Alpha-Fetoprotein-derived Segments as Integrin Peptidomimetics for Potential Cancer Cell Targeting and Therapy: A Review and Commentary

Abstract

The objectives in the present report comprise several in number. First, the integrin biologic functions and activities are described. Second, the types and family members of the heterodimeric celladhesion integrin molecules are discussed on an overview fashion. Third, naturally occurring peptides derived from "mother" proteins will be addressed as integrin-like peptidomimetics. Finally, a prime example of an integrin-like non-toxic peptide mimetic is described which displays activities such as inhibition of platelet aggregation, suppression of cell-to-matrix adhesion, cell migration/spreading, and cell-to-cell contact activities.