Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus

Moelands, Suzanne Vl; Lucassen, Peter; Akkermans, Reinier; Grauw, Wim Jc De; Laar, F.A. van de

doi:10.1002/14651858.cd005061.pub3

Cited by 34 publications

(29 citation statements)

References 88 publications

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“…Another important pathway involved in carbohydrate metabolism is α-glucosidase enzyme, which converts disaccharides into monosaccharides at the cells lining the intestine. In diabetic patients, the short-term effect of these drugs therapies is to decrease current blood glucose levels [26]. GG03 and GD did not inhibit α-glucosidase.…”

Section: Discussionmentioning

confidence: 99%

Steamed Ginger May Enhance Insulin Secretion through KATP Channel Closure in Pancreatic β-Cells Potentially by Increasing 1-Dehydro-6-Gingerdione Content

et al. 2020

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Ginger (Zingiber officinale Roscoe) and its active compounds (gingerols, shogaols and paradols) have been reported as having beneficial functions for several diseases, including diabetes. In this study, we revealed that the steaming process could enhance the anti-diabetic potential of ginger. To confirm the anti-diabetic effect of steamed ginger extract (GG03), we assessed pancreatic islets impaired by alloxan in zebrafish and demonstrated anti-hyperglycemic efficacy in a mouse model. The EC50 values of ginger extract (GE) and GG03 showed that the efficacy of GG03 was greater than that of GE. In addition, LC50 values demonstrated that GG03 had lower toxicity than GE, and the comparison of the Therapeutic Index (TI) proved that GG03 is a safer functional food. Furthermore, our data showed that GG03 significantly lowered hyperglycemia in a diabetic mouse model. HPLC was performed to confirm the change in the composition of steamed ginger. Interestingly, GG03 showed a 375% increase in 1-dehydro-6-gingerdione (GD) compared with GE. GD has not yet been studied much pharmacologically. Thus, we identified the protective effects of GD in the damaged pancreatic islets of diabetic zebrafish. We further assessed whether the anti-diabetic mechanism of action of GG03 and GD involves insulin secretion. Our results suggest that GG03 and GD might stimulate insulin secretion by the closure of KATP channels in pancreatic β-cells.

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Section: Discussionmentioning

confidence: 99%

Steamed Ginger May Enhance Insulin Secretion through KATP Channel Closure in Pancreatic β-Cells Potentially by Increasing 1-Dehydro-6-Gingerdione Content

et al. 2020

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“…In addition, although there are no unified views [ 21 , 22 , 23 ], it has been reported that long-term acarbose treatments improve insulin sensitivity [ 22 , 23 ] and secretion [ 23 ]. The efficacy of α -glucosidase inhibitors for preventing or delaying the onset of type 2 diabetes had been suggested in individuals with impaired glucose tolerance (IGT) and those at an increased risk for diabetes [ 24 ]. Therefore, the HPGA natto may also contribute to the prevention of IGT and type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Gamma-Polyglutamic Acid-Rich Natto Suppresses Postprandial Blood Glucose Response in the Early Phase after Meals: A Randomized Crossover Study

et al. 2020

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We evaluated the suppressive effects of high-gamma-polyglutamic acid (γ-PGA) natto on postprandial blood glucose level and insulin response. After confirming the eligibility of candidates using a pre-selective test with packaged white rice, a meal loading test including low- or high-γ-PGA natto (with 57.6 mg (LPGA) and 439.6 mg (HPGA) of γ-PGA, respectively) was conducted in men aged 20 to 70 years (n = 29) and postmenopausal women aged ≤70 years (n = 7). On each examination day, blood samples were obtained after they fasted overnight and for 120 min after test meal loading. The primary outcome of this study was the difference between the measurements of the incremental area under the curve (IAUC) for blood glucose 0 to 30 min after loading of LPGA and HPGA meals. The IAUCs for blood glucose and insulin after the HPGA meal were lower than those after the LPGA meal within 45 min (0 to 15 and 0 to 30 min: p < 0.001, 0 to 45 min: p < 0.01) and 1 h (all p < 0.001) of loading, respectively. The suppressive effects of HPGA natto on postprandial glucose response in the early phase, which possibly relates to the risk of dysglycemia and cardiovascular disease, were clarified.

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“…This means the alpha-glucosidase complexes are competitively inhibited and their availability to oligosaccharides from dietary starch is reduced. Thus, monosaccharide formation decreases and less insulin is required to metabolize glucose, leading to a reduction of food induced increases in blood glucose and insulin (Moelands et al, 2018).…”

Section: Current T2dm Drug Treatments In New Zealandmentioning

confidence: 99%

The Potential of Anti-Diabetic Rākau Rongoā (Māori Herbal Medicine) to Treat Type 2 Diabetes Mellitus (T2DM) Mate Huka: A Review

Koia

Shepherd

2020

Front. Pharmacol.

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T2DM (type 2 diabetes mellitus, or Maōri term "mate huka") is a major long-term health issue in New Zealand particularly among the Maōri community. Non-insulin drugs commonly used in New Zealand for the treatment of T2DM have limits to their efficacy as well as side effects, which are of concern for diabetics. As such, the potential for natural products such as traditional rakau rongoāare of interest for potentially preventing the development of T2DM or improving the treatment of the disease. In particular, antidiabetic effects have been reported for rakau rongoāsuch as karamu, kumarahou, and kawakawa. Natural products have been identified in karamu, kumarahou, and kawakawa that have documented potential effects on glucose metabolism that could contribute to the anti-diabetic effect of these rakau rongoa. As such, this could provide scientific insight into the matauranga (traditional knowledge) developed over generations by Maōri. However, detailed laboratory based and clinical studies would be required to understand and validate these properties of karamu, kumarahou, and kawakawa, and to understand how they can be used in T2DM treatment. Social determinants of indigenous health such as language, culture, traditional knowledge, and identity, are important in understanding the relationship Maōri have with their land and the matauranga they developed of the medicinal properties within their rakau rongoa, over many centuries. Interestingly, traditional Maōri views towards scientific research using animal models to test rakau rongoāare varied but supportive. Furthermore, cultural issues surrounding Maōri mana motuhake (self-determination) of traditional rongoāMaōri healing practices and the inequity faced by many kairongoā(rongoāMaōri practitioners) and tohunga (healers) compared to mainstream health are a current issue within the New Zealand health system. As such, a cultural holistic approach for T2DM care among Maōri would be advantageous. This review will outline the available evidence supporting the anti-diabetic efficacy of karamu, kumarahou, and kawakawa. Currently though there is a lack of molecular research to understand the mechanisms of this efficacy, as such this review will

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Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus

Abstract: Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus.

Cited by 34 publications

References 88 publications

Steamed Ginger May Enhance Insulin Secretion through KATP Channel Closure in Pancreatic β-Cells Potentially by Increasing 1-Dehydro-6-Gingerdione Content

Steamed Ginger May Enhance Insulin Secretion through KATP Channel Closure in Pancreatic β-Cells Potentially by Increasing 1-Dehydro-6-Gingerdione Content

Gamma-Polyglutamic Acid-Rich Natto Suppresses Postprandial Blood Glucose Response in the Early Phase after Meals: A Randomized Crossover Study

The Potential of Anti-Diabetic Rākau Rongoā (Māori Herbal Medicine) to Treat Type 2 Diabetes Mellitus (T2DM) Mate Huka: A Review

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