 55%

“…The course of AA is unpredictable; in eachand the definition of late-onset AA varies among authors. Two recent studies suggested a slight female predominance, a milder disease course, and a better prognosis with advancing age [6][7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

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Late-Onset Alopecia Areata: A Retrospective Cohort Study

et al. 2017

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Background: Alopecia areata is an immune-mediated disease presenting with sudden onset of nonscarring hair loss. Onset is more common earlier in life, and little is known regarding late-onset alopecia areata. Objectives: To describe the epidemiology, clinical patterns, disease course, and outcome of late-onset alopecia areata in Israeli patients referred to a tertiary medical center. Materials and Methods: This retrospective cohort study considered patients whose disease onset occurred at age ≥50 years. Patients were recruited from among all alopecia areata patients visiting a tertiary center between January 2009 and April 2015. Results: Of the 29 people included, 25 (86.2%) were female (female-to-male ratio, 6.2:1). There was a family history of alopecia areata in 17.2%, thyroid disease in 31%, atopic background in 6.9%, and 17/29 (58.6%) reported a significant stressful event. The most common disease pattern was patchy, and disease was mild in the majority of participants. Complete hair regrowth was observed in 82.8% of participants, and 37.9% relapsed. Conclusion: Late-onset alopecia areata is characterized by marked female predominance, less extensive disease, and a high incidence of complete hair regrowth.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 78%

Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

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Late-Onset Alopecia Areata: A Retrospective Cohort Study

et al. 2017

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“…There is no gender predilection [4]. Reported cases in elderly were of milder severity and had a better treatment response [5].…”

Section: Epidemiologymentioning

confidence: 99%

Alopecia Areata

Engın¹,

Oba²,

Tüzün³

2017

Hair and Scalp Disorders

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Alopecia areata is an organ-specific autoimmune disease targeting hair follicles. It causes nonscarring hair loss. The prevalence rate of the disease is approximately 1 in 1000 people worldwide. The condition is most commonly seen as circular areas of hair loss, but it may sometimes be as extensive as to involve the whole scalp or whole body. The complex pathophysiology of alopecia areata involves an autoimmune basis. Association of alopecia areata with other autoimmune diseases, such as thyroiditis and vitiligo, and the good response of patients to immunosuppressive treatment support an autoimmune etiology. Although some poor prognostic signs are defined, the course of the disease is unpredictable and the response to treatment can be variable. To date, there are neither preventive nor curative measures to deal with the condition. First-line therapy for patchy disease is topical and intralesional steroids, whereas extensive disease is conventionally managed with immunotherapy. New treatment agents, such as excimer laser, low-dose recombinant interleukin 2, Janus kinase inhibitors, and simvastatin/ezetimibe, are promising.

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