ALSUntangled #61: melatonin

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doi:10.1080/21678421.2021.1927103

Cited by 1 publication

(1 citation statement)

References 20 publications

(38 reference statements)

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“…Circulating serum protein carbonyls (a marker of protein oxidation) were elevated in ALS patients, but were normalized to control values by melatonin treatment [79]. Moreover, two ALS cases, in which cocktails of supplements including melatonin were associated with a partial recovery of lost motor function, support further studies with melatonin, at least in a pilot trial [80].…”

Section: Antioxidantsmentioning

confidence: 82%

NAD+ Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis

et al. 2021

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Charcot first described amyotrophic lateral sclerosis (ALS) between 1865 and 1874 as a sporadic adult disease resulting from the idiopathic progressive degeneration of the motor neuronal system, resulting in rapid, progressive, and generalized muscle weakness and atrophy. There is no cure for ALS and no proven therapy to prevent it or reverse its course. There are two drugs specifically approved for the treatment of ALS, riluzol and edaravone, and many others have already been tested or are following clinical trials. However, at the present moment, we still cannot glimpse a true breakthrough in the treatment of this devastating disease. Nevertheless, our understanding of the pathophysiology of ALS is constantly growing. Based on this background, we know that oxidative stress, alterations in the NAD+-dependent metabolism and redox status, and abnormal mitochondrial dynamics and function in the motor neurons are at the core of the problem. Thus, different antioxidant molecules or NAD+ generators have been proposed for the therapy of ALS. This review analyzes these options not only in light of their use as individual molecules, but with special emphasis on their potential association, and even as part of broader combined multi-therapies.

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Section: Antioxidantsmentioning

confidence: 82%