Alpha and Beta Adrenergic Blocker-Resistant Release of Fibrinolytic Activity from Rat Venae cavae by Epinephrine In Vitro

Fracasso, J. F.; Rothschild, A. M.

doi:10.1055/s-0038-1657319

Cited by 2 publications

(1 citation statement)

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“…Adrenergic agonists were used to stimulate PA secretion as they have been shown to stimulate fibrinolytic activity in humans and other animals (3)(4)(5)(6)(7)(8)(9)(10). To start, we evaluated the time course, dose response and specificity of PA release using four adrenergic agonists (epinephrine, norepinephrine, isoproterenol and phenylephrine), and two antagonists (propranolol and phentolamine).…”

Section: Introductionmentioning

confidence: 99%

Adrenergic Stimulation of Regional Plasminogen Activator Release in Rabbits

1992

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SummaryThe purpose of this study was to determine whether different regions of the rabbit vascular system show variations in the rate of plasminogen activator (PA) secretion. To start, we evaluated the time course, dose response and adrenergic specificity of PA release. Infusion of 1 µg/kg of epinephrine stimulated a 116 ± 60% (SD) increase in PA activity that peaked 30 to 60 s after epinephrine administration. Infusion of 1 µg/kg of norepinephrine, isoproterenol and phenylephrine had no effect on PA activity. Pretreatment with phentolamine, an alpha adrenergic antagonist, blocked the release of PA by epinephrine while pretreatment with the beta blocker propranolol had no effect. This suggests that PA release in the rabbit was mediated by some form of alpha receptor.Significant arterio-venous differences in basal PA activity were found across the pulmonary and splanchnic vascular beds but not the lower extremity/pelvic bed. After stimulation with epinephrine, PA activity increased 46% across the splanchnic bed while no change was seen across the lower extremity/pelvic bed. We conclude that several vascular beds contribute to circulating PA activity in the rabbit, and that these beds secrete PA at different rates under both basal and stimulated conditions.

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