Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells

Horiba, Taro; Katsukawa, Masahiro; Abe, Keiko; Nakai, Yuji

doi:10.1080/09168451.2014.940832

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…For that, the anti-oxidant and anti-inflammatory effects of mangosteen could improve the environment surrounding the MSCs and lead to better survival of them. Furthermore, mangosteen could cause enhancement of MSCs differentiation as it was reported by earlier study that α-mangostin promotes myoblast differentiation of C 2 C 12 cells which are murine myoblasts derived from satellite cells [43] .…”

Section: Isoproterenolmentioning

confidence: 85%

Histological and Immunohistochemical Study on the Possible Effect of Mangosteen and Mesenchymal Stem Cells on Isoproterenol Induced Myocardial Infarction in Adult Male Albino Rats

Ismail

Morcos

EL-Shafei

et al. 2019

Egyptian Journal of Histology

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Background: Myocardial infarction (MI) is one of the causes of cardiovascular diseases that lead to death despite of the great advancements in the medical interventions. Aim of the work: To assess the possible effect of mangosteen and mesenchymal stem cells (MSCs) in Isoproterenol (ISO)induced MI in adult male albino rats, monitored by histological and immunohistochemical methods. Materials and Methods: Fifty-five adult male albino rats were divided into: control group (GI), group II (ISO), group III (Mangosteen+ISO), group IV (ISO+MSCs), group V (Mangosteen+Isoproterenol+MSCs). ISO was given subcutaneously, twice (250mg/kg/d), mangosteen was given orally (18mg/200gm) and MSCs (5x10 6 cells in 1mL of PBS) were injected intracardiac. Myocardial sections were stained with H&E, Masson's trichrome and immunohistochemical stain for caspase-3 and vascular endothelial growth factor (VEGF). The mean area % of collagen fibers and immunoreactivity of caspase-3 and VEGF were measured by the image analyzer. The statistical analysis was applied by using ANOVA. Results: Myocardial sections of G II revealed discontinuity and degeneration of cardiac muscle fibers, pyknotic nuclei, inflammatory cellular infiltration and congested blood vessels. There were increased collagen deposition and significant increase in caspase-3 immunoreactivity. Mangosteen administration (G III) showed partial improvement in cardiac muscle fibers and reduced inflammatory cellular infiltration. MSCs treatment (G IV) resulted in obvious decline in myocardial damage, apoptosis with significant reduction of collagen deposition and significant increase in VEGF immunoreactivity. Better results are obtained when MSCs and mangosteen were combined (G V). Conclusion: Mangosteen exerts a synergistic effect with MSCs against ISO-induced MI.

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Section: Isoproterenolmentioning

confidence: 85%

Histological and Immunohistochemical Study on the Possible Effect of Mangosteen and Mesenchymal Stem Cells on Isoproterenol Induced Myocardial Infarction in Adult Male Albino Rats

Ismail

Morcos

EL-Shafei

et al. 2019

Egyptian Journal of Histology

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“…Another study stated that αmangosteen promotes myoblast differentiation by modulating gene expression. Transdifferentiation of myoblasts into osteoblasts allows it to be used for bone therapy [12]. α-mangosteen is the active compound and the most abundant of the xanthone group (75-85%) [13][14].…”

Section: Introductionmentioning

confidence: 99%

The Effect of α-Mangosteen on Runt-Related Transcription Factor 2 and Tartrate-Resistant Acid Phosphatase 5b Expressions on Bone Remodeling in Periodontitis (An Experimental Research on Wistar Rats)

Lestari¹,

Darwin²,

Putra³

et al. 2022

Advances in Health Sciences Research

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The alteration of supporting structures of the teeth in periodontitis results from the complex interaction between colonies of microorganisms and the immune-inflammatory host response. α-mangosteen contains xanthone which has antioxidant, anti-inflammatory, anti-fungal, and osteoinductive properties and has the potential as an alternative treatment to promote bone remodeling of the damaged bone in periodontitis. This study aims to investigate the effect of α-mangosteen on RUNX2, and TRAP5b. Forty-eight Wistar rats aged 2-3 months with bodyweight 250-300 g were used in this study. Rats were divided randomly into 8 groups (4 groups in 2-day-periods). Group 1 as the negative control, group 2,3, and 4 were given αmangosteen hydrogel with the concentration of 0.5%, 1%, and 2% respectively. The alveolar bone on the left mandible of the rats was removed by using low-speed inverted bur with the size of 3mm in the mesiodistal direction, 2mm in the crown-root direction, and 1mm at the buccolingual direction. The α-mangosteen was applied after on the site of the removed bone in the subject groups. At the end of each treatment period (day 7 and day 14), the examination of RUNX2 and TRAP5b expression with immunohistochemical analysis was done. The results of this study showed that on day 7 and day 14, α-mangosteen had an effect on RUNX2. Meanwhile, the TRAP5b examination showed that there was an effect of α-mangosteen on day 7, but not on day 14. αmangosteen as an antioxidant has a role in bone healing. RUNX2 plays an essential role in osteoblast differentiation, while TRAP5b was found necessary for osteoclast differentiation. The conclusion of this study shows that αmangosteen affect RUNX2 and TRAP5b.

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Alpha-mangostin attenuates the apoptotic pathway of abamectin in the fetal rats’ brain by targeting pro-oxidant stimulus, catecholaminergic neurotransmitters, and transcriptional regulation of reelin and nestin

Ibrahim

Eleyan

Khwanes

et al. 2021

Drug and Chemical Toxicology

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Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells

Cited by 5 publications

References 34 publications

Histological and Immunohistochemical Study on the Possible Effect of Mangosteen and Mesenchymal Stem Cells on Isoproterenol Induced Myocardial Infarction in Adult Male Albino Rats

Histological and Immunohistochemical Study on the Possible Effect of Mangosteen and Mesenchymal Stem Cells on Isoproterenol Induced Myocardial Infarction in Adult Male Albino Rats

The Effect of α-Mangosteen on Runt-Related Transcription Factor 2 and Tartrate-Resistant Acid Phosphatase 5b Expressions on Bone Remodeling in Periodontitis (An Experimental Research on Wistar Rats)

Alpha-mangostin attenuates the apoptotic pathway of abamectin in the fetal rats’ brain by targeting pro-oxidant stimulus, catecholaminergic neurotransmitters, and transcriptional regulation of reelin and nestin

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