Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice

Catorce, Miryam Nava; Acero, Gonzalo; Pedraza‐Chaverrí, José; Fragoso, Gladis; Govezensky, Tzipe; Gevorkian, Goar

doi:10.1016/j.jneuroim.2016.05.008

Cited by 47 publications

(43 citation statements)

References 50 publications

(60 reference statements)

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“…Neuroinflammation is key component in the pathogenesis and advancement of neurodegenerative disorders such as AD, PD, frontotemporal dementia, amyotrophic lateral sclerosis and multiple sclerosis [100][101][102]. Studies [101][102][103][104] have demonstrated that brains from patients with neurodegenerative disorders are depicted with distinct astrocytosis, stimulation of microglia and higher concentrations of proinflammatory cytokines.…”

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

“…Studies [101][102][103][104] have demonstrated that brains from patients with neurodegenerative disorders are depicted with distinct astrocytosis, stimulation of microglia and higher concentrations of proinflammatory cytokines. Further studies [101,105,106] have shown that peripheral injection of lipopolysaccharid (LPS) in mice triggers astrocyte and microglia stimulation as well as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS)…”

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

“…An in vitro study [107] revealed that α-MG suppresses IL-6 and IL-8 secretion in LPS-triggered human gingival fibroblasts. Nevertheless, studies [101,108] have proven that IL-6, which was secreted after peripheral immune experimentation, binds to its receptor on brain endothelial cells resulting in upsurge of COX-2 secretion as well as prostaglandin synthesis. Preclinical statistics and human analyses [101,109,110] revealed an imperative role of IL-6 in the pathogenesis of depression, mild traumatic brain injury (TBI) and brief hypoxia.…”

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

“…Nevertheless, studies [101,108] have proven that IL-6, which was secreted after peripheral immune experimentation, binds to its receptor on brain endothelial cells resulting in upsurge of COX-2 secretion as well as prostaglandin synthesis. Preclinical statistics and human analyses [101,109,110] revealed an imperative role of IL-6 in the pathogenesis of depression, mild traumatic brain injury (TBI) and brief hypoxia. Furthermore, studies [101,109] have proven that IL-6 is not merely a biomarker of TBI or neuroinflammation but, an intermediator of pathophysiology as well as a key influential factor during neuroinflammatory reaction.…”

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

“…Preclinical statistics and human analyses [101,109,110] revealed an imperative role of IL-6 in the pathogenesis of depression, mild traumatic brain injury (TBI) and brief hypoxia. Furthermore, studies [101,109] have proven that IL-6 is not merely a biomarker of TBI or neuroinflammation but, an intermediator of pathophysiology as well as a key influential factor during neuroinflammatory reaction. Correspondingly, a study [111] has shown that COX-2-catalyzed prostaglandin E2 (PGE2) stimulation IL-6 through p38 mitogen-activated kinase (p38 MAPK) and protein kinase C (PKC).…”

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

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The Pivotal Neuroinflammatory, Therapeutic and Neuroprotective Role of Alpha-Mangostin

Richard

Zheng

et al. 2017

J Neurol Res

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Alpha-mangostin (α-MG), one of the key xanthone derivatives, displays a multiplicity of curative qualities like antiinfective, anti-malarial, anticarcinogenic, antidiabetic actions as well as antioxidant properties. Furthermore, it has proven to have neuroprotective, hepatoprotective, and cardioprotective features, of which the anticarcinogenic action is the most auspicious. Additionally, several in vitro and in vivo analyses confirm that α-MG partakes in the major stages of tumor growth: initiation, promotion, and progression. Nevertheless, α-MG services as an inhibitory agent that modulate various enzymes involved in the metabolic activation and excretion of carcinogens, resistance to oxidative damage, and attenuation of inflammatory response. Numerous studies have also implicated α-MG in central nervous system (CNS) disorders, among which neuroinflammatory disorders and brain cancer are cardinal. Based on these initial studies on α-MG, we reviewed the pivotal role of α-MG in neuroinflammatory disorders.

