.ALPHA.-Lipoic Acid Inhibits Melanogenesis in Three-dimensional Human Skin Model

Unno, Toshihiro; Ito, Fumihiro; Sagesaka, Yuko M.

doi:10.3136/fstr.15.537

Cited by 2 publications

(2 citation statements)

References 15 publications

(16 reference statements)

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“…It is also a cosmetic ingredient classified as an AOX 117 . Various studies have suggested applications in anti‐fibrosis, 171 wound healing, 172 skin lightening, 173 UV‐induced pigmentation control, 174 protection from skin damage induced by smoke, 175 as well as anti‐aging, 176,177 photoaging 178 and photoprotection, 179 although this is controversial 180 . Among its various mechanisms of action, lipoic acid is an Nrf2‐dependent inducer of phase II detoxification enzymes 181 .…”

Section: Research Strategy For Nrf2 Modulators In Skin and Scalp Carementioning

confidence: 99%

“…Carnosic acid and Carnosol -Keap1 Cys151 electrophilic addition of quinone metabolites 146 -Mild stress-induced hormesis 71 Anti-aging 71 Catechol flavonoid Eriodictyol Keap1 Cys151 electrophilic addition of quinone metabolites 146 -Photoprotection, antiphotoaging 147 -Atopy 147 -Skin depigmentation 147 -Skin photoprotection and antipollution 157,155 -Anti-hyperpigmentation 155 -Anti-blemish and skin lightening 157 -Wound healing 155,156 (Continues) 176,177 and photoaging 178 but controversial 180 -UV-induced pigmentation and epidermal thickening 174 -Protection from smoking-induced skin damage 175 -Wound healing 172 -Anti-pigmentation 173…”

Section: Catechol Abietane Diterpenesmentioning

confidence: 99%

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NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

2022

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The skin is the organ that is most susceptible to the impact of the exposome.Located at the interface with the external environment, it protects internal organs through the barrier function of the epidermis. It must adapt to the consequences of the harmful effects of solar radiation, the various chemical constituents of atmospheric pollution, and wounds associated with mechanical damage: oxidation, cytotoxicity, inflammation, and so forth. In this biological context, a capacity to adapt to the various stresses caused by the exposome is essential; otherwise, more or less serious conditions may develop accelerated aging, pigmentation disorders, atopy, psoriasis, and skin cancers. Nrf2-controlled pathways play a key role at this level. Nrf2 is a transcription factor that controls genes involved in oxidative stress protection and detoxification of chemicals. Its involvement in UV protection, reduction of inflammation in processes associated with healing, epidermal differentiation for barrier function, and hair regrowth, has been demonstrated. The modulation of Nrf2 in the skin may therefore constitute a skin protection or care strategy for certain dermatological stresses and disorders initiated or aggravated by the exposome. Nrf2 inducers can act through different

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Section: Research Strategy For Nrf2 Modulators In Skin and Scalp Carementioning

confidence: 99%

Section: Catechol Abietane Diterpenesmentioning

confidence: 99%

NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

2022

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Implications of Oxidative Stress in the Pathogenesis and Treatment of Hyperpigmentation Disorders

Xing

Dan

et al. 2022

Oxidative Medicine and Cellular Longevity

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Oxidative stress represents an imbalance between the generation of reactive oxygen and nitrogen species and the ability of antioxidant systems to decompose those products. Oxidative stress is implicated in the pathogenesis of hyperpigmentation, hypopigmentation, melanoma, and other skin diseases. Regulatory networks involving oxidative stress and related pathways are widely represented in hypopigmentation diseases, particularly vitiligo. However, there is no complete review into the role of oxidative stress in the pathogenesis of hyperpigmentation disorders, especially regarding associations involving oxidative stress and cellular signaling pathways. Here, we review oxidative and antioxidant systems, oxidative stress-induced signal transduction mechanisms, and effects of antioxidant drugs used in preclinical and clinical settings in hyperpigmentation disorders.

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.ALPHA.-Lipoic Acid Inhibits Melanogenesis in Three-dimensional Human Skin Model

Cited by 2 publications

References 15 publications

NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

Implications of Oxidative Stress in the Pathogenesis and Treatment of Hyperpigmentation Disorders

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