Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System

Abstract

Endocannabinoid (eCB) signaling plays an important role in the central nervous system (CNS). α/β-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids such as endocannabinoid 2-arachidonoyl glycerol (2-AG). ABHD6 participates in neurotransmission, inflammation, brain energy metabolism, tumorigenesis and other biological processes and is a potential therapeutic target for various neurological diseases, such as traumatic brain injury (TBI), multiple sclerosis (MS), epilepsy, mental illness, and pain. This review summarizes the molecular mechanisms of action and biological functions of ABHD6, particularly its mechanism of action in the pathogenesis of neurological diseases, and provides a theoretical basis for new pharmacological interventions via targeting of ABHD6.

Identification of hub genes significantly linked to tuberous sclerosis related-epilepsy and lipid metabolism via bioinformatics analysis

“…CPT1C is a member of the carnitine palmitoyltransferase 1 family and is involved in the regulation of physiological functions such as energy metabolism and feeding ( 38 ). CPT1C can have profound effects on brain physiology and total fatty acid profiles, which can be modulated by nutrients in the diet ( 39 ).…”

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“…5). ABHD6, a hydrolase of monoacylglycerols, regulates levels of the most abundant endocannabinoid, 2-araquidonoylglycerol, which is a modulator of neurotransmitter release through its binding to the endocannabinoid receptor CB1 at the neuron presynaptic membrane [54]. Importantly, CB1 has also been found in the external mitochondrial membrane, where it directly controls mitochondrial respiration and energy production [55].…”