Alpha-linolenic acid: A promising nutraceutical for the prevention of stroke

Nguemeni, Carine; Gouix, Elsa; Bourourou, Miled; Heurteaux, Catherine; Blondeau, Nicolas

doi:10.1016/j.phanu.2012.12.002

Cited by 48 publications

(28 citation statements)

References 53 publications

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“…The predominant v-6 and v-3 found in most seed oils are C18 FAs including linoleic acid (LA 18:2 D-9,12) and a-linoleic acid (ALA C18:3 D-9,12,15) [1]. These are associated with prevention of vision and brain function impairments, as well as stroke occurrence [20]. The conversion of native plant FAs such as LA and ALA to VLC-PUFA requires several FA elongases and desaturases that are not present in higher plants [21].…”

Section: Bioengineered Plantsmentioning

confidence: 99%

Towards sustainable sources for omega-3 fatty acids production

Adarme-Vega

Thomas‐Hall

Schenk

2014

Current Opinion in Biotechnology

203

111

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Section: Bioengineered Plantsmentioning

confidence: 99%

Towards sustainable sources for omega-3 fatty acids production

Adarme-Vega

Thomas‐Hall

Schenk

2014

Current Opinion in Biotechnology

203

111

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“…On the other hand, alpha-linolenic acid per se exhibited a wide range of neuronal protection. In a recent review, Nguemeni et al (2013) recommended alpha-linolenic acid for preventing stroke. This recommendation was based on the effects of the acid on neurogenesis and synaptogenesis processes (Fig.…”

Section: Discussionmentioning

confidence: 99%

Fatty acids rehabilitated long-term neurodegenerative: like symptoms in olfactory bulbectomized rats

Yehuda

Rabinovitz

2014

J Neural Transm

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Our previous study demonstrated that an olfactory bulbectomy in rats induced short-term, multifaceted, devastating Alzheimer's-like effects, which included cognitive impairment, hyperactivity, hyperthermia, and increased levels of homocysteine and pro-inflammatory cytokines, including IL-17A. In addition, the rats exhibited an increase in the hyperphosphorylation of brain Tau proteins and in the number of neurofibrillary tangles. Here, we examined the long-term effects of the surgery and found that olfactory bulbectomy also rendered the rats to become anemic with brain iron overload. Additionally, a significant reduction in the membrane fluidity index in frontal cortex synaptosomes was found. Treatment with a mixture of n - 3/n - 6 of fatty acids restored the unwanted effect. The beneficial effects of fatty acids are mediated via the effects of fatty acids on the neuronal membrane structure and fluidity. These findings are similar to Alzheimer's symptoms, which suggest this model can be used as an animal model for Alzheimer's disease. We recommend using this model to scan potential new anti-Alzheimer's drugs.

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“…[18,19,31]). It is important to note that beneficial effects of LC-omega-3 enriched diets were mainly observed when comparing with diets lacking EPA/DHA.…”

Section: Omega-3 Supplementation To Lower Stroke Risk: Origin Of the mentioning

confidence: 99%

“…In addition, several studies investigating the importance of dietary omega-3 PUFAs, achieved by consumption of seafood (rich in LC-n-3: EPA and DHA) and/or vegetable oils rich in precursor (ALA), proposed omega-3 PUFAs as key support for neurons and brain resistance (for review, see Refs. [18,19]. Therefore, nutritional products with health benefits or supplemented with such protective nutrients seem promising for reducing the incidence of stroke, encouraging the discovery or characterization of an efficient nutraceutical targeted against stroke.…”

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confidence: 99%

The nutraceutical potential of omega-3 alpha-linolenic acid in reducing the consequences of stroke

Blondeau

2016

Biochimie

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Stroke is a worldwide major cause of mortality and morbidity. Preclinical studies have identified over 1000 molecules with brain-protective properties. More than 200 clinical trials have evaluated neuroprotective candidates for ischemic stroke yet, to date almost all failed, leading to a re-analysis of treatment strategies against stroke. An emerging view is to seek combinatory therapy, or discovering molecules able to stimulate multiple protective and regenerative mechanisms. A pertinent experimental approach to identify such candidates is the study of brain preconditioning, which refers to how the brain protects itself against ischemia and others stress-inducing stimuli. The recent discovery that nutrients like alpha-linolenic acid (ALA is an essential omega-3 polyunsaturated fatty acid required as part of our daily diet), may be an efficient brain preconditionner against stroke fosters the novel concept of brain preconditioning by nutraceuticals. This review stresses the underestimated role of nutrition in preventing and combating stroke. Although there is a consensus that increased consumption of salt, fatty foods and alcoholic beverages may promote pathologies like hypertension, obesity and alcoholism - all of which are well known risk factors of stroke - few risk factors are attributed to a deficiency in an essential nutrient in the diet. The ALA deficiency observed in the Western modern diets may itself constitute a risk factor. This review outlines how ALA supplementation by modification of the daily diet prevented mortality and cerebral damage in a rodent model of ischemic stroke. It also describes the pleiotropic ability of ALA to trigger responses that are multicellular, mechanistically diverse, resulting in neuronal protection, stimulation of neuroplasticity, and brain artery vasodilation. Overall, this review proposes a promising therapeutic opportunity by integrating a nutritional-based approach focusing on enriching the daily diet in ALA to prevent the devastating damage caused by stroke.

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Alpha-linolenic acid: A promising nutraceutical for the prevention of stroke

Cited by 48 publications

References 53 publications

Towards sustainable sources for omega-3 fatty acids production

Towards sustainable sources for omega-3 fatty acids production

Fatty acids rehabilitated long-term neurodegenerative: like symptoms in olfactory bulbectomized rats

The nutraceutical potential of omega-3 alpha-linolenic acid in reducing the consequences of stroke

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