Vaccines for Biodefense and Emerging and Neglected Diseases 2009
DOI: 10.1016/b978-0-12-369408-9.00021-4
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Alphaviral Encephalitides

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Cited by 11 publications
(10 citation statements)
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References 161 publications
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“…Although a variety of vaccines has been developed for EEE, including one used to protect laboratory workers under an IND permit [17], none has been tested for its ability to protect against aerosol challenge of primates. The chimeric SINV-based EEEV vaccines described here were previously shown protect mice from peripheral challenge [17], and here we describe their ability to protect NHPs from a lethal aerosol challenge.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although a variety of vaccines has been developed for EEE, including one used to protect laboratory workers under an IND permit [17], none has been tested for its ability to protect against aerosol challenge of primates. The chimeric SINV-based EEEV vaccines described here were previously shown protect mice from peripheral challenge [17], and here we describe their ability to protect NHPs from a lethal aerosol challenge.…”
Section: Discussionmentioning
confidence: 99%
“…The chimeric SINV-based EEEV vaccines described here were previously shown protect mice from peripheral challenge [17], and here we describe their ability to protect NHPs from a lethal aerosol challenge. Eighty-two percent of animals challenged 45 or 66 days after a single vaccination survived, generally with strong neutralizing Ab responses and nearly complete protection against several physiological measures of disease.…”
Section: Discussionmentioning
confidence: 99%
“…Alphaviruses, Venezuelan equine encephalitis virus (VEEV), Eastern equine encephalitis virus (EEEV), and WEEV are grouped geographically as New World viruses capable of causing disease in both equids and humans, exhibiting overt encephalitic features in a significant number of cases. WEEV causes periodic epizootic outbreaks in Western and Central North America and is maintained in an enzootic cycle between mosquitos and birds or rodents [ 1 ] Humans are usually infected as a result of close proximity to infected equines and by being bitten by an infected mosquito. In humans, WEEV infections are generally asymptomatic but may result in the onset of flu-like symptoms; fever, malaise, headaches, vomiting, and nausea.…”
Section: Introductionmentioning
confidence: 99%
“…Despite the fact that veterinary vaccines are widely available [ 28 ], there are currently no vaccines against EEEV, VEEV, or WEEV licensed for human use. Early research on vaccines against equine encephalitis viruses focused on the development of inactivated viruses through common methods such as heat or formalin [ 29 ].…”
Section: Introductionmentioning
confidence: 99%