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Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

Section: Neuroinflammatory Potentails Of α-Mgmentioning

confidence: 99%

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The Pivotal Neuroinflammatory, Therapeutic and Neuroprotective Role of Alpha-Mangostin

Richard

Zheng

et al. 2017

J Neurol Res

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Six New Polyoxygenated Xanthones from Garcinia cowa and Their Neuroprotective Effects on Glutamate‐Mediated Hippocampal Neuronal HT22 Cell Death

Tran

Nguyen

et al. 2022

Chemistry & Biodiversity

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Six new polyoxygenated xanthones, garcicowanones F -H (1-3), norcowanol A -B (4-5), and garcinone F (6) along with twelve known compounds 7-18 were obtained from the latex of Garcinia cowa Roxb. ex Choisy. All new compounds have a 1,3,7-trioxygenated or 1,3,6,7-tetraoxygenated xanthone nucleus and differ from majority of xanthones from G. cowa by hydrated side chains. Compounds 1, 7, 8 and 18 exhibited significant neuroprotective effects on glutamate-mediated hippocampal neuronal HT22 cell death. In particular, compound 1 exhibited the most potent neuroprotective effect with > 80 % cell viability in the concentration range of 2.9 -115 μM. Further studies on compound 1 showed that it decreased cellular Ca 2 + influx and inhibits cellular reactive oxygen species generation in HT22 cells. A Western blot analysis showed that MAPK phosphorylation, Bax, and AIF translocation dramatically increased upon treatment with 5 mM glutamate and decreased upon a co-treatment with compound 1.

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Natural Xanthone α‐Mangostin Inhibits LPS‐Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF‐κB Signaling Pathway

Guan

Tan

et al. 2020

Molecular Nutrition Food Res

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ScopeThe effect of α‐mangostin (α‐M), a polyphenolic xanthone isolated from mangostin, on lipopolysaccharide (LPS)‐induced microglial activation and memory impairment is explored. The possible underlying mechanisms are also investigated.Methods and ResultsCytokine production and activation of transforming growth factor activated kinase‐1 (TAK1) and nuclear factor‐κB (NF‐κB) are detected by enzyme‐linked immunosorbent assay (ELISA) or Western blot. Microglial migration and phagocytosis are evaluated with scratch wound‐healing assay and phagocytosis of fluorescent latex beads, respectively. Learning and memory abilities of mice are evaluated with the Morris water maze test. The nanomolar (100–500 nm) α‐M suppresses LPS‐induced pro‐inflammatory cytokine production and inducible nitric oxide synthase (iNOS) expression in microglia. It also inhibits LPS‐induced microglial migration and phagocytosis. α‐M rescues LPS‐caused, microglia‐mediated neuronal dendritic damage. Moreover, α‐M represses LPS‐induced toll‐like receptor 4 (TLR4) expression and activation of TAK1 and NF‐κB. In a mouse neuroinflammation model, α‐M (50 mg kg−1 day−1) shows obvious anti‐neuroinflammatory, neuroprotective, and memory‐improving effects in vivo.Conclusionα‐M inhibits microglia‐mediated neuroinflammation and prevents neurotoxicity and memory impairment from inflammatory damage. These results indicate that α‐M has great potential to be used as a nutritional preventive strategy for neuroinflammation‐related neurodegenerative disorders such as Alzheimer's disease.

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Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice

Cited by 47 publications

References 50 publications

The Pivotal Neuroinflammatory, Therapeutic and Neuroprotective Role of Alpha-Mangostin

The Pivotal Neuroinflammatory, Therapeutic and Neuroprotective Role of Alpha-Mangostin

Six New Polyoxygenated Xanthones from Garcinia cowa and Their Neuroprotective Effects on Glutamate‐Mediated Hippocampal Neuronal HT22 Cell Death

Natural Xanthone α‐Mangostin Inhibits LPS‐Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF‐κB Signaling Pathway

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