Alpha-human atrial natriuretic polypeptide (Alpha-hANP) in normal volunteers and patients with heart failure or hypertension

Tang, Jian; Song, D.L.; Suen, Mengfan; Xie, Cui-Wei; Chang, Ding; Chang, Jaw Kang

doi:10.1016/0196-9781(86)90057-4

Cited by 19 publications

(2 citation statements)

References 7 publications

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“…Perhaps the first study demonstrating that the PVN was involved in the pathogenesis of CHF was performed by Patel et al who showed that metabolic activity with the parvocellular and magnocellular regions of the PVN was increased in ischemia-induced CHF models [57]. In fact, a number of neuroactive peptides have been shown to be elevated in CHF including ANG, adrenomedullin, atrial natriuretic peptide, aldosterone and pro-inflammatory cytokines all of which have documented actions within the PVN [58][59][60][61][62][63]. ANG levels known to be elevated in CHF act within the PVN to increase renal sympathetic nerve activity (RSNA), increased renin release, and ultimately increased peripheral ANG release [64].…”

Section: Pathophysiological Consequences Of Pvn Dysfunctionmentioning

confidence: 99%

The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction

Ferguson

Latchford

Samson

2008

Expert Opinion on Therapeutic Targets

271

178

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Background-The paraventricular nucleus of the hypothalamus (PVN) has emerged as one of the most important autonomic control centers in the brain, with neurons playing essential roles in controlling stress, metabolism, growth, reproduction, immune, and other more traditional autonomic functions (gastrointestinal, renal and cardiovascular).Objectives-Traditionally the PVN was viewed very much as a nucleus in which afferent inputs from other regions were faithfully translated into changes in single specific outputs whether those were neuroendocrine or autonomic. Here we will present data which suggest that PVN in fact plays significant and essential roles in integrating multiple sources of afferent input and sculpting an integrated autonomic output by concurrently modifying the excitability of multiple output pathways. In addition we will highlight recent work which suggests that dysfunction of such intranuclear integrative circuitry may contribute to the pathology of conditions such as hypertension and congestive heart failure.Conclusions-This review highlights data showing that individual afferent inputs (SFO), signaling molecules (orexins, adiponectin), and interneurons (glutamate/GABA), all have the potential to influence (and thus coordinate) multiple PVN output pathways. We also highlight recent studies showing that modifications in this integrated circuitry may play significant roles in the pathology of diseases such as congestive heart failure and hypertension.

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Section: Pathophysiological Consequences Of Pvn Dysfunctionmentioning

confidence: 99%

The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction

Ferguson

Latchford

Samson

2008

Expert Opinion on Therapeutic Targets

271

178

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“…These antibodies were produced by conjugating each respective peptide to thyroglobulin with subsequent subcutaneous injection into rabbits. 10 Purity of Pro-ANF Peptides 1-30, 31-67, and To test these peptides for purity, we subjected them to reverse-phase high-pressure liquid chromatography using a Novapak C-18 (5 g) cartridge column. The Waters Associates liquid chromatograph was comprised of a Model 680 gradient controller, two Model 510 high-pressure liquid chromatography pumps, a Model U6K injector, and a Model 481 LC spectrophotometer.…”

Section: Patientsmentioning

confidence: 99%

The N-terminus and a 4,000-MW peptide from the midportion of the N-terminus of the atrial natriuretic factor prohormone each circulate in humans and increase in congestive heart failure.

Winters¹,

Sallman²,

Baker³

et al. 1989

Circulation

174

141

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Two peptides consisting of amino acids 1-30 and 31-67 of the N-terminus of the prohormone of atrial natriuretic factor (pro-ANF) that have vasodilatory and natriuretic properties were investigated to determine if they circulate in humans. Specific and sensitive radioimmunoassays were developed to amino acids 1-30, 31-67, and 99-126 of pro-ANF. Evaluation of human plasma that had been subjected to reverse-phase high-pressure liquid chromatography suggested that pro-ANFs 1-30 and 31-67 as well as ANF were distinct peaks in human plasma corresponding exactly to pure synthetic peaks of these peptides on high-pressure liquid chromatography. Molecular weight determination of the endogenous immunoreactive peptides measured in plasma by G-50 Sephadex gel permeation chromatography revealed that the pro-ANF 1-30 radioimmunoassay recognized a peptide of 10,000 MW, which is consistent with it measuring the whole N-terminus of pro-ANF (amino acids 1-98) but without ANF (C-terminus) attached to it. The pro-ANF 31-67 radioimmunoassay recognized mainly (more than 95%) a peptide of 3,900-4,000 MW, which corresponds closely with its actual molecular weight of 3,878. Our ANF radioimmunoassay recognizes a peptide in plasma of 3,000 MW with the known molecular weight of ANF being 3,081. The mean circulating concentrations of immunoreactive pro-ANF 1-98, pro-ANF 31-67, and ANF in 54 control subjects were 531±25, 371±+18, and 22±1 fmol/ml (±SEM), respectively. Thirty patients with varying severity of congestive heart failure were also studied. The N-terminus, C-terminus, and pro-ANF 31-67 increased: twofold for New York Heart Association functional Class II, threefold to ninefold for Class III, and 10-to 20-fold for Class IV patients with congestive heart failure. Thus, the N-terminus and a 4,000-MW peptide from the midportion of the N-terminus of pro-ANF as well as ANF circulate normally and increase proportionately to the increasing severity of congestive heart failure. However, because the pro-ANF 31-67 radioimmunoassay was the only assay that discriminated between patients with Class I congestive heart failure and control subjects, this assay may be the most useful to accurately classify the severity of congestive heart failure.

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Peptides and Opiates in Copper Deficiency

Bhathena

Recant²

1987

Biology of Copper Complexes

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Alpha-human atrial natriuretic polypeptide (Alpha-hANP) in normal volunteers and patients with heart failure or hypertension

Cited by 19 publications

References 7 publications

The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction

The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction

The N-terminus and a 4,000-MW peptide from the midportion of the N-terminus of the atrial natriuretic factor prohormone each circulate in humans and increase in congestive heart failure.

Peptides and Opiates in Copper Deficiency

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