2023
DOI: 10.21203/rs.3.rs-2904368/v1
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ALOX5 and ALOX5AP as an mRNA metric predicts unfavorable prognosis in lower-grade glioma

Abstract: The role of leukotrienes in glioma remains less understood. In this study, we explore the prognostic implication of leukotriene biosynthesis-related genes ALOX5 and ALOX5AP in lower-grade glioma (LGG) associated molecular underpinnings. The average expression of ALOX5 and ALOX5AP is defined as the ALOX score, which was positively associated with the malignant phenotype of LGG. Kaplan-Meier analysis and Cox regression analysis disclose that an increased expression of the ALOX score predicts an unfavorable outco… Show more

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