Alpha-ketoglutaric acid production using electrodialysis with bipolar membrane

Szczygiełda, Mateusz; Prochaska, Krystyna

doi:10.1016/j.memsci.2017.04.059

Cited by 66 publications

(8 citation statements)

References 33 publications

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“…The regenerated acids from BMED usually have a low concentration and purity and cannot be appropriately reused. Regarding the conversion of organic or amino acid by BMED, many experimental‐scale studies exist in the literature for citric acid, 18 salicylic acid, 19 formic acid, 20 niacin, 21 alpha‐ketoglutaric acid, 22 succinic acid, 23 and aldonic acid, 24 and some studies have examined batch‐scale or even pilot‐scale production of gluconic acid, 25 malic acid, 26 and methionine 27 . However, previous studies have mainly focused on the conversion of single or both organic/amino acids, but detailed studies of more than two organic/amino acids with different numbers of methylated groups has never been conducted.…”

Section: Introductionmentioning

confidence: 99%

Bipolar membrane electrodialysis for cleaner production of N‐methylated glycine derivative amino acids

Wang

Yan

et al. 2020

AIChE Journal

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In this study, cleaner production of N-methylglycine (NMG), N,N-dimethylglycine (DMG), and N,N,N-trimethylglycine (TMG) with similar structures but different methylate groups was performed using bipolar membrane electrodialysis (BMED). The effects of the feed mass concentration and current density on the separation performance were intensively analysed in terms of the molecular size, molecular structure, ion concentration, and interaction between amino acids and membranes. The results indicated that the optimal recovery performance was achieved at a current density of 200 A/m 2 and feed mass concentration of 6%. Under the optimal conditions, the energy consumption and current efficiencies were 2.3 kWh/kg and 78% for NMG, 2.49 kWh/kg and 69.5% for DMG, and 3.52 kWh/kg and 39.6% for TMG, respectively. It was speculated a competition for water splitting occurs between the bipolar membranes and anion exchange membranes when BMED is used for the separation and purification of large-sized bioproducts.

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Section: Introductionmentioning

confidence: 99%

Bipolar membrane electrodialysis for cleaner production of N‐methylated glycine derivative amino acids

Wang

Yan

et al. 2020

AIChE Journal

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“…14,15 In addition to producing inorganic bases and acids, the BMED technique has been applied for the production of organic acids, such as nicotinic acid, 16 succinic acid, 17 and sebacic acid or α-ketoglutaric acid. 18 As mentioned above, the feasibility of the BMED technique for inorganic acid production has been proven, with acceptable unit energy consumptions and current efficiencies. However, as far as we know, there has been no report regarding the effect of operating conditions on sodium ion leakage during the production of H 3 PO 2 in BMED.…”

Section: Introductionmentioning

confidence: 92%

“…Driven by direct current across the membrane stack, the water molecules in the intermediate layer of the bipolar membrane (BP) are dissociated into OH – and H + . Combined with anion-exchange membranes and cation-exchange membranes, the BMED system can convert salts in situ into corresponding acids and bases production. , Hence, the BMED technique has a wide range of applications in the fields of chemical industry, food processing, hypersaline wastewater treatment, resource recovery, and fermentation engineering. − The BMED technology has also been used to produce inorganic acids and bases from salts, such as Na 3 PO 4 , NaCl, NH 4 Cl, NaNO 3 , NaBr, and Na 2 SO 4 . , In addition to producing inorganic bases and acids, the BMED technique has been applied for the production of organic acids, such as nicotinic acid, succinic acid, and sebacic acid or α-ketoglutaric acid . As mentioned above, the feasibility of the BMED technique for inorganic acid production has been proven, with acceptable unit energy consumptions and current efficiencies.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Hypophosphorous Acid by Bipolar Membrane Electrodialysis: Process Optimization and Phosphorous Acid Minimization

Yan

Hang

Liu

et al. 2019

Ind. Eng. Chem. Res.

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Hypophosphorous acid (H3PO2) is an important chemical product with wide applications in pharmaceuticals and electroless plating. In this study, bipolar membrane electrodialysis (BMED) was used to produce H3PO2 from sodium hypophosphite salt (NaH2PO2) to replace the traditional preparation methods. The BMED process was optimized in terms of current density, NaH2PO2 salt concentration, and initial NaOH concentration of the base solution. The results indicated that low Na+ leakage occurred at lower salt concentrations. Under the optimum conditions, such a BMED system obtained a high concentration of H3PO2, a low Na+ content, and a low energy consumption, equaling to 1.03 mol/L, 670 ppm, and 1.18 kW h/kg, respectively. To minimize the amount of phosphorous acid (H3PO3) generated from H3PO2 oxidation during the BMED process, a nitrogen aeration operation was applied in both the acid and salt chambers, decreasing the HPO3 2– content to 251 ppm, which was 44.1% lower than that without a dissolved oxygen content control strategy. The newly produced H3PO3 during the BMED process was reduced by 96.5%. The obtained results indicated that the BMED process has great potential for application in the production of high-quality H3PO2 from NaH2PO2 in industry.

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“…In addition, electrodialysis has been regarded as a promising method in recent years, as it is efficient, wasteless and environment‐friendly. It has been widely applied for the separation of carboxylic acids . But the main shortcoming of the membrane electrodialysis process is its high energy consumption.…”

Section: Introductionmentioning

confidence: 99%

“…It has been widely applied for the separation of carboxylic acids. [16][17][18][19] But the main shortcoming of the membrane electrodialysis process is its high energy consumption. Although such methods have been reported to separate KGA or PYR, there have been few studies that focused on separating KGA and PYR simultaneously and completely.…”

mentioning

confidence: 99%

Separation of α‐ketoglutaric acid and pyruvic acid from the culture broth of Yarrowia lipolytica WSH‐Z06 by chromatographic methods

Peng

Zeng

et al. 2018

Biotechnology Progress

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Both α‐ketoglutaric acid (KGA) and pyruvic acid (PYR) are important keto acids. Efficient co‐production of KGA and PYR has been achieved in our previous work, and could significantly decrease the cost of fermentation production. KGA and PYR have similar physical and chemical properties. Hence, finding a way to separate the two keto acids efficiently has become a key challenge. In this study, different chromatographic methods have been investigated, including ion‐exchange chromatography, aluminum oxide chromatography and silica gel chromatography. The results show that the two keto acids can be well separated with silica gel chromatography, whereas ion‐exchange chromatography and aluminum oxide chromatography could not separate them. Using the pretreated fermentation broth of Yarrowia lipolytica WSH‐Z06, the purity and yield of KGA/PYR reached 98.7%/99.1% and 86.7%/70.9%, respectively, with an optimized silica gel chromatography‐based procedure. This study provides an efficient method for separating KGA and PYR from fermentation broth, which might be applied on an industrial scale and significantly decrease the cost of biotechnological production of keto acids. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 34:1370–1379, 2018

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Alpha-ketoglutaric acid production using electrodialysis with bipolar membrane

Cited by 66 publications

References 33 publications

Bipolar membrane electrodialysis for cleaner production of N‐methylated glycine derivative amino acids

Bipolar membrane electrodialysis for cleaner production of N‐methylated glycine derivative amino acids

Preparation of Hypophosphorous Acid by Bipolar Membrane Electrodialysis: Process Optimization and Phosphorous Acid Minimization

Separation of α‐ketoglutaric acid and pyruvic acid from the culture broth of Yarrowia lipolytica WSH‐Z06 by chromatographic methods

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