Alpha-glucosidase inhibitory activities of bungur (Lagerstroemia loudonii Teijsm. & Binn.) leaves and fruits

Abstract

Bungur ( Lagerstroemia loudonii Teijsm. & Binn.) belongs to the Lytrhaceae that traditionally was used as antidiabetic, antiinflammatory, antihypertensive and diuretic. Other bungur plants such as Lagerstroemia speciosa have been known for the activity as alpha-glucosidase inhibitor. Based on chemotaxonomy, the distribution of compounds in one family or genus and its activity has similarities, then tested for the activity of alpha-glucosidase of Lagerstroemia loudonii Teijsm. & Binn. The leaves and fruits was extracted by reflux using 96% ethanol. The process of fractionation by liquid-liquid extraction. Testing of alpha-glucosidase inhibitor activity was performed in vitro using colorimetric method at 400.4 nm, acarbose used as standard inhibitor. The results of alpha-glucosidase inhibitory activity of leaves with IC50 showed the ethanol extracts, n-hexane, ethyl acetate and water fractions respectively 262.20 pg/ml; 97.16 pg/ml; 62.73 pg/ml; 145.30 pg/ml; and fruits with IC50 showed the ethanol extracts, n-hexane, ethyl acetate and water fractions respectively 1.50 pg/ml; 3.69 pg/ml; 37.38 pg/ml; 22.59 pg/ml. IC50 standard acarbose was 10.95 pg/ml. The results of this research from Lagerstroemia loudonii Teijsm. & Binn. leaves and fruits can be developed into herbal preparations to lower blood glucose levels.

Evaluation of non-timber forest products used as medicinal plants from East Kalimantan (Indonesia) to inhibit ?-glucosidase and free radicals

“…A previous Kolakul and Sripanidkulchai (2017) study reported that L. speciosa contains phenolic groups such as ellagic acid, epicatechin gallate, and gallic acid. In addition, a previous study by Riyanti et al (2020) reported Lagerstroemia loudonii Teijsm. & Binn exhibited inhibitory activity against yeast α-glucosidase.…”

Potensi Daun Bungur (Lagerstroemia loudonii Teijsm. & Binn.) Yang Gugur Sebagai Penghambat Alfa-Glukosidase

“…Aktivitas penghambatan alfaglukosidase ekstrak etanol daun bungur yang gugur lebih besar dibandingkan dengan ekstrak etanol daun bungur yang masih berwarna hijau dan fraksi air daun bungur yang gugur memberikan aktivitas penghambatan alfa-glukosidase yang terbesar dengan IC50 134,27 µg/mL. Riyanti et al, 2020). Selain itu dari daun bungur baik yang masih berwarna hijau ataupun yang gugur berwarna kuning dilaporkan memiliki aktivitas antioksidan dengan nilai nilai IC50 berturut-turut sebesar 7,53 µg/ml; dan 25,87 µg/ml (Soraya Riyanti & Windyaswari, 2019).…”

The complete chloroplast genome of Lagerstroemia loudonii Teijsm. & Binn. (Lythraceae), an ornamental tree with medicinal value

“…In addition to the high ornamental value, L. loudonii also has medicinal value, with its leaves being used in traditional medicine to treat diabetes, inflammatory, and obesity in East Asia (Riyanti et al. 2020 ). At present, the research of L. loudonii is mainly focused on chemical constituents and pharmacology.…”