Alopecia due to colour‐dilute follicular dysplasia in a horse

Henson, Frances; Stidworthy, Mark F.

doi:10.1111/j.2042-3292.2003.tb00249.x

Cited by 4 publications

(1 citation statement)

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“…Hair fibers with irregular pigmentation are prone to fracture (Rothstein et al 1998). These features are similar to color dilution alopecia, as described in a wide range of canine breeds (Rothstein et al 1998) and horses (Henson & Stidworthy 2003), suggesting that KRT71-congenital hypotrichosis of HF cattle is also a color-related genetic defect, except that the degree of pigmentary alteration seems to be milder.…”

Section: Discussionsupporting

confidence: 70%

Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay

Romero-Benavente,

Briano-Rodriguez,

Dutra-Quintela

2023

Pesq. Vet. Bras.

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Hypotrichosis congenita is a significant disease in Hereford cattle in Uruguay and has been reported worldwide. However, the causal mutation KRT71 has only been recently identified. This communication describes the clinical, histopathological, trichographic, and genetic findings of KRT71-hypotrichosis congenita observed in Hereford calves from two commercial farms. Five affected newborn calves, born in a herd of 15 purebred Polled HF cows, were examined in Farm 1, and one weaned calf in Farm 2. Skin biopsies for histopathology, hair samples for trichogram, and blood samples for genotyping were obtained from affected and control calves and the sire bull and mother cows. Affected animals exhibited a light brown coat with sparse, thin, curly or woolly haircoat. Hypotrichotic skin was dry, erythematous, and scaly. Trichogram analysis revealed thin, fragmented, curly hairs with irregular macro-melanosome groups. The main histopathological findings included marked follicular dysplasia with vacuolation, abnormally large trichohyaline granules in Huxley’s layer, and multiple melanin aggregates in hair fragments, matrix cells, and dysplastic follicles. There were no histological lesions of dermatitis. DNA analysis confirmed that hypotrichotic calves were homozygous for the KRT71 mutation, while one control calf, the bull, and cows in Farm 2 were heterozygous carriers. In conclusion, hypotrichosis congenita in Hereford cattle due to the KRT71 mutation is a color dilution follicular dysplasia.

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Section: Discussionsupporting

confidence: 70%