Alpha power oscillation in the frontal cortex under Bromazepam and Modafinil effects

Abstract

Objective Our aim was to investigate and compare the neuromodulatory effects of bromazepam (6 mg) and modafinil (200 mg) during a sensorimotor task analyzing the changes produced in the absolute alpha power.Method The sample was composed of 15 healthy individuals exposed to three experimental conditions: placebo, modafinil and bromazepam. EEG data were recorded before, during and after the execution of the task. A three-way ANOVA was applied, in order to compare the absolute alpha power among the factors: Group (control, bromazepam and modafinil) Condition (Pre and Post-drug ingestion) and Moment (pre and post-stimulus).Results Interaction was found between the group and condition factors for Fp1, F4 and F3. We observed a main effect of moment and condition for the Fp2, F8 and Fz electrodes.Conclusion We concluded that drugs may interfere in sensorimotor processes, such as in the performance of tasks carried out in an unpredictable scenario.

Investigating the Effect of Intrinsic Motivation on Alpha Desynchronization Using Sample Entropy

“…The result suggested that when participants are unmotivated, the complexity of the data between two recognition cases is similar. The areas where we can observe the difference the most are the frontal and around the left PPA areas, which are also consistent with the findings in previous research [ 18 , 23 , 24 , 25 , 26 , 27 ]. These findings allowed us to grasp the global characteristic differences of alpha desynchronization patterns under intrinsic motivation and the locations to place electrodes for detection.…”

“…The affected channels also coincided with the conventional channels related to the attention task. The frontal area is one of the conventional areas used in EEG cognitive research, which was found to be related to the attention and cognitive performance of subjects [ 23 , 24 ]. The cognitive task with scenery stimulus was also found to cause the activation of the parahippocampal place area (PPA) in the temporal area in fMRI research [ 25 , 26 , 27 ].…”

Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography

“…In this sense, bromazepam affects perception due to the changes in inputs and neural outputs related to the learning process and muscle relaxation during the execution of visuomotor tasks (Montenegro et al, 2005;Cunha et al, 2006;Machado et al, 2009;Gongora et al, 2014;Aprigio et al, 2015). These effects could be due to increasing the reaction time during the execution of tasks; could induce greater attention level or reduce the mental effort in the performance of motor tasks (Cunha et al, 2008).…”