Alpha interferon for hepatitis C virus infection in haemophilic patients

Telfer, Paul; Devereux, Helen; Colvin, B. T.; Hayden, Sheila; Dusheiko, Geoffrey; Lee, Christine

doi:10.1111/j.1365-2516.1995.tb00040.x

Cited by 33 publications

(23 citation statements)

References 20 publications

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“…The natural clearance rate of 17.4% is similar to that observed in non-haemophilia cohorts, the slightly lower level possibly reflects the preponderance of males in our study [4]. Previous data report lower rates of SVR for monotherapy in PWH compared with other HCV-infected groups [16][17][18][19] and our SVR (14.5%) is consistent with this. Combination therapy with interferon-alpha and ribavirin produces higher SVR in the non-haemophilia population with levels of 55% using pegylated interferon-alpha and ribavirin [20].…”

Section: Discussionsupporting

confidence: 90%

Hepatitis C infection and outcomes in the Scottish haemophilia population

et al. 2013

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Patients with bleeding disorders previously frequently became infected with hepatitis C virus. We identified the number of patients infected in Scotland and assessed several aspects of the outcomes of HCV infection and its treatment comparing these with cohorts infected for other reasons. We calculated the number of individuals infected in Scotland (cohort A) starting with the total number of patients treated in Scottish haemophilia centres registered on the UKHCDO database between 1970 and 1989. Cases were then removed or added based on additional information from centre records. A second cohort B, consisted of 255 patients from cohort A and 47 patients HCV infected outside Scotland, but with follow-up data from Scottish centres around their HCV infection. We estimate that 455 patients with bleeding disorders became infected by coagulation factor provided by NHS Scotland. In 302 individuals with documented HCV infection, rates of natural clearance (17.4%), genotype spread (64% genotype 1) and responses to antiviral therapy (14.5% with monotherapy; 38.8% with combination therapy) were similar to those in other cohorts. Thirty-four liver biopsies were performed without adverse event and liver transplantation has been performed in 11 patients, seven for liver failure, four for hepatocellular carcinoma. Around 455 patients with bleeding disorders became HCV infected in Scotland before 1989. The natural history of HCV infection and responses to treatment are similar to those in other HCV-infected cohorts. Liver transplantation has been used successfully for the treatment of end-stage liver failure and hepatocellular carcinoma.

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Section: Discussionsupporting

confidence: 90%

Hepatitis C infection and outcomes in the Scottish haemophilia population

et al. 2013

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“…Two patients received alpha interferon from 1987 and have previously been reported 7. Alpha interferon alone was used in 53 treatment episodes, including five patients who were treated twice and one who received three courses of therapy 8. We participated in a double blind controlled trial of ribavirin versus placebo in 12 patients in 1992 and subsequently continued open label therapy in two individuals 9.…”

Section: Methodsmentioning

confidence: 99%

The natural history of HCV in a cohort of haemophilic patients infected between 1961 and 1985

Yee¹,

Griffioen²,

Sabin³

et al. 2000

Gut

168

165

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“…HIV coinfection is associated with more severe histological appearances suggesting that HIV accelerates progression of HCVrelated liver disease in haemophiliacs (Eyster et al, 1993;Telfer et al, 1994). The most recent studies suggest the overall sustained response rate is very low (Telfer et al, 1995;Hanley et al, 1996). Close surveillance of this group is required, and the most appropriate treatment options, including liver transplantation, should be based on the circumstances of each individual.…”

Section: Discussionmentioning

confidence: 99%

Investigation of chronic hepatitis C infection in individuals with haemophilia: assessment of invasive and non‐invasive methods

Hanley

Jarvis²,

Andrews

et al. 1996

Br J Haematol

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Hepatitis C virus (HCV) infection is the major cause of chronic liver disease in individuals with haemophilia. A wide spectrum of disease severity is found in this group, ranging from mild hepatitis to cirrhosis. We have studied a cohort of 87 anti-HCV positive haemophiliacs who have been infected with HCV for 10-25 years and assessed the relative value of invasive and non-invasive methods of evaluating liver disease. The severity of liver disease was assessed using ultrasound scan (n = 77), upper GI endoscopy (n = 50), laparoscopic liver inspection (n = 33) and liver biopsy (n = 22). Invasive investigations were performed without any significant bleeding complications. Evidence of severe liver disease was found in approximately 25% of patients. There was agreement between the severity of liver histology and the information derived from the laparoscopic liver inspection, endoscopy and ultrasound in 86%. Co-infection with HIV was significantly associated with more severe liver disease (P = 0.006). This study provides further evidence that liver disease is emerging as a major complication in haemophiliacs and severe liver disease is more common in those co-infected with HIV. We have shown the potential value of laparoscopic liver inspection, in combination with endoscopy and ultrasound, in staging the extent of liver disease, and suggest that most patients may be managed without resorting to liver biopsy.

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Alpha interferon for hepatitis C virus infection in haemophilic patients

Cited by 33 publications

References 20 publications

Hepatitis C infection and outcomes in the Scottish haemophilia population

Hepatitis C infection and outcomes in the Scottish haemophilia population

The natural history of HCV in a cohort of haemophilic patients infected between 1961 and 1985

Investigation of chronic hepatitis C infection in individuals with haemophilia: assessment of invasive and non‐invasive methods

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