Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-Type GABA receptors

Huang, Chen; Li, Weiguang; Zhang, Xiaobing; Wang, Li; Xu, Tian‐Le; Wu, Di; Li, Yong

doi:10.1016/j.neuropharm.2012.09.001

Cited by 69 publications

(62 citation statements)

References 46 publications

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“…Pharmacological studies have proved that aasarone has effect on central nervous inhibitory, and was applied in epilepsy, asthma, and depression treatment (Lee et al 2014;Lu et al 2014;Huang et al 2013;Su et al 2014). However, the neuroprotective effects of b-asarone were highly suggested in recent studies, especially in AD investigation (Zou et al 2011;Liu et al 2010;Geng et al 2010;Wei et al 2013).…”

Section: Discussionmentioning

confidence: 99%

β-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer’s Disease

Yang

et al. 2015

Cell Mol Neurobiol

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Elevated β-amyloid (Aβ) is a hallmark of Alzheimer's disease (AD). Recent evidence has suggested that the receptor of advanced glycation end products (RAGE) is a key target for Aβ-induced perturbation in AD, and blockade of RAGE significantly alleviates synaptic injury. Our previous study has suggested that β-asarone could reduce neuronal apoptosis and improve memory deficits in β-amyloid precursor protein and presenilin-1 (APP/PS1) double transgenic AD-model mice. In the present study, we evaluated the effects of β-asarone on amyloidosis in APP/PS1 mice. We found that the survival of neurons of APP/PS1 mice was improved by β-asarone, meanwhile, β-asarone decreased Aβ deposition and down-regulated Aβ1-42 levels in cortex and hippocampus of APP/PS1 mice brain. Interestingly, the level of RAGE was also significantly down-regulated by β-asarone. Our findings suggest that β-asarone might be effective for the treatment of AD, and the decreasing effects of β-asarone on Aβ might associate with its down-regulation of RAGE.

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Section: Discussionmentioning

confidence: 99%

β-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer’s Disease

Yang

et al. 2015

Cell Mol Neurobiol

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“…Recently, several studies have shown that AAS inhibits the activity of hippocampal neurons and produces an antiepileptic effect in the CNS by enhancing tonic GABAergic inhibition [24]. Other studies have also reported that β-asarone can attenuate neuronal apoptosis in rat hippocampus and cognitive impairment associated with conditions, such Alzheimer's disease [25,26], and can reduce the toxicity of excitatory amino acids and increase the expression of c-fos in the epileptic rat brain [27].…”

Section: Discussionmentioning

confidence: 99%

Alpha-Asarone, a Major Component ofAcorus gramineus, Attenuates Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling Process

Lee

Sur

Yeom

et al. 2014

Korean J Physiol Pharmacol

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We investigated the anxiolytic-like activity of α-asarone (AAS) from Acorus gramineus in an experimental rat model of anxiety induced by repeated administration of the exogenous stress hormone corticosterone (CORT). The putative anxiolytic effect of AAS was studied in behavioral tests of anxiety, such as the elevated plus maze (EPM) test and the hole-board test (HBT) in rats. For 21 consecutive days, male rats received 50, 100, or 200 mg/kg AAS (i.p.) 30 min prior to a daily injection of CORT. Dysregulation of the HPA axis in response to the repeated CORT injections was confirmed by measuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Daily AAS (200 mg/kg) administration increased open-arm exploration significantly in the EPM test, and it increased the duration of head dipping activity in the HBT. It also blocked the increase in tyrosine hydroxylase (TH) expression in the locus coeruleus (LC) and decreased mRNA expression of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, in the hippocampus. These results indicated that the administration of AAS prior to high-dose exogenous CORT significantly improved anxiety-like behaviors, which are associated with modification of the central noradrenergic system and with BDNF function in rats. The current finding may improve understanding of the neurobiological mechanisms responsible for changes in emotions induced by repeated administration of high doses of CORT or by elevated levels of hormones associated with chronic stress. Thus, AAS did exhibit an anxiolytic-like effects in animal models of anxiety.

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“…174,175 α-asarone inhibits the activity of hippocampal neurons and produces antiepileptic effect in central nervous system through enhancing tonic GABAergic inhibition. 176 Food and Drug Administration banned usage its oil in food formulations and in other therapeutic preparations 177 due carcinogenic and toxic properties of β-asarone compound. 178 Ethanolic extract demonstrated to possess potential antioxidative, anti-inflammatory as well as neuroprotective actions.…”

Section: Introductionmentioning

confidence: 99%

Rasayana Herbs of Ayurveda to Treat age Related Cognitive Decline: An Update

Kulkarni¹,

Shetty²,

N³

et al. 2016

Phcogj

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Introduction: Cognitive decline associated with aging could be minor or major neuro-cognitive disorder presenting with progressive intellectual deterioration interfering with day to day activities. Behaviour and personality changes may complicate the life in due course. Significant increase in global prevalence of people aged above 60 years has raised concerns on effective management of old age problems. Age related cognitive deficits and dementia raise to the level of epidemics and established management is yet underway. Principles of preventive health and rasayana (rejuvenative) herbs of Ayurveda are being extensively researched up on for their effectiveness in dementia. In this fourteen such herbs with anti dementia property are discussed with relevant research update. Methods: Herbs like amalaki (Emblica officinalis), hareetaki (Terminalia chebula), haridra (Curcuma longa), manduka parni (Centella asiatica), aindri (Bacopa monniera), yastimadhu (Glycirrhiza glabra), guduchi (Tinospora cordifolia), shankhapushpi (Convolvulus pleuricaulis), vacha (Acorus calamus), jyotishmati (Celastrus panniculata), kushmanda (Benincasa hispida), Jatamamsi (Nardostachys jatamamsi), ashvagandha (Withania somnifera) and kapikacchu (Mucuna pruriens (Linn.)) are already proven of their efficacy in experimental and preclinical levels. The contents and research evidences are collected from ayurveda database on medicinal plants used in Ayurveda and Siddha and other authentic literature, Google scholar, Science direct, online and print journals. Discussion: The herbs in discussion mostly act on reactive oxygen species and oxidative stress injury by antioxidant properties and neuro-

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Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-Type GABA receptors

Cited by 69 publications

References 46 publications

β-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer’s Disease

β-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer’s Disease

Alpha-Asarone, a Major Component ofAcorus gramineus, Attenuates Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling Process

Rasayana Herbs of Ayurveda to Treat age Related Cognitive Decline: An Update

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