Alpha-chloralose poisoning in cats: treatment with an intravenous lipid emulsion

Tegner, Cecilia; Lundgren, Sandra; Dreimanis, Kristoffer; Engdahl, Karolina; Windahl, Ulrika

doi:10.22233/9781913859152.39.3

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“…The log P of alpha-chloralose is reported between 0.85 and 1.0 depending on the literature, so the administration and therefore the benefit of ILE in this type of poisoning is questionable [ 32 , 33 ]. After data collection, a study by Tegner et al showed that, unfortunately, ILE is actually of no benefit, so that in the administration should rather be refrained in the case of alpha-chloralose intake [ 34 ]. However, the decision to administer ILE was made by the clinician in charge in the emergency situation due to suspected poisoning often not being aware of the final toxicant.…”

Section: Discussionmentioning

confidence: 99%

Clinical effects and adverse effects of intravenous lipid emulsion treatment in dogs and cats with suspected poisoning

Kiwitz,

Markert,

Dörfelt

2024

PLoS ONE

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This retrospective study aimed to evaluate the effects on the clinical signs of poisoning and adverse effects of intravenous lipid emulsion treatment in 82 animals (dogs and cats) with suspected poisonings over 18 months. Physical examination parameters and state of consciousness were documented every hour after the intravenous administration of a bolus of 2 ml/kg and 0.25 ml/kg/min over 60 minutes of a 20% intravenous lipid emulsion. The modified Glasgow coma scale and laboratory findings (blood gas analysis, triglyceride, lactate) were evaluated initially and three hours after discontinuing intravenous lipid emulsion administration. A statistical evaluation of the occurrence of adverse effects and the development of laboratory values was performed. A decrease in respiratory rate in the second control (8–12 hours) after ILE was observed. Three hours after completing of the intravenous lipid emulsion, triglyceride concentration increased about 10 times (p <0.001). Venous carbon dioxide partial pressure, bicarbonate, base excess, as well as the electrolytes sodium, potassium and ionized calcium decreased significantly (p <0.001). Patients who experienced a worsening of the modified Glasgow coma scale had a higher increase in triglyceride concentrations (p = 0.041) and plasma lactate (p = 0.034) and a larger decrease in bicarbonate concentrations (p = 0.053) compared to others. About 54% (n = 44) of the patients showed adverse effects which could be attributed to the administration of intravenous lipid emulsion and may be associated with a higher triglyceride increase. All of them were completely reversible within 33 hours. Adverse effects associated with intravenous lipid emulsion therapy were observed in half of the patients and were associated with a higher increase in triglycerides.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical effects and adverse effects of intravenous lipid emulsion treatment in dogs and cats with suspected poisoning

Kiwitz,

Markert,

Dörfelt

2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

Alpha-chloralose poisoning in cats: treatment with an intravenous lipid emulsion

Abstract: The objective of the study was to assess the effect of an intravenous lipid emulsion in the treatment of cats with alpha-chloralose poisoning.

Cited by 1 publication

References 0 publications

Clinical effects and adverse effects of intravenous lipid emulsion treatment in dogs and cats with suspected poisoning

Clinical effects and adverse effects of intravenous lipid emulsion treatment in dogs and cats with suspected poisoning

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