Alopecia Areata Progression Index, a Scoring System for Evaluating Overall Hair Loss Activity in Alopecia Areata Patients with Pigmented Hair: A Development and Reliability Assessment

Jang, Yong Hyun; Moon, Sun Young; Lee, Weon Ju; Lee, Seok Jong; Lee, Won Kee; Park, Byung Cheol; Kim, Hyojin; Kim, Do Won

doi:10.1159/000442816

Cited by 27 publications

(29 citation statements)

References 13 publications

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“…An alopecia areata progression index was also developed in which the scalp surface was divided into 4 quadrants. Hair loss in each quadrant was scored based on percentage of hair lost and clinical findings 132 .…”

Section: Mechanisms/pathophysiologymentioning

confidence: 99%

Alopecia areata

Pratt

King

Messenger

et al. 2017

Nat Rev Dis Primers

580

528

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Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. Hair loss can take many forms ranging from loss in well-defined patches to diffuse or total hair loss, which can affect all hair bearing sites. Patchy alopecia affecting the scalp is the most common type. Alopecia areata affects nearly 2% of the general population at some point during their lifetime. Skin biopsies of alopecia areata affected skin show a lymphocytic infiltrate in and around the bulb or the lower part of the hair follicle in anagen (hair growth) phase. A breakdown of immune privilege of the hair follicle is thought to be an important driver of alopecia areata. Genetic studies in patients and mouse models showed that alopecia areata is a complex, polygenic disease. Several genetic susceptibility loci were identified associated with signaling pathways that are important to hair follicle cycling and development. Alopecia areata is usually diagnosed based on clinical manifestations, but dermoscopy and histopathology can be helpful. Alopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the near future.

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Section: Mechanisms/pathophysiologymentioning

confidence: 99%

Alopecia areata

Pratt

King

Messenger

et al. 2017

Nat Rev Dis Primers

580

528

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“…Scoring indices used to assess the severity or treatment response in AA have some limitations. Quantifying the exact severity or treatment response in patients with AA of the beard area, eyebrows, or eyelashes is not possible through the use any of these scoring systems 8‐11 . It is important to realize that more than 50% of AA cases have involvement of these areas alone or in combination with scalp hair 6,7 .…”

Section: Discussionmentioning

confidence: 99%

“…The scoring system most commonly used in AA is “Severity of Alopecia Tool” (SALT) score 8 . Other scoring systems that are employed in AA include Alopecia Density and Extent (ALODEX) score, Alopecia Areata Progressive Index (AAPI) score, Alopecia Areata Predictive score, and SBN score 9‐11 . An important limitation of all these scoring systems is that only the scalp involvement can be properly and adequately assessed by them.…”

Section: Introductionmentioning

confidence: 99%

Alopecia areata severity index (AASI): A reliable scoring system to assess the severity of alopecia areata on face and scalp—a pilot study

Majid¹,

Sameem

Sultan

et al. 2021

J of Cosmetic Dermatology

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Background All scoring systems used in Alopecia Areata (AA) focus mainly on scalp and cannot assess the severity or treatment response when AA involves the beard hair, eyebrows, or eyelashes. Aim This study describes and assesses the reliability of a new scoring system “Alopecia Areata Severity Index” (AASI) for measuring the severity of AA of scalp, beard, and upper face. Methods Scalp hair, beard hair, upper face (eyebrows and eyelashes) were individually assessed and the severity of AA was scored from 0 to 100 (0–50 in case of upper face). AASI score was then calculated as a sum of all these individual scores as AASI = AASI (scalp) + AASI (upper face) + AASI (beard)+. To test the inter‐observer reliability of AASI score, 25 patients with varying severity of AA were scored by 4 trained dermatologists. Repeat scoring was performed after one week to test for intra‐observer reliability. Results Excellent inter‐rater, as well as intra‐observer reliability, was observed with Chronbach's alpha value of 0.999 (CI = 0.989–1.000). The intra‐observer correlation coefficient with average measure was 0.999 (CI = 0.990–1.000) with statistically significant F test <0.005. Conclusion AASI score is a reliable scoring system to assess the severity of AA in patients with involvement of one or more areas of the body. Limitations Sample population belonged to single ethnic group.

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“…However, as ED is being applied to many cutaneous ailments, other investigators would incorporate ED findings into diagnostic criteria of other skin diseases. Many dermoscopic features have, for example, been described for alopecia areata [18][19][20].…”

Section: Researchmentioning

confidence: 99%

Roles of Epiluminescence Dermoscopy beyond the Diagnoses of Cutaneous Malignancies and Other Skin Diseases

Chuh

2017

IJTDH

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Epiluminescence dermoscopy was developed mainly for the diagnoses of melanoma and other skin cancers. This technology is also being increasingly applied for the diagnoses of other cutaneous diseases. With rising popularity and availability, dermoscopes are taking up other roles. We discussed how dermoscopes facilitate education and counselling for patients and parents of patients, modify health-related behaviour, clinical research, and dermoscope-guided operations and procedures.

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Alopecia Areata Progression Index, a Scoring System for Evaluating Overall Hair Loss Activity in Alopecia Areata Patients with Pigmented Hair: A Development and Reliability Assessment

Cited by 27 publications

References 13 publications

Alopecia areata

Alopecia areata

Alopecia areata severity index (AASI): A reliable scoring system to assess the severity of alopecia areata on face and scalp—a pilot study

Roles of Epiluminescence Dermoscopy beyond the Diagnoses of Cutaneous Malignancies and Other Skin Diseases

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