In the last three years, the most commonly occurring topic in people’s day-to-day dialogue has inevitably been the corona-virus disease 2019 (COVID-19). At the same time, it is embodied in various aspects of our lives. For example, keeping social distance, wearing masks, getting vaccinated, staying at home order, working at home have had an impact on people's lives. With the tendency of COVID-19 mutations, more people are being diagnosed or even dying. In addition to this, there is a significant risk of sequelae in those who are recovered. However, there are still no other options such as medical treatment to stop the occurrence of COVID-19 completely. Therefore, this research examines the changes affecting the causes of COVID-19 deaths for these conditions. While many researchers have explored relevant topics during the period affected by the epidemic, this research provides a fairly comprehensive overview of age (11 age groups), sex (male and female), vaccination status, and alterations in the overall number of diagnoses and fatality cases since COVID-19's inception up until the present. It is possible to obtain from the detailed investigation whether there is a significant relationship between COVID-19 and age, sex, and vaccination status. This research includes Box plots and Anova test for different age groups and sexes, and line graphs of the number of vaccinations, the amount of COVID-19 mortality in the United States, and the amount of COVID-19 confirmed cases and mortality worldwide to compare, interpret, and analyze the data to obtain conclusions.