Alpha-l-fucosidase as a tumour marker of hepatocellular carcinoma

Montaser, Mohamed; Sakr, Mohamed A.; Khalifa, Mohamed

doi:10.1016/j.ajg.2012.03.006

Cited by 44 publications

(52 citation statements)

References 15 publications

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“…We did not find any studies analyzing FUC, GAL, MAN, and GLU activity in children with renal disease. On the other hand, alterations in the activity of FUC, GAL, MAN, and GLU enzymes have been described in different human malignancies [17, 19, 38–40]. In addition, some studies have reported that α-mannosidase activity might be a useful marker of Chlamydia trachomatis in urogenital tract specimens [41].…”

Section: Discussionmentioning

confidence: 99%

“…Increased activity of HEX in urine has been found because of heavy metal intoxication [9], nephrotoxic drugs [10], fever [11], nephritis [12], hypertension [13], diabetes [14], neoplasms [15], and during renal graft rejection [16]. Other lysosomal exoglycosidase activity, i.e., α-fucosidase (FUC), β-galactosidase (GAL), α-mannosidase (MAN), and β-glucuronidase (GLU), have been evaluated in numerous physiopathological situations such as hepatocellular carcinoma (HCC), liver disease, and gastric tumors, alcohol dependence, and colon and larynx cancers [17–22], but not in kidney diseases in children.…”

Section: Introductionmentioning

confidence: 99%

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New tubular injury markers in children with a solitary functioning kidney

et al. 2014

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BackgroundThe present study aimed to assess whether the urinary profiles of the lysosomal exoglycosidases N‑acetyl‑β‑hexosaminidase (HEX) and its isoenzymes A (HEX A) and B (HEX B), α-fucosidase (FUC), β-galactosidase (GAL), α-mannosidase (MAN), and β- glucuronidase (GLU) are useful biomarkers of tubular dysfunction in children with a solitary functioning kidney (SFK).MethodsWe measured the urinary activity of HEX, its isoenzymes HEX A, HEX B, and FUC, GAL, MAN, and GLU in 52 patients with SFK. Patients were subdivided into two groups: congenital SFK (cSFK)—unilateral renal agenesis and acquired SFK (aSFK)—unilateral nephrectomy. The reference group (RG) contained 60 healthy sex- and age-matched children.ResultsUrinary activity of all exoglycosidases in SFK was significantly higher than in RG (p < 0.05). There were no differences in exoglycosidase activity between cSFK and aSFK (p > 0.05). HEX and its isoenzymes HEX A and HEX B correlated negatively with estimated glomerular filtration rate (eGFR), and all estimated parameters correlated positively with albumin/creatinine ratio (p < 0.001).ConclusionUrinary activity of HEX, its isoenzymes HEX A and HEX B, and FUC, GAL, MAN, and GLU is elevated in children with SFK. Long-term follow-up studies in larger groups of children with SFK may help us to better understand their clinical significance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New tubular injury markers in children with a solitary functioning kidney

et al. 2014

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“…It has been reported that the sensitivity, specificity and diagnostic accuracy of AFU at the cut-off value of 2.3005 μ mol/l/min were 90, 97.5 and 94.9%, respectively. The combined detection of AFP and AFU can improve the sensitivity, specificity and diagnostic accuracy of AFP from 70, 85 and 79.7%, respectively, to 95, 100 and 99.1%, respectively (46). In addition, AFU can reveal the case 6–9 months earlier than ultrasonographic visualization (47).…”

Section: Enzymes and Isozymesmentioning

confidence: 99%

Tumor markers for hepatocellular carcinoma

Zhao¹,

Ju²,

Li³

2013

Molecular and Clinical Oncology

231

180

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a high rate of morbidity and mortality. HCC affects approximately one million individuals annually worldwide, with the incidence equal to the mortality rate. In 2008, HCC was listed as the third most lethal cancer. Thus, early diagnosis is crucial for improving the survival rate for patients. α-fetoprotein (AFP) together with iconography and pathology detection are commonly used in the clinical early diagnosis of liver cancer. However, the specificity and sensitivity of AFP used in screening for liver cancer are not satisfactory. Athough the development of molecular biology has led to the identification of new tumor markers, including proteantigens, cytokines, enzymes and isoenzymes, as well as related genes that can be used in the treatment and prognosis of liver cancer, more tumor markers are required for effective early diagnosis of diseases and monitoring of the curative effect.

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“…Its serum levels have been shown to increase in patients with cirrhosis and HCC [45] . At a threshold of 2.3005 µmol/L per minute, AFU yielded a sensitivity and specificity of 90% and 97.5%, respectively [46] .…”

Section: Alpha-l-fucosidasementioning

confidence: 99%

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Khattab

Fouad

Ahmed

2015

WJH

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The prevalence of hepatocellular carcinoma (HCC) has progressively increased in recent years and is now the fifth and the second most common cancer in the World and in Egypt, respectively. Much work has focused in the development of assays for detecting hepatic carcinogensis before the observance of hepatic focal lesions. Particular attention has been directed towards HCC-specific biomarkers for use in the early diagnosis of HCC and in the confirmation of radiological studies. Although a number of biomarkers have been identified, none have been considered reliable indicators of early HCC lesions. This review presents a few of the most relevant HCC biomarkers and suggests improvements to the accuracy of diagnostic assays through their combined use. Furthermore, we present an algorithm for the biomarker-based diagnosis of HCC and highlight its important role in the early prediction of HCC. Core tip: Alpha-fetoprotein (AFP) has been widely used as a reference biomarker to validate the diagnosis of hepatocellular carcinoma (HCC). However, normal physiological-levels of AFP are observed in approximately one third of HCC cases. Furthermore, a number of HCC positive patients have AFP levels less than the threshold value of 400 ng/mL. These factors make an AFP-based diagnosis of HCC far from reliable. However, high diagnostic accuracy indices have been reported when AFP is combined with other biomarkers such as midkine, golgi protein 73, des-γ-carboxyprothrombin, glypican-3, and gamma-glutamyl transferase.Khattab M, Fouad M, Ahmed E. Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma. World J Hepatol 2015; 7(23): 24742481 Available from:

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Alpha-l-fucosidase as a tumour marker of hepatocellular carcinoma

Cited by 44 publications

References 15 publications

New tubular injury markers in children with a solitary functioning kidney

New tubular injury markers in children with a solitary functioning kidney

Tumor markers for hepatocellular carcinoma

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

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