Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice

Ardianto, Chrismawan; Wardani, Hijrawati Ayu; Nurrahmi, Nurrahmi; Rahmadi, Mahardian; Khotib, Junaidi

doi:10.14202/vetworld.2020.963-966

Cited by 9 publications

(6 citation statements)

References 14 publications

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“…In experimental studies, SV has been reported to elevate liver marker enzymes in serum and induce oxidative stress mediated liver injury in rats 10,11 . Therefore, SV has been used as a hepatotoxic model to evaluate the hepatoprotective efficacy of several antioxidants such as ellagic acid, 10 curcumin, N ‐acetylcysteine, 12 melatonin, 13 ginsenoside compound K 14 and alpha‐lipoic acid 15 and showed promising results. These studies have shown that antioxidants could regress the oxidative stress inducing potential of SV in experimental animals.…”

Section: Introductionmentioning

confidence: 99%

Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

Gheena

Ezhilarasan

Harini

et al. 2022

Environmental Toxicology

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Sodium valproate (SV) is a well‐known anti‐epileptic drug, also used to control convulsions, bipolar disorders and migraines. SV has been shown to induce liver toxicity in clinical subjects. Syringic acid (SA), a natural polyphenolic compound has potential antioxidant, anti‐inflammatory and several beneficial effects. Therefore, in this study, we evaluated hepatoprotective effect of SA against SV‐induced liver injury in rats. Wistar rats were treated with SV orally at a dose of 500 mg/kg, once daily, for 14 days. Another three groups of rats were administered with SV and concurrently treated with SA (40 and 80 mg/kg) and silymarin (SIL) (100 mg/kg) for 14 days. SV administration for 14 days caused significant (p < .001) elevation of liver transaminases and ALP in serum. Liver MDA level was significantly (p < .001) increased with a concomitant decrease (p < .001) in enzymic antioxidants activities in SV administered rats. SV administration also caused the upregulation of proinflammatory markers such as tumor necrosis factor α, c‐Jun N‐terminal kinase, nuclear factor kappa B, cyclooxygenase‐2 and Interleukin 6 expressions in liver tissue. Histopathological studies also revealed the presence of inflammatory cell infiltration and hepatocellular necrosis upon SV administration. At both doses, concurrent administration of SA and SIL significantly (p < .001) inhibited the liver transaminase activities in serum, oxidative stress, and proinflammatory markers expression in liver tissue. Our current results suggest that SA can be a promising herbal drug that can inhibit SV‐induced hepatotoxicity when administered together due its potential anti‐inflammatory effects.

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Section: Introductionmentioning

confidence: 99%

Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

Gheena

Ezhilarasan

Harini

et al. 2022

Environmental Toxicology

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“…Epilepsy is one of the most common neurological disorders worldwide, and approximately 90% of patients with epilepsy live in developing regions [25]. Antiepileptic drugs (AEDs) used in the treatment of epilepsy are widely used by patients [26].…”

Section: Discussionmentioning

confidence: 99%

“…VPA is an AED used to treat various seizure disorders. However, serious side effects such as hepatotoxicity, pancreatitis, thrombocytopenia, and platelet aggregation are associated with VPA treatment [25]. After treatment with VPA, changes may occur in the number and characteristics of T lymphocytes in the spleen, a central organ of the immune system [28].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats

AKARAS,

KANDEMİR,

ŞİMŞEK

et al. 2023

Türk Doğa Ve Fen Dergisi

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Aim: Long-term exposure to sodium valproate, an antiepileptic drug, causes toxic effects in tissues, especially by increasing oxidative stress and inflammation. Rutin is a flavanoid with antioxidant, anti-inflammatory and antiapoptotic effects found naturally in many plants. In this study, we aimed to investigate the effects of rutin, a natural antioxidant, on sodium valproate-induced spleen tissue damage. Materials and Methods: 35 male rats were divided into 5 groups as control, sodium valproate, rutin, sodium valproate+Rutin 50 and sodium valproate+Rutin 100 groups. For 14 days, 500 mg/kg dose of sodium valproate and 50 or 100 mg/kg of rutin were administered by oral gavage. On day 15, spleen tissues were removed and biochemical methods, oxidative stress, inflammation and apoptotic parameters were analyzed and histologic analysis was performed. Results: The levels of sodium valproate-induced oxidative stress, inflammation and apoptosis parameters increased in spleen tissues compared to the control group (p

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“…Common adverse reactions include diarrhea, dyspepsia, nausea, vomiting, gastrointestinal spasm and menstrual cycle changes. Long-term use may cause pancreatitis and acute liver necrosis [47]. Its mechanism has not been fully clarified.…”

Section: Detection Of the Antiepileptic Drugs By The Ag 25 -C-fiber S...mentioning

confidence: 99%

Ag Nanoislands Modified Carbon Fiber Nanostructure: A Versatile and Ultrasensitive Surface-Enhanced Raman Scattering Platform for Antiepileptic Drug Detection

Shi

Han

et al. 2021

Coatings

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A high-efficiency surface-enhanced Raman scattering (SERS) detection method with ultra-high sensitivity has been widely applied in drug component detection to optimize the product quality verification standards. Herein, a controllable strategy of sputtering Ag nanoislands on carbon fiber (C-fiber) via magnetron sputtering technology was proposed to fabricate a versatile Ag-C-fiber SERS active substrate. A wide range of multi-level electromagnetic enhancement “hot spots” distributed on Ag-C-fiber nanostructures can efficiently amplify Raman signals and the experimental enhancement factor (EEF) value was 3.871 × 106. Furthermore, substantial “hot spots” of large-scale distribution guaranteed the superior reproducibility of Raman signal with relative standard deviation (RSD) values less than 12.97%. Limit of detection (LOD) results indicated that when crystal violet (CV) is employed as probe molecule, the LOD was located at 1 × 10−13 M. By virtue of ultra-sensitivity and good flexibility of the Ag-C-fiber nanotemplate, Raman signals of two kinds of antiepileptic drugs called levetiracetam and sodium valproate were successfully obtained using an SERS-based spectral method. The Ag-C-fiber SERS detection platform demonstrated a good linear response (R2 = 0.97486) in sensing sodium valproate concentrations in the range of 1 × 103 ng/μL−1–1 ng/μL. We believe that this reliable strategy has potential application for trace detection and rapid screening of antiepileptic drugs in the clinic.

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Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice

Cited by 9 publications

References 14 publications

Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats

Ag Nanoislands Modified Carbon Fiber Nanostructure: A Versatile and Ultrasensitive Surface-Enhanced Raman Scattering Platform for Antiepileptic Drug Detection

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