Pathology, Prevention and Therapeutics of Neurodegenerative Disease 2018
DOI: 10.1007/978-981-13-0944-1_1
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Alpha Synuclein and Parkinson’s Disease

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Cited by 7 publications
(6 citation statements)
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“…In recent days, there has been a growing interest in exploring the contribution of neurodegenerative pathways in epilepsy, focusing in particular on α-synuclein, Aβ, and tau. α-synuclein has been widely explored in PD and other synucleinopathies [118][119][120], where its aggregation impairs neuronal, synaptic, and mitochondrial functions along with protein degradation pathways, ensuring its role in PD pathogenesis [121]. In addition, Aβ and tau have been implicated in neurodegenerative disorders, mainly AD, where the accumulation of Aβ initiates an insult that ultimately drives the accretion of tau pathology and tau-mediated neurodegeneration [122].…”
Section: Discussionmentioning
confidence: 99%
“…In recent days, there has been a growing interest in exploring the contribution of neurodegenerative pathways in epilepsy, focusing in particular on α-synuclein, Aβ, and tau. α-synuclein has been widely explored in PD and other synucleinopathies [118][119][120], where its aggregation impairs neuronal, synaptic, and mitochondrial functions along with protein degradation pathways, ensuring its role in PD pathogenesis [121]. In addition, Aβ and tau have been implicated in neurodegenerative disorders, mainly AD, where the accumulation of Aβ initiates an insult that ultimately drives the accretion of tau pathology and tau-mediated neurodegeneration [122].…”
Section: Discussionmentioning
confidence: 99%
“…Extensive research has focused on the regulatory role of αSyn on synaptic function, with knockout studies in Drosophila targeting the αSyn protein-encoding gene, SNCA, highlighting its role in vesicular trafficking, docking, and subsequent neurotransmitter release [ 75 , 76 ]. Although believed to maintain homeostatic function under normal expression [ 77 ], αSyn is most often referred to in association with the pathology of neurodegenerative disorders under the umbrella term “synucleinopathies”, including PD and multiple system atrophy (MSA) [ 78 , 79 , 80 , 81 , 82 ]. Furthermore, aggregations of insoluble αSyn deposits are highly associated with idiopathic PD and are unequivocally the key contributors to the formation of Lewy bodies and Lewy neurites, the hallmark inclusions in PD and in other synucleinopathies such as Lewy body dementia (LBD) [ 83 , 84 ].…”
Section: Alpha-synucleinmentioning
confidence: 99%
“…There are around seven Sirtuins (1−7), and they have different locations inside the cell. SIRT (1,6,7) are located in nucleus, SIRT (3,4,5) are found in mitochondria, whereas SIRT2 is present in cytoplasmic fraction. 61 A study reported that SIRT1 is able to ameliorate α-synuclein induced toxicity.…”
Section: C-terminus Of Hsc70-interacting Protein (Chip)mentioning
confidence: 98%
“…α-Synuclein pathology is the most focused area in PD research. It is believed that PD initiates due to misfolding of α-synuclein. , Braak’s hypothesis states that sporadic PD pathology advances in different stages. It originates in olfactory bulb and GIT and then slowly progresses toward brain .…”
Section: Introductionmentioning
confidence: 99%