Alopecia Areata, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Autoimmunity and Apoptosis as Common Links?

Katsinelos, Panagiotis; Kountouras, Jannis; Paroutoglou, George; Zavos, Christos

doi:10.1007/s10620-006-9265-3

Cited by 9 publications

(9 citation statements)

References 39 publications

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“…Hypotheses regarding the pathogenesis of AA include a lymphocyte-mediated inflammation that suggests an underlying autoimmune etiology, an association with HLA class II antigen alleles, and contribution from environmental factors such as hormonal fluctuation, infectious agents, vaccinations, and stress. 1,[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Common treatment modalities include intralesional steroids and topical immunosuppresants. 13,[19][20][21][22][23] Alopecia areata has been reported to be associated with multiple comorbid conditions, including vitiligo, lupus erythematosus, psoriasis, atopy, thyroid disease, and mental health problems.…”

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confidence: 99%

“…13,[19][20][21][22][23] Alopecia areata has been reported to be associated with multiple comorbid conditions, including vitiligo, lupus erythematosus, psoriasis, atopy, thyroid disease, and mental health problems. 1,3,5,12,13,[24][25][26][27][28][29][30][31] Most of these studies are limited by small population size, homogeneous populations, or patient self-reported data. In this study, we used a novel algorithm to collate data on disease associations in a large retrospective patient cohort, allowing us to comprehensively evaluate the comorbid conditions among all individuals with AA seen at tertiary care hospitals in Boston, Massachusetts, during an 11-year period.…”

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confidence: 99%

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Autoimmune, Atopic, and Mental Health Comorbid Conditions Associated With Alopecia Areata in the United States

et al. 2013

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confidence: 99%

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confidence: 99%

Autoimmune, Atopic, and Mental Health Comorbid Conditions Associated With Alopecia Areata in the United States

et al. 2013

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“…Seventeen individual case studies described the association between hair loss and IBD ( n = 17, 35.2% female), with a mean patient age of 27.7 years [9, 21-24, 27, 34, 38, 43, 46, 48, 49, 51, 54, 56, 59, 61]. Of these 17 patients, 8 (47%) were diagnosed with AA (Table 3).…”

Section: Meta-analysismentioning

confidence: 99%

The Association between Alopecia and Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

et al. 2021

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Importance: The link between autoimmune gut disorders and different types of hair loss conditions has been recently investigated with an increased interest. With acknowledgement of the connection between immune dysregulation and the gut microbiome, this pathway is now becoming recognized as playing an important role in hair growth. The inflammatory cascade that results from the disruption of gut integrity such as seen in inflammatory bowel diseases (IBD) has been associated with certain types of alopecia. Objective: The aim of this work was to evaluate the association between alopecia and IBD. Evidence Review: A primary literature search was conducted using the PubMed, Embase, and Web of Science databases to identify articles on co-occurring alopecia and IBD from 1967 to 2020. A total of 79 studies were included in the review. A one-way proportional meta-analysis was performed on 19 of the studies to generate the pooled prevalence of alopecia and IBD. Finding: The pooled prevalence of non-scarring alopecia among IBD patients was 1.12% (k = 7, I2 = 98.6%, 95% CI 3.1–39.9); the prevalence of IBD among scarring and non-scarring alopecia was 1.99% (k = 12; I2 = 99%, 95% CI 6.2–34). The prevalence of non-scarring alopecia areata (AA) among IBD was compared to the prevalence of AA in the general population (0.63 vs. 0.1%; p < 0.0001). Similarly, the prevalence of IBD among the scarring and non-scarring alopecia groups was compared to the prevalence of IBD in the general population (1.99 vs. 0.396%; p = 0.0004). Conclusion: IBD and alopecia, particularly AA, appear to be strongly associated. Dermatology patients with alopecia may benefit from screening for IBD.

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“…In retrospective chart reviews, prevalence of alopecia in IBD patients were as low as 0.8-2% [169,170]. However, a cross-sectional questionnaire-based study revealed that hair loss was prevalent in 33% of IBD patients suggesting that patients may not always reveal this or consider this a symptom related to IBD unless asked [171].…”

Section: Alopeciamentioning

confidence: 99%

Symptom management in inflammatory bowel disease

Abraham

2015

Expert Review of Gastroenterology & Hepatology

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Patients with inflammatory bowel disease can present with a wide variety of symptoms. Most are related to disease activity and should be managed with appropriate medical therapy for inflammatory bowel disease. However, some patients may develop symptoms due to the side effects of the medications, or due to immunosuppression. In these cases, the offending medications should be discontinued until resolution of the symptoms and a few may be able to restart therapy. Symptoms can also occur as an extraintestinal manifestation of the disease or due to concomitant autoimmune-mediated disorders. Regardless of the etiology, symptoms should be addressed promptly with immediate evaluation and appropriate therapy, as a delay may lead to permanent sequela.

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Alopecia Areata, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Autoimmunity and Apoptosis as Common Links?

Cited by 9 publications

References 39 publications

Autoimmune, Atopic, and Mental Health Comorbid Conditions Associated With Alopecia Areata in the United States

Autoimmune, Atopic, and Mental Health Comorbid Conditions Associated With Alopecia Areata in the United States

The Association between Alopecia and Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Symptom management in inflammatory bowel disease

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