.ALPHA.-Glucosidase Inhibitors from Garcinia brevipedicellata (Clusiaceae)

Ngoupayo, Joseph; Tabopda, Turibio Kuiate; Ali, Muhammad; Tsamo, Etienne

doi:10.1248/cpb.56.1466

Cited by 32 publications

(15 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…α-Glucosidase inhibitors demonstrated a large clinical importance in the treatment of type II diabetes, and this therapeutic class is mainly sustained by acarbose, miglitol, and voglibose, the 3 of them being derived from natural products [5][6][7]. Despite the close structural homologies between these clinically-approved inhibitors (carbasugars and iminosugars), polyphenolics pertaining to typical lichen metabolite series were repeatedly reported to exert promising α-glucosidase inhibitory activities: depsides [8], depsidones [9,10], diphenylethers [11], fungal xanthones [11], terphenylquinones, and pulvinic acid derivatives [12].…”

Section: Introductionmentioning

confidence: 99%

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

et al. 2020

View full text Add to dashboard Cite

Three new depsidones, parmosidones F – G (1 – 2), and 8′-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A – C (4 – 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1 and 2 in particular inhibited α-glucosidase with IC50 values of 2.2 and 4.3 µM, respectively, and are thus more potent than the positive control, acarbose.

show abstract

Section: Introductionmentioning

confidence: 99%

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Analysis of HMBC correlations cannot help to differentiate the two chemical shifts. However, further analysis of NMR data for existing structures revealed that the 13 C chemical shift of C‐5a is always higher than that of C‐9a. This observation is crucial in determining the structure of the depsidone B ring.…”

Section: Resultsmentioning

confidence: 98%

Oliveridepsidones A–D, antioxidant depsidones from Garcinia oliveri

Hansen

Duus

et al. 2012

Magnetic Reson in Chemistry

View full text Add to dashboard Cite

show abstract

“…Some plants of Garcinia species have been studied scientifically and are known to have activity as an antidiabetic, among others Garcinia brevipedicellata [5], Garcinia mangostana [6], Garcinia nobilis [7], and Garcinia hanburyi [8]. The bioactive compounds that play a role in the α-glucosidase inhibitor from each of these plants that brevipsidones D, prenylated xanthones, xanthones, and polyprenylated xanthones [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…The bioactive compounds that play a role in the α-glucosidase inhibitor from each of these plants that brevipsidones D, prenylated xanthones, xanthones, and polyprenylated xanthones [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

COMPARISON OF INHIBITORY ACTIVITY AGAINST THE Α-Glucosidase ENZYMES IN THE EXTRACTS AND FRACTIONS FROM LEAVES OF THE GARCINIA KYDIA ROXBURGH

Martha

Elya

Hanafi

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Garcinia kydia Roxb. is a species of the genus Garcinia, is based chemotaxonomic has various bioactive compounds that have been isolated by a variety of pharmacological activities, one of the activities that are being developed that inhibition of α-glucosidase. However, α-glucosidase inhibitory activity in the extracts and fraction from leaves of the G. kydia Roxb. has not been reported. In this study, seeks to evaluate of α-glucosidase inhibitory activity against extracts and fractions of potentially. Methods:The α-glucosidase inhibitory activity test conducted by in vitro using the enzymatic reaction is measured of quantity with a microplate reader and identifies the compound from the active fraction with normal-phase thin layer chromatography. Results:The ethyl acetate and methanol extract have the potential to inhibit the α-glucosidase with the percent inhibition at a concentration of 500 µg/ml of 83% and 59%, respectively. The active fraction of the ethyl acetate extracts (FEA8) with percentage inhibition at concentrations of 100 µg/ml and inhibitory concentration (IC 50 ) values of 80% and 2.79 μg/ml, respectively, and active fraction of the methanol extracts (FMT3) with percent inhibition at concentrations of 100 µg/ml and IC 50 values of 71% and 8.43 μg/ml, respectively. Conclusion: G. kydiaRoxb. evident has the potential to inhibit the α-glucosidase. Flavonoid and phenolic compounds that suspected of acts as α-glucosidase inhibitory activity. Thus, the research will continue the process of isolating the active compound so that it can be developed as natural therapeutic agents in the control of glucose.

show abstract

.ALPHA.-Glucosidase Inhibitors from Garcinia brevipedicellata (Clusiaceae)

Cited by 32 publications

References 21 publications

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

Oliveridepsidones A–D, antioxidant depsidones from Garcinia oliveri

COMPARISON OF INHIBITORY ACTIVITY AGAINST THE Α-Glucosidase ENZYMES IN THE EXTRACTS AND FRACTIONS FROM LEAVES OF THE GARCINIA KYDIA ROXBURGH

Contact Info

Product

Resources

About