Alopecia areata-successful outcome with microneedling and triamcinolone acetonide

Chandrashekar, BS; Yepuri, Vani; Mysore, Venkataram

doi:10.4103/0974-2077.129989

Cited by 67 publications

(31 citation statements)

References 2 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the collagen induction offered by MN is thought to counter steroid-induced atrophy as well as cause less pain than injection. 26 …”

Section: Alopeciamentioning

confidence: 99%

“…Chandrashekar et al analyzed outcomes from treating resistant AA with MN and topical corticosteroids. 26 Two adult patients with AA recalcitrant to ILK, topical steroids, and minoxidil 5% lotion received topical triamcinolone applied before and after Dermaroller. Both patients graded hair regrowth as “excellent” and had no recurrence at 3-month follow-up.…”

Section: Alopeciamentioning

confidence: 99%

See 1 more Smart Citation

Review of applications of microneedling in dermatology

Iriarte

Awosika

Rengifo‐Pardo

et al. 2017

CCID

145

131

View full text Add to dashboard Cite

Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of mainstay topical therapies across the thick stratum corneum. MN has become increasingly utilized over the last several years as it is a relatively simple procedure that is cost-effective, well tolerated, and offers both cosmetic and therapeutic benefits. The ability to treat localized areas of disease has led to numerous studies gauging its potential in focal diseases of inflammation, dyschromia, and photodamage. This review discusses the principles and evidence behind the expanding applications of MN. It has shown promising results as an adjuvant therapy for enhanced drug delivery in the treatment of atrophic scars, alopecia, actinic keratoses, and disorders of pigmentation such as melasma. The efficacy in treatment of vitiligo remains limited. Overall, the procedure has few adverse sequelae compared to other therapies, is highly efficacious, and is a viable resurfacing option for skin of color. Future research is needed to determine the frequency, interval, and specific device settings that foster optimal results. Additionally, large controlled trials are needed to shed light on the utility of MN as an evidence-based regimen for the treatment of various dermatologic conditions.

show abstract

“…However, the collagen induction offered by MN is thought to counter steroid-induced atrophy as well as cause less pain than injection. 26 …”

Section: Alopeciamentioning

confidence: 99%

Section: Alopeciamentioning

confidence: 99%

Review of applications of microneedling in dermatology

Iriarte

Awosika

Rengifo‐Pardo

et al. 2017

CCID

145

131

View full text Add to dashboard Cite

show abstract

“…The follicular bioavailability of Mx from this formulation and the potential use of such microparticles in targeting drug delivery for the topical treatment of alopecia are still being evaluated 14 . Microneedling-induced hair growth in mice has been also recently reported 15 , 16 . However, constructing suitable microneedles is problematic, and these needles may accidentally break and then remain in the skin 17 .…”

Section: Introductionmentioning

confidence: 78%

Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

Liao

Lin

et al. 2016

Theranostics

View full text Add to dashboard Cite

Minoxidil (Mx) is a conventional drug for treating androgenetic alopecia, preventing hair loss, and promoting hair growth. The solubility of Mx has been improved using chemical enhancement methods to increase its skin permeability over the long term. This study created a new ultrasound (US) contrast agent—albumin-shelled microbubbles (MBs) that absorb chitosan oligosaccharide lactate (COL) and Mx—and combined it with sonication by US energy in the water phase to enhance hair growth while shortening the treatment period. COL and Mx grafted with MBs (mean diameter of 1480 nm) were synthesized into self-assembled complexes of COL-MBs and Mx-COL-MBs that had mean diameters of 4150 and 4500 nm, respectively. The US was applied at 3 W/cm2 for 1 min, and combined with Mx-COL-MBs containing 0.3% Mx. The diffusion of Mx through the dialysis membrane from Mx-COL-MB during US (US+Mx-COL-MB) was more rapid at pH 4 than at pH 7.4, which is favorable given that the environment of the scalp is mildly acidic (pH=4.5-5.5). In Franz diffusion experiments performed in vitro, the release rates at 18 hours in the US+Mx-COL-MBs and US+MBs+Mx groups resulted in 2.3 and 1.7 times the penetration and deposition, respectively, of Mx relative to the group with Mx alone. During 21 days treatment in animal experiments, the growth rates at days 10 and 14 in the US+Mx-COL-MBs group increased by 22.6% and 64.7%, respectively, and there were clear significant differences (p<0.05) between the US+Mx-COL-MBs group and the other four groups. The use of US+Mx-COL-MB in the water phase can increased the effects of Mx so as to shorten the telogen phase, and also increase both the diameter of keratinized hair shafts and the size of hair follicles without causing skin damage.

show abstract

“…In another clinical study of two patients with alopecia areata, the application of triamcinolone acetonide by microneedling facilitated the absorption of the drug with its known immunomodulatory effect. 17 One more advantage of this combination in this condition could be that the collagen induced by microneedling may counter the possible atrophy caused by triamcinolone. Microneedling has also been used to enhance the penetration of minoxidil and to stimulate hair stem cells and growth factors in instances of alopecia androgenetica.…”

Section: Discussionmentioning

confidence: 99%

Microneedling dilates the follicular infundibulum and increases transfollicular absorption of liposomal sepia melanin

Serrano¹,

Almudever²,

Serrano³

et al. 2015

CCID

View full text Add to dashboard Cite

Encapsulation of chemicals in liposomes and microneedling are currently used techniques to enhance the penetration of several substances through skin and hair. In this study, we apply a liposomal melanin–fluorescein compound to an ex vivo model of human skin, using a new electrical microneedling device (Nanopore turbo roller). The product was applied by hand massage (A) or with the assistance of the electrical roller for 2 minutes (B). An additional test was performed free of product and with only the E-roller (C). Histological changes and product absorption were evaluated by optical and fluorescent microscopy 60 and 90 minutes after the treatment. Site B showed larger deposits of melanin–fluorescein at superficial and deep levels of hair structures in comparison to site A. Light, epidermal deposits of the melanin–fluorescein complex were also observed. Sites B and C showed a significant widening (47%) of the follicular infundibulum which could explain the increased penetration of the formulation. Microneedling also removed the scales and sebum residues in the neighborhood of the infundibulum. Targeting hair follicles with melanin may be useful to dye poorly pigmented hairs, improving laser hair removal. The procedure accelerates the delivery of melanin into hair structures allowing an even absorption, larger pigment deposits, and deeper penetration of the formulation into the hair.

show abstract

Alopecia areata-successful outcome with microneedling and triamcinolone acetonide

Cited by 67 publications

References 2 publications

Review of applications of microneedling in dermatology

Review of applications of microneedling in dermatology

Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

Microneedling dilates the follicular infundibulum and increases transfollicular absorption of liposomal sepia melanin

Contact Info

Product

Resources

About