Aloysia triphylla infusion protects rats against dextran sulfate sodium-induced colonic damage

Lenoir, Loïc; Joubert‐Zakeyh, Juliette; Texier, Odile; Lamaison, Jean‐Louis; Vasson, Marie‐Paule; Felgines, Catherine

doi:10.1002/jsfa.5544

Cited by 26 publications

(13 citation statements)

References 14 publications

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“…Inflammatory bowel diseases (IBDs), particularly ulcerative colitis, have been long related to increased burden of oxidative stress (Achitei et al, 2013;Koutroubakis et al, 2004;Rezaie, Parker, & Abdollahi, 2007). To this regard, multiple studies revealed that antioxidant/antiinflammatory herbal extracts could be effective in the management of IBDs symptoms, particularly those related to increased oxidative stress (Chung et al, 2007;Lenoir et al, 2012;Ma et al, 2018;Zhang, Ma, Gao, Sun, & Zhang, 2017). In this context, a preliminary preclinical study was performed in order to evaluate protective effects of devil's claw in IBDs.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

Menghini

Recinella

Leone

et al. 2019

Phytotherapy Research

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Devil's claw (Harpagophytum procumbens) is an herbaceous plant, which can be found in the arid steppes of South Africa, particularly in the Kalahari Desert. As traditional medicine, devil's claw has been long used in the forms of infusions, decoctions, tinctures, powders, and extracts. The main compounds of devil's claw are iridoid glycosides, such as harpagoside, harpagide, and procumbide, which are present in the plant tubers. Additionally, chemical constituents such as sugars (mainly the tetrasaccharide stachyose), triterpenoids (oleanolic and ursolic acid), phytosterols (primarily β‐sitosterol), aromatic acids (caffeic, cinnamic, and chlorogenic acids), and flavonoids (luteolin and kaempferol) can be found in the plant. In order to investigate the applicative potential of devil's claw as therapeutic agent, we performed a review by focusing on its potential role in managing inflammation‐ and oxidative stress‐related diseases, including arthritis, osteoporosis, inflammatory bowel disease, low‐back pain, diabetes, and neurodegeneration.

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Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

Menghini

Recinella

Leone

et al. 2019

Phytotherapy Research

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“…The exploration of novel therapeutic methods is urgently needed. For exploring novel therapeutic methods of IBD, various studies have focused on the potential value of herbal extract, such as Scutellariae radix , Aloysia triphylla , Harpagophytum procumbens and Chamomile , and found that the herbal extracts have therapeutic effect in experimental model of IBD ( Chung et al, 2007 ; Lenoir et al, 2012 ; Menghini et al, 2016 ; Locatelli et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Exosomes Derived from Dendritic Cells Treated with Schistosoma japonicum Soluble Egg Antigen Attenuate DSS-Induced Colitis

Wang

Wan

et al. 2017

Front. Pharmacol.

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Exosomes are 30–150 nm small membrane vesicles that are released into the extracellular medium via cells that function as a mode of intercellular communication. Dendritic cell (DC)-derived exosomes modulate immune responses and prevent the development of autoimmune diseases. Moreover, Schistosoma japonicum eggs show modulatory effects in a mouse model of colitis. Therefore, we hypothesized that exosomes derived from DCs treated with S. japonicum soluble eggs antigen (SEA; SEA-treated DC exosomes) would be useful for treating inflammatory bowel disease (IBD). Exosomes were purified from the supernatant of DCs treated or untreated with SEA and identified via transmission electron microscopy, western blotting and NanoSight. Acute colitis was induced via the administration of dextran sulfate sodium (DSS) in drinking water (5.0%, wt/vol). Treatment with exosomes was conducted via intraperitoneal injection (i.p.; 50 μg per mouse) from day 0 to day 6. Clinical scores were calculated based on weight loss, stool type, and bleeding. Colon length was measured as an indirect marker of inflammation, and colon macroscopic characteristics were determined. Body weight loss and the disease activity index of DSS-induced colitis mice decreased significantly following treatment with SEA-treated DC exosomes. Moreover, the colon lengths of SEA-treated DC exosomes treated colitis mice improved, and their mean colon macroscopic scores decreased. In addition, histologic examinations and histological scores showed that SEA-treated DC exosomes prevented colon damage in acute DSS-induced colitis mice. These results indicate that SEA-treated DC exosomes attenuate the severity of acute DSS-induced colitis mice more effectively than DC exosomes. The current work suggests that SEA-treated DC exosomes may be useful as a new approach to treat IBD.

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“…Inflammatory bowel diseases (IBDs) are chronic disorders of the colonic mucosa (ulcerative colitis), whose etiology is strictly related to increased oxidative stress (Koutroubakis et al, 2004;Rezaie et al, 2007;Achitei et al, 2013). On the other hand, antioxidant/antiinflammatory herbal extracts were able to contrast oxidative stress-related IBD symptoms (Chung et al, 2007;Lenoir et al, 2012). Harpagophytum procumbens, traditionally known as devil's claw or Harpagophytum, is a plant species that has been long used for the treatment of inflammatory diseases, including degenerative rheumatoid arthritis, osteoarthritis and tendonitis (Chantre et al, 2000), kidney inflammation (Kaszkin et al, 2004) and heart disease (Circosta et al, 1984;Costa De Pasquale et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model

et al. 2017

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Harpagophytum procumbens has a long story of use for the treatment of inflammatory diseases. Considering both the antiinflammatory effects of H. procumbens in multiple tissues and the stability of harpagoside in artificial intestinal fluid, the aim of the present study was to explore the possible protective role of a microwave-assisted aqueous Harpagophytum extract (1-1000 μg/mL) on mouse myoblast C2C12 and human colorectal adenocarcinoma HCT116 cell lines, and isolated rat colon specimens challenged with lipopolysaccharide (LPS), a validated ex vivo model of acute ulcerative colitis. In this context, we evaluated the effects on C2C12 and HCT116 viability, and on LPS-induced production of serotonin (5-HT), tumor necrosis factor (TNF)-α, prostaglandin (PG)E and 8-iso-prostaglandin (8-iso-PG)F . Harpagophytum extract was well tolerated by C2C12 cells, while reduced HCT116 colon cancer cell viability. On the other hand, Harpagophytum extract reduced H O -induced (1 mM) reactive oxygen species (ROS) production, in both cell lines, and inhibited LPS-induced colon production of PGE , 8-iso-PGF , 5-HT and TNFα. Concluding, we demonstrated the efficacy of a microwave-assisted Harpagophytum aqueous extract in modulating the inflammatory, oxidative stress and immune response in an experimental model of inflammatory bowel diseases (IBD), thus suggesting a rational use of Harpagophytum in the management and prevention of ulcerative colitis in humans. Copyright © 2017 John Wiley & Sons, Ltd.

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Aloysia triphylla infusion protects rats against dextran sulfate sodium-induced colonic damage

Abstract: The results suggest that lemon verbena infusion partially protects rats against DSS-induced inflammation.

Cited by 26 publications

References 14 publications

Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

Exosomes Derived from Dendritic Cells Treated with Schistosoma japonicum Soluble Egg Antigen Attenuate DSS-Induced Colitis

Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model

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