Alpha‐lipoic acid prevents brain injury in rats administered with valproic acid

Türkyılmaz, İsmet Burcu; Sökmen, Bahar Bilgin; Yanardağ, Refiye

doi:10.1002/jbt.22580

Cited by 15 publications

(9 citation statements)

References 52 publications

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“…These negative effects include toxicities on the liver, lens, kidney, brain, and gastrointestinal system. [ 1–5 ] This situation brings about a restriction on the usage of this drug. In addition to that, VPA is a short‐chained fatty acid.…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Türkyılmaz

Altaş

Arisan

et al. 2021

J Biochem & Molecular Tox

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Valproic acid (VPA) is an efficient antiepileptic drug widely used for the treatment of epilepsy and other seizures in both children and adults. It is also reported to have side and toxic effects on many organs and tissues. Vitamin B 6 (Vit B 6 ) is a welldescribed water-soluble vitamin, which has an antioxidant effect. In this study, we aimed to investigate the protective effect of Vit B 6 on VPA-induced brain injury.Male Sprague-Dawley rats were divided into four groups. Group I, control animals;Group II, Vit B 6 (50 mg/kg/day) given rats; Group III, VPA (500 mg/kg/day) given rats; Group IV, VPA and Vit B 6 given rats at same dose and time. VPA and Vit B 6 were administered intraperitoneally and orally, respectively, for 7 days. At the end of the experiments, the rats were sacrificed and brain tissues were taken. Protein carbonyl and sialic acid levels, xanthine oxidase, adenosine deaminase, acetylcholine esterase, lactate dehydrogenase, myeloperoxidase activities, total oxidant status, and reactive oxygen species levels were found to be increased, while glutathione and total antioxidant capacity levels, catalase, superoxide dismutase, glutathione-Stransferase, paraoxonase, and glutathione reductase activities were found to be decreased in the VPA group. Administration of Vit B 6 reversed these defects in the VPA group. These findings indicate that Vit B 6 has a protective effect on VPAinduced brain damage.

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Section: Introductionmentioning

confidence: 99%

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Türkyılmaz

Altaş

Arisan

et al. 2021

J Biochem & Molecular Tox

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“…As for glomerular histomorphometry, diabetic animals supplemented with ALA showed greater preservation in all of the parameters of glomerular areas when compared with the non-supplemented diabetic group. These results may be related to ALA's antioxidant action [47,48] and attenuation of chronic hyperglycemia [15,16], ensuring a protective effect on nephropathy and delaying glomerular lesions.…”

Section: Discussionmentioning

confidence: 99%

Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

et al. 2022

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Chronic hyperglycemia caused by diabetes results in systemic damage to the body, and the kidney ends up being the target of tissue damage. The use of antioxidants such as alpha-lipoic acid (ALA) has been shown to improve clinical and biochemical parameters in diabetic patients as they help in the prevention of oxidative stress. The present study aimed to undertake a comparative evaluation of the renal morphology of normal and diabetes-induced Wistar rats supplemented with ALA. The experiment had 4 experimental groups (n=7): a control group and a diabetic group that were fed commercial food; an alpha-lipoic group and an alpha-lipoic diabetic group that received the ALA supplement. Diabetes was induced with a single intraperitoneal injection of alloxane monohydrate administered after fasting. After 60 days of the experiment, the kidneys were excised to study the histomorphometric and stereological parameters of the glomeruli and renal tubules and the immunohistochemical parameters with a podocyte count. In the evaluation, the ALA promoted improvement in all of the relevant parameters of the glomerular areas and attenuation of tubular lesions of diabetic animals (p<0.001). Supplementation with ALA also showed beneficial effects in diabetic animals, such as reducing hyperglycemia and the damage promoted by oxidative stress alongside promoting a protective effect on the renal parenchyma. The reduction of glomerular and tubular damage delayed the advance of diabetic nephropathy and its complications, preventing renal failure in diabetic groups.

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“…The present outcomes are in accordance with the study of Faghir‐Ghanesefat et al [ 62 ] It was proven that sulfur‐containing compounds like alpha lipoic acid are capable of preventing the overproduction of NO in epileptic brain tissues. [ 63 ] Vit U reversed the altered NO levels in PTZ group probably via its antioxidant capacity.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of vitamin U on pentylenetetrazole‐induced brain damage in rats

Bayrak

Türkyılmaz

Yanardağ

2022

J Biochem & Molecular Tox

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Pentylenetetrazole (PTZ) is preferred for experimental epilepsy induction. PTZ damages brain and other organs by elevating oxidative substances. Vitamin U (Vit U) is sulfur derivative substance that proved to be an excellent antioxidant.The current study was intended to determine the protective role of Vit U on PTZ-induced brain damage. Male Sprague-Dawley rats were separated into four groups. The Control group (Group I), was given saline for 7 days intraperitoneally (i.p); Vit U (Group II) was given as 50 mg/kg/day for 7 days by gavage; PTZ was injected into animals (Group III) at a single dose of 60 mg/kg, by i.p; PTZ + Vit U group (Group IV) was administered PTZ and Vit U in same dose and time as aforementioned. After the experiment was terminated, brain tissues were taken for the preparation of homogenates. In the PTZ group, glutathione and lipid peroxidation levels, alkaline phosphatase, myeloperoxidase, xanthine oxidase, acetylcholine esterase, antioxidant enzyme activities, total oxidant status, oxidative stress index, reactive oxygen species, and nitric oxide levels were increased. However, total antioxidant capacity was decreased in the PTZ group.Vit U ameliorated these effects in the PTZ-induced brain damage. Consequently, we can suggest that Vit U protected brain tissue via its antioxidant feature against PTZ kindling epilepsy.

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Alpha‐lipoic acid prevents brain injury in rats administered with valproic acid

Cited by 15 publications

References 52 publications

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

The protective effect of vitamin U on pentylenetetrazole‐induced brain damage in rats

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Alpha‐lipoic acid prevents brain injury in rats administered with valproic acid

Cited by 15 publications

References 52 publications

Effect of vitamin B6on brain damage in valproic acid induced toxicity

Effect of vitamin B6on brain damage in valproic acid induced toxicity

Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

The protective effect of vitamin U on pentylenetetrazole‐induced brain damage in rats

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Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Effect of vitamin B₆on brain damage in valproic acid induced toxicity