Alpha-synuclein mutations in Parkinson Disease in the Kazakh population.

Akanova, Assiya; Kondybayeva, Aida; Kamenova, Saltanat; Chirkin, Alexander; Skiba, Yrii

doi:10.1016/j.parkreldis.2015.10.605

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No PD prevalence data are available from the remaining countries of the concerned regions. Referencing the doctoral thesis of Akanova [6] and her thesis-related conference abstract in English [12, 13] displays some figures concerning the incidence and prevalence of PD in Kazakhstan. Thus, according to her research in 2013, there were 7,628 PD patients registered with the database of the state health statistics, which is based on the International Classification of Diseases, Tenth Revision (ICD-10).…”

Section: Resultsmentioning

confidence: 99%

Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care

Kaiyrzhanov

Aitkulova

Zharkinbekova

et al. 2019

Parkinson's Disease

View full text Add to dashboard Cite

Our understanding of Parkinson’s disease (PD) has significantly accelerated over the last few years, but predominant advances have been made in developed, Western countries. Little is known about PD in the Central Asian (CA) and Transcaucasian (TC) countries. Here, we review the clinical characteristics, treatments used, epidemiology, and genetics of PD in CA and TC countries via a methodological search in MEDLINE, EMBASE, Scopus, Web of Science, and Google Scholar databases. For the acquisition of PD care-related data, the search was extended to the local web resources. Our findings showed that PD prevalence in the region is averaging 62 per 100,000 population. The mean age of onset is 56.4 ± 2.8 in females and 63.3 ± 3.5 in males. Large-scale national studies on PD prevalence from the region are currently lacking. A limited number of genetic studies with small cohorts and inconclusive results were identified. The G2019S LRRK2 mutation, the commonest mutation in PD worldwide, was found in 5.7% of patients with idiopathic PD and 17.6% of familial cases in 153 Uzbek patients. Our review highlighted systematic deficiencies in PD health care in the region including lacks of neurologists specializing in PD, delays in PD diagnosis, absence of specialized PD nurses and PD rehab services, limited access to PD medications and surgery, and the unavailability of PD infusion therapies. Overall, this article demonstrated the paucity of data on this common neurological disorder in CA and TC countries and identified a number of healthcare areas that require an urgent consideration. We conclude that well-designed large-scale epidemiological, genetic, and clinical studies are desperately needed in this region. Healthcare professionals, local and national institutions, and stakeholders must come together to address deficiencies in PD healthcare systems in CA and TC countries.

show abstract

Section: Resultsmentioning

confidence: 99%

Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care

Kaiyrzhanov

Aitkulova

Zharkinbekova

et al. 2019

Parkinson's Disease

View full text Add to dashboard Cite

show abstract

“…The prevalence of PD patients in Kazakhstan averages 62 cases per 100,000 and increases significantly above 70 years of age, with the average age of onset being 56.4 ±2.8 for women and 63.3 ±3.5 for men [5,6]. Various studies have shown that the disease manifests when 50% to 70% of substantia nigra neurons die and dopamine levels in the striatum are reduced by more than 80% [7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Synopsis

Kamenova

Aralbayeva

Iskakova

et al. 2021

IAM

View full text Add to dashboard Cite

We observed 106 Parkinson's patients in Almaty city to detect non-motor visual disorders. Among non-motor symptoms in patients with Parkinson's disease (PD), visual symptoms are becoming increasingly important. Visual impairments cause severe disability, reduce compensatory ability and adaptation of the patient to motor impairments and reduce life expectancy. Many neurologists do not take into serious consideration the importance of visual disorders in PD. This type of research has never been carried out in Kazakhstan or indeed the rest of Central Asia.To study visual non-motor disorders in PD patients in Almaty to help optimize diagnosis and evaluate their correlation with disease duration and severity.The diagnosis included the following elements: patient's complaints and history, a general physical examination, a neurological examination with auxiliary assessment scales.The study confirmed that non-motor manifestations are common in PD patients. Research to date has confirmed the predictive value of non-motor PD manifestations.Non-motor visual impairments are important to the overall quality of life of Parkinson's patients as well its motor manifestation, and require a very careful approach and considerable effort for early detection by a physician, medical personnel and caregivers, including relatives.

show abstract

Alpha-synuclein mutations in Parkinson Disease in the Kazakh population.

Cited by 2 publications

References 0 publications

Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care

Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care

Synopsis

Contact Info

Product

Resources

About