2021
DOI: 10.3390/molecules26082257
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Alpha-Glucosidase Inhibitory Diterpenes from Euphorbia antiquorum Growing in Vietnam

Abstract: Bioactive-guided phytochemical investigation of Euphorbia antiquorum L. growing in Vietnam led to the isolation of five ent-atisanes, one seco-ent-atisane, and one lathyrane (ingol-type). The structures were elucidated as ent-1α,3α,16β,17-tetrahydroxyatisane (1), ethyl ent-3,4-seco-4,16β,17-trihydroxyatisane-3-carboxylate (2), ent-atisane-3-oxo-16β,17-acetonide (3), ent-3α-acetoxy-16β,17-dihydroxyatisane (4), ent-16β,17-dihydroxyatisane-3-one (5), calliterpenone (6), and ingol 12-acetate (7). Their chemical st… Show more

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Cited by 18 publications
(19 citation statements)
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“…The mechanism of alpha-glucosidase inhibition by BM3 was determined using Lineweaver-Burk plots (Microsoft Excel 2010, Washington, USA), following methods reported in the literature ( Tran et al, 2021 ). Enzyme inhibition at the different BM3 concentrations was evaluated from the substrate.…”
Section: Methodsmentioning
confidence: 99%
“…The mechanism of alpha-glucosidase inhibition by BM3 was determined using Lineweaver-Burk plots (Microsoft Excel 2010, Washington, USA), following methods reported in the literature ( Tran et al, 2021 ). Enzyme inhibition at the different BM3 concentrations was evaluated from the substrate.…”
Section: Methodsmentioning
confidence: 99%
“…The enzymatic reaction was carried out at 37 • C for 20 min and stopped by adding 0. The mechanisms of inhibition of alpha-glucosidase by 8 and 11 were determined by Lineweaver-Burk plots (Microsoft Excel 2010, Washington, WA, USA), using methods similar to those reported in the literature [28]. Enzyme inhibition due to various concentrations of the 8 and 11 compounds were evaluated by monitoring the effects of different concentrations of the substrate.…”
Section: Alpha-glucosidase Inhibition Assaymentioning
confidence: 99%
“…The literature data regarding the mechanism of α-glucosidase inhibition for diterpenes is scarce. The majority of reported compounds are non-competitive inhibitors, e.g., ent-atisane-3-oxo-16β,17-acetonide [ 39 ], (E)-labda-8(17),12-diene-15,16-dial [ 40 ], ent-kaurane derivative of chepraecoxin A [ 41 ], and bis-labdanic diterpene were reported as mixed-type inhibitors [ 42 ]. Notably, these inhibitors share an alicyclic core.…”
Section: Resultsmentioning
confidence: 99%