Alopecia Mucinosa Progressing into Mycosis Fungoides

Sentis, Henri J.; Willemze, Rein; Scheffer, E.

doi:10.1097/00000372-198812000-00002

Cited by 38 publications

(5 citation statements)

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“…Of greater significance is that proponents and opponents of this theory agree that no clinicopathologic criteria can reliably distinguish between primary and secondary FM. In most cases of FM associated with a lymphoproliferative disorder, patients develop FM and MF concomitantly, although lymphocytic malignancy may also arise several years after the diagnosis of FM (15,20,(24)(25)(26). Brown et al (27) state that, in the majority of cases, MF manifests within 5 years after the onset of FM.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Follicular Mucinosis: Presentation, Histopathology, Molecular Genetics, Treatment, and Outcomes over an 11‐Year Period at the Mayo Clinic

Alikhan

Griffin

Nguyen

et al. 2012

Pediatric Dermatology

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Follicular mucinosis (FM) and folliculotropic mycosis fungoides (MF) are rare in children, and data regarding long-term outcomes are limited. We sought to describe clinical and histopathologic findings of children with FM with and without MF, as well as treatments administered and clinical outcomes. We conducted a retrospective chart review of patients younger than 22 years (at time of diagnosis) with a biopsy demonstrating FM who were seen in the Dermatology Department at the Mayo Clinic from September 1, 1999, to September 1, 2010. Eleven patients (six male, five female) ages 11 to 19 years at the time of diagnosis met the inclusion criteria. Follow-up data were available for 10 patients, with a mean duration of 4.9 years. The head, neck, and extremities were the most common sites of involvement, and lesions were follicular-based papules (18%), scaly alopecic patches and plaques (45%), or a combination of the two (36%). Overall, three patients were confirmed to have MF. T-cell receptor gene rearrangement demonstrated clonality in two cases and was equivocal in one case. Treatments included topical corticosteroids, topical retinoids, oral minocycline, and, in patients with MF, ultraviolet light and topical bexarotene. Lesions resolved completely in seven patients, partially in one, and not at all in two (no follow-up data on one patient). Of the three patients with MF, two had complete resolution, and one has intermittent flares. To our knowledge, no patients developed other lymphoproliferative disorders. FM in children is rare. A histopathologic diagnosis of FM does not equate to folliculotropic MF in all cases. Most patients responded to treatment with topical steroids, topical retinoids, or phototherapy. In our series of patients, the disease ran a benign course.

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Section: Discussionmentioning

confidence: 99%

Pediatric Follicular Mucinosis: Presentation, Histopathology, Molecular Genetics, Treatment, and Outcomes over an 11‐Year Period at the Mayo Clinic

Alikhan

Griffin

Nguyen

et al. 2012

Pediatric Dermatology

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“…Divergent opinions have been expressed also regarding the presence or absence of epidermotropism. In addition, many different terms have been employed for what is probably one disease: follicular MF, 4–7,15,16 folliculotropic MF, 14 pilotropic MF, 17,18 folliculocentric MF, 19,20 MF presenting with follicular mucinosis, 2,21 MF‐associated follicular mucinosis 1 and basaloid folliculolymphoid hyperplasia with alopecia 22 as well as others 23–26 as an expression of MF. The various histologic criteria suggested by these authors do not facilitate the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Cytologic atypia and gene rearrangement studies were consistent with malignant lymphoma in both biopsies. Following the definition of follicular mucinosis‐associated MF as proposed by the Cutaneous Lymphoma Study Group of the EORTC 1 or as described by Sentis et al, 21 the first biopsy, despite having features of follicular mucinosis, would not fulfill their criteria since it had prominent epidermotropism. Our findings are in concordance with those by Kim et al 5 and Gilliam et al, 14 who also reported mucin in follicular MF.…”

Section: Discussionmentioning

confidence: 99%

Follicular mycosis fungoides. A histopathologic analysis of nine cases

et al. 2001

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“…334 Fibroblasts are slightly increased in number, with occasional stellate forms. 386,387 A study of T-cell clonality in follicular mucinosis has shown a monoclonal T-cell population in all patients with associated cutaneous T-cell lymphoma and also in 9 of 16 patients with the primary form of the disease. 331 A sparse inflammatory infiltrate composed of lymphocytes and eosinophils may be present in the mid dermis beneath the mucin deposit.…”

Section: Histopathologymentioning

confidence: 99%

Cutaneous mucinoses

Weedon

2010

Weedon's Skin Pathology

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Alopecia Mucinosa Progressing into Mycosis Fungoides

Cited by 38 publications

References 0 publications

Pediatric Follicular Mucinosis: Presentation, Histopathology, Molecular Genetics, Treatment, and Outcomes over an 11‐Year Period at the Mayo Clinic

Pediatric Follicular Mucinosis: Presentation, Histopathology, Molecular Genetics, Treatment, and Outcomes over an 11‐Year Period at the Mayo Clinic

Follicular mycosis fungoides. A histopathologic analysis of nine cases

Cutaneous mucinoses

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