Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation

Abstract

AimExtracorporeal circulation (ECC) of blood during cardiopulmonary surgery has been shown to stimulate various pro-inflammatory molecules such as cytokines and chemokines. The biochemical oxidation/reduction pathways of a-lipoic acid suggest that it may have antioxidant properties.MethodsIn this study we aimed to evaluate only patients with coronary heart disease and those planned for coronary artery bypass graft operation. Blood samples were obtained from the patients before the operation (P1) and one (P2), four (P3), 24 (P4) and 48 hours (P5) after administration of a-lipoic acid (LA). The patients were divided into two groups, control and LA treatment group. Levels of interleukin-6 (IL-6) and -8 (IL-8), complement 3 (C3) and 4 (C4), anti-streptolysin (ASO), C-reactive protein (CRP) and haptoglobin were assessed in the blood samples.ResultsCytokine IL-6 and IL-8 levels were significantly higher after surgery. Compared with the control groups, LA significantly decreased IL-6 and IL-8 levels in a time-dependent manner. CRP levels did not show significant variation in the first three time periods. CRP levels were higher after surgery, especially in the later periods. These results demonstrate that CRP formation depends on cytokine release. C3 and C4 levels were significantly higher after surgery than in the pre-operative period. LA treatment decreased C3 and C4 levels. Therefore, LA administration may be useful for the treatment of diseases and processes where excessive cytokine release could cause oxidative damage.ConclusionsOur findings suggest a possible benefit of using LA during cardiac surgery to reduce cytokine levels.

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“…IL-6 concentration remains higher than preoperative one in 24 h after CABG. [19,20] Thus, we confirmed the results of the study according to which IL-6 increases during and just after the EC, which is caused by surgical injury, and decreases on the 3 rd -5 th days after the surgery but further remaining of its increased values is the evidence of significance of systemic inflammatory reaction [21] and can be used for prognosis of course of inpatient period. Authors consider at the high level of MMP-1 in the patients with coronary atherosclerosis is a risk factor of the onset and development of acute coronary syndrome, because MMP-1 contributes to injury to APs, where later clotting occurs.…”

The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model

“…Thioctic acid has known anti-inflammatory effects: 29,30 it significantly reduces interleukin-1b and TNF-a levels in experimental acute pancreatitis (in rats) and inhibits the increase in inducible NO synthase expression and activity in morphine-dependent rat brain. 31,32 These anti-inflammatory actions may be responsible for the antiallodynic effects of thioctic acid in neuropathy.…”

C1 inhibitor-mediated myocardial protection from chronic intermittent hypoxia-induced injury

“…In support of this hypothesis, studies have demonstrated that the localization/deposition of complement components (such as C1q, C3, C4 and C5) occurs in hypoxic myocardium (10)(11)(12)(13). Furthermore, mice deficient in C3, C5 or C6 have less severe I/R-induced myocardial injury compared with those of the wild-type (11).…”

“…Furthermore, mice deficient in C3, C5 or C6 have less severe I/R-induced myocardial injury compared with those of the wild-type (11). In addition, depletion (with cobra venom factor) or inhibition (with C1INH or soluble complement receptor 1) of complement activation attenuates cardiomyocyte injury during the hypoxia/reoxygenation process (12). C1INH has been demonstrated to block the classical complement pathway by binding to the activated C1 complex (C1q, C1s and C1r) (10), which results in dissociation of the complex.…”