2020
DOI: 10.1007/s10753-020-01248-3
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Alpinetin Protects Chondrocytes and Exhibits Anti-Inflammatory Effects via the NF-κB/ERK Pathway for Alleviating Osteoarthritis

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Cited by 28 publications
(16 citation statements)
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“…38 Furthermore, blocking inflammatory factors attenuates cartilage degeneration during OA. 39,40 Therefore, non-steroidal anti-inflammatory drugs (NSAIDs) However, long-term use of NSAIDs could be associated with multiple complications, including acute renal impairment and dyspepsia. 41 Thus, an effective therapy is urgently needed as an alternative to take the place of NSAIDs in curing OA.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…38 Furthermore, blocking inflammatory factors attenuates cartilage degeneration during OA. 39,40 Therefore, non-steroidal anti-inflammatory drugs (NSAIDs) However, long-term use of NSAIDs could be associated with multiple complications, including acute renal impairment and dyspepsia. 41 Thus, an effective therapy is urgently needed as an alternative to take the place of NSAIDs in curing OA.…”
Section: Discussionmentioning
confidence: 99%
“… 38 Furthermore, blocking inflammatory factors attenuates cartilage degeneration during OA. 39 , 40 Therefore, non‐steroidal anti‐inflammatory drugs (NSAIDs) are the most common used clinical prescriptions to alleviate OA pain. However, long‐term use of NSAIDs could be associated with multiple complications, including acute renal impairment and dyspepsia.…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that morroniside protects against ECM degradation and OA development by decreasing the expression of MMP-3/-13 in the destabilization of the medial meniscus-induced mouse OA models ( Park et al, 2021 ). Alpinetin, a natural flavonoid compound, can effectively reduce TNFα-induced MMP-13 and ADAMTS-5 expression and protect against cartilage destruction in rat OA chondrocytes ( Gao et al, 2020 ). XH has been shown various biological activities, including anti-inflammation, anti-oxidation, anti-proliferation, and anti-angiogenesis ( Harikumar et al, 2009 ; Krajka-Kuźniak et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…The most significantly enriched terms were ‘scavenger receptor activity’ and ‘TNF signaling’. TNF-α is a member of TNF signaling and is able to activate NF-κB signaling to induce cartilage damage ( 29 ). Ren et al ( 30 ) performed a bioinformatics analysis that focused on the DEGs in knee OA in a rat model.…”
Section: Discussionmentioning
confidence: 99%