Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes

Herpen, T.W.J.M. van; Goryunova, S. V.; Schoot, J. van der; Mitreva, Makedonka; Salentijn, E.M.J.; Vorst, Oscar; Schenk, Martijn; Veelen, Peter A. van; Koning, Frits; Soest, Loek J M van; Vosman, Ben; Bosch, Dirk; Hamer, R.J.; Gilissen, L.J.W.J.; Smulders, M.J.M.

doi:10.1186/1471-2164-7-1

Cited by 438 publications

(321 citation statements)

References 27 publications

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“…Loss of the DHU arm from tRNA‐C has also been observed in other isopods, such as Ligia oceanica (Kilpert & Podsiadlowski, 2006) and Eophreatoicus sp.‐14 (Kilpert & Podsiadlowski, 2010). This feature might be a putative autapomorphy of isopoda, as it is absent in other malacostracan crustaceans.…”

Section: Discussionmentioning

confidence: 73%

“…A comparison of all 12 currently available isopod mt genomes, including four complete genomes (Kilpert & Podsiadlowski, 2006, 2010; Lloyd et al., 2015) and eight partial genomes (Chandler, Badawi, Moumen, Greve, & Cordaux, 2015; Kilpert, Held, & Podsiadlowski, 2012; Marcade et al., 2007; Podsiadlowski & Bartolomaeus, 2006), is shown in Figure 3. The putative ancestral state of the pancrustacean ground pattern is also provided (Boore, Lavrov, & Brown, 1998).…”

Section: Resultsmentioning

confidence: 99%

“…Considering the absence of trnQ in the L. oceanica mitogenome (Kilpert & Podsiadlowski, 2006), this is not an exception among isopods. Indeed, a lack of these genes is also common in arthropods, such as the absence of trnQ in Aleurodicus dugesii , trnS in Schizaphis graminum (Thao, Baumann, & Baumann, 2004), and trnD in Centruroides limpidus (Davila, Pinero, Bustos, Cevallos, & Davila, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Among crustacean mitogenomes, most share the ancestral pancrustacean (crustacean + hexapod) gene order that shows only a trnL‐UUR translocation relative to the ancestral arthropod arrangement found in the horseshoe crab Limulus polyphemus (Lavrov, Boore, & Brown, 2000) or present only minor tRNA translocations (Yang & Yang, 2008). Nonetheless, a broad comparison of mitochondrial (mt) gene order within Crustacea has revealed that some taxa exhibit greater variability, e.g., Copepoda, Cirripedia, Brachyura, and Isopoda (Kilpert & Podsiadlowski, 2006). …”

Section: Introductionmentioning

confidence: 99%

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The first complete mitogenome of the South China deep‐sea giant isopod Bathynomus sp. (Crustacea: Isopoda: Cirolanidae) allows insights into the early mitogenomic evolution of isopods

Shen

Kou

Zhong

et al. 2017

Ecology and Evolution

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In this study, the complete mitochondrial (mt) genome sequence of the South China deep‐sea giant isopod Bathynomus sp. was determined, and this study is the first to explore in detail the mt genome of a deep‐sea member of the order Isopoda. This species belongs to the genus Bathynomus, the members of which are saprophagous residents of the deep‐sea benthic environment; based on their large size, Bathynomus is included in the “supergiant group” of isopods. The mt genome of Bathynomus sp. is 14,965 bp in length and consists of 13 protein‐coding genes, two ribosomal RNA genes, only 18 transfer RNA genes, and a noncoding control region 362 bp in length, which is the smallest control region discovered in Isopoda to date. Although the overall genome organization is typical for metazoans, the mt genome of Bathynomus sp. shows a number of derived characters, such as an inversion of 10 genes when compared to the pancrustacean ground pattern. Rearrangements in some genes (e.g., cob, trnT, nad5, and trnF) are shared by nearly all isopod mt genomes analyzed thus far, and when compared to the putative isopod ground pattern, five rearrangements were found in Bathynomus sp. Two tRNAs exhibit modified secondary structures: The TΨC arm is absent from trnQ, and trnC lacks the DHU. Within the class Malacostraca, trnC arm loss is only found in other isopods. Phylogenetic analysis revealed that Bathynomus sp. (Cymothoida) and Sphaeroma serratum (Sphaeromatidea) form a single clade, although it is unclear whether Cymothoida is monophyletic or paraphyletic. Moreover, the evolutionary rate of Bathynomus sp. (dN/dS [nonsynonymous mutational rate/synonymous mutational rate] = 0.0705) is the slowest measured to date among Cymothoida, which may be associated with its relatively constant deep‐sea environment. Overall, our results may provide useful information for understanding the evolution of deep‐sea Isopoda species.

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Section: Discussionmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The first complete mitogenome of the South China deep‐sea giant isopod Bathynomus sp. (Crustacea: Isopoda: Cirolanidae) allows insights into the early mitogenomic evolution of isopods

Shen

Kou

Zhong

et al. 2017

Ecology and Evolution

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“…pollution) factors [10,11,12,13,14,15]. The expression of several other plant allergens has been shown to depend on maturation processes and varies in different cultivars [16,17,18,19,20,21,22]. Each of the latter factors may therefore affect the allergenicity of plant allergen sources.…”

Section: Introductionmentioning

confidence: 99%

Detection of Antigens Reactive to IgE and IgA during Wheat Seed Maturation and in Different Wheat Cultivars

Constantin¹,

Touraev

Heberle‐Bors

et al. 2009

Int Arch Allergy Immunol

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Background: Dietary intake of wheat causes hypersensitivity reactions in patients suffering from IgE-mediated food allergy and coeliac disease. Aim: To study the expression of IgE- and IgA-reactive antigens during wheat seed maturation and in different wheat cultivars. Methods: Summer wheat was grown in a glasshouse and seeds were harvested at defined maturation stages. Mature seeds were obtained from 13 different defined cultivars. Protein extracts were prepared from different maturation stages and cultivars with a standardized procedure based on seed weight and analysed by IgE and IgA immunoblotting using sera from clinically defined patients suffering from wheat allergy or coeliac disease. Results: With a few exceptions the expression of IgE- and IgA-reactive wheat antigens increased during wheat seed maturation. Wheat cultivars could be identified in which the expression of certain IgE- and IgA-reactive components was strongly reduced or not detectable. Conclusions: The expression of IgE- and IgA-reactive antigens depends on wheat seed maturation and varies in different wheat cultivars.

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Wheat Proteins

Juhász

Békés²,

Wrigley

2014

Applied Food Protein Chemistry

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Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes

Abstract: Background: Bread wheat (Triticum aestivum) is an important staple food. However, wheat gluten proteins cause celiac disease (CD) in 0.5 to 1% of the general population. Among these proteins, the α-gliadins contain several peptides that are associated to the disease.

Cited by 438 publications

References 27 publications

The first complete mitogenome of the South China deep‐sea giant isopod Bathynomus sp. (Crustacea: Isopoda: Cirolanidae) allows insights into the early mitogenomic evolution of isopods

The first complete mitogenome of the South China deep‐sea giant isopod Bathynomus sp. (Crustacea: Isopoda: Cirolanidae) allows insights into the early mitogenomic evolution of isopods

Detection of Antigens Reactive to IgE and IgA during Wheat Seed Maturation and in Different Wheat Cultivars

Wheat Proteins

